Abstract

An easy and accurate assessment of the renal function is a critical requirement for detecting the initial functional decline of the kidney induced by acute or chronic renal disease. A method for measuring the glomerular filtration rate is developed with the accuracy of clearance techniques and the convenience of plasma creatinine. The renal function is measured in rats as the rate of clearance determined from time-resolved transcutaneous fluorescence measurements of a new fluorescent glomerular filtration agent. The agent has a large dose-safety coefficient and the same space distribution and clearance characteristics as iothalamate. This new approach is a convenient and accurate way to perform real-time measurements of the glomerular filtration rate to detect early kidney disease before the renal function becomes severely and irreversibly compromised.

© 2005 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Reagent- and separation-free measurements of urine creatinine concentration using stamping surface enhanced Raman scattering (S-SERS)

Ming Li, Yong Du, Fusheng Zhao, Jianbo Zeng, Chandra Mohan, and Wei-Chuan Shih
Biomed. Opt. Express 6(3) 849-858 (2015)

Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging

Rick Bezemer, Matthieu Legrand, Eva Klijn, Michal Heger, Ivo C. J. H. Post, Thomas M. van Gulik, Didier Payen, and Can Ince
Opt. Express 18(14) 15054-15061 (2010)

Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach

Dirk Grosenick, Kathleen Cantow, Karen Arakelyan, Heidrun Wabnitz, Bert Flemming, Angela Skalweit, Mechthild Ladwig, Rainer Macdonald, Thoralf Niendorf, and Erdmann Seeliger
Biomed. Opt. Express 6(2) 309-323 (2015)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (7)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription