A Monte Carlo technique has been developed to simulate the transillumination laser computed tomography of tissue-engineered blood vessels. The blood vessel was modeled as a single cylinder layer mounted on a tubular mandrel. Sequences of images were acquired while rotating the mandrel. The tomographic image was reconstructed by applying a standard Radon transform. Angular discrimination was applied to simulate a spatial filter, which was used to reject multiply scattered photons. The simulation results indicated that the scattering effect can be overcome with angular discrimination because of the thin tissue thickness. However, any refractive-index mismatch among the tissue, the surrounding media, and the mandrel could produce significant distortions in the reconstructed image.
© 2005 Optical Society of AmericaFull Article | PDF Article
Alwin Kienle, Lothar Lilge, I. Alex Vitkin, Michael S. Patterson, Brian C. Wilson, Raimund Hibst, and Rudolf Steiner
Appl. Opt. 35(7) 1151-1160 (1996)
Pavel Starukhin, Sergey Ulyanov, Ekaterina Galanzha, and Valery Tuchin
Appl. Opt. 39(16) 2823-2830 (2000)
Jennifer Kehlet Barton, T. Joshua Pfefer, Ashley J. Welch, Derek J. Smithies, J. Stuart Nelson, and Martin J.C. van Gemert
Opt. Express 2(9) 391-396 (1998)