Abstract

We show that digital holography can be combined easily with optical coherence tomography approach. Varying the reference path length is the means used to acquire a series of holograms at different depths, providing after reconstruction images of slices at different depths in the specimen thanks to the short-coherence length of light source. A metallic object, covered by a 150-μm-thick onion cell, is imaged with high resolution. Applications in ophthalmology are shown: structures of the anterior eye, the cornea, and the iris, are studied on enucleated porcine eyes. Tomographic images of the iris border close to the pupil were obtained 165 μm underneath the eye surface.

© 2005 Optical Society of America

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
    [CrossRef] [PubMed]
  2. A. F. Fercher, “Optical coherence tomography,” J. Biomed. 1, 157–173 (1996).
  3. W. Drexler, “Ultrahigh resolution optical coherence tomography,” J. Biomed. Opt. 9, 47–74 (2004).
    [CrossRef] [PubMed]
  4. A. G. Podoleanu, J. A. Rogers, D. A. Jackson, “OCT en-face images from the retina with adjustable depth resolution in real time,” IEEE J. Sel. Topics Quantum Electron. 5, 1176–1184 (1999).
    [CrossRef]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  10. M. Tziraki, R. Jones, P. M. W. French, D. D. Nolte, M. R. Melloch, “Short-coherence photorefractive holography in multiple-quantum-well devices using light-emitting diodes,” Appl. Phys. Lett. 75, 1363–1365 (1999).
    [CrossRef]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef]
  19. O. Camber, C. Rehbinder, T. Nikkila, P. Edman, “Morphology of the pig cornea in normal conditions and after incubation in a perfusion apparatus,” Acta Vet. Scand. 28, 127–134 (1987).
    [PubMed]
  20. K. Ludwig, E. Wegscheider, J. P. Hoops, A. Kampik, “In vivo imaging of the human zonular apparatus with high-resolution ultrasound biomicroscopy,” Arch. Ophtalmol. 237, 361–371 (1999).
  21. C. J. Pavlin, F. S. Foster, “High resolution ultrasound,” in Cornea, J. H. Krachmer, M. J. Mannis, E. J. Holland, eds. (Mosby, St. Louis, 1996), Chap. 21.

2004 (2)

2002 (3)

2001 (1)

G. Pedrini, S. Schedin, “Short coherence digital holography for 3D microscopy,” Optik 112, 427–432 (2001).
[CrossRef]

2000 (4)

1999 (5)

E. Cuche, F. Bevilacqua, C. Depeursinge, “Digital holography for quantitative phase-contrast imaging,” Opt. Lett. 24, 291–293 (1999).
[CrossRef]

E. Cuche, P. Marquet, C. Depeursinge, “Simultaneous amplitude-contrast and quantitative phase-contrast microscopy by numerical reconstruction of Fresnel off-axis holograms,” Appl. Opt. 38, 6994–7001 (1999).
[CrossRef]

K. Ludwig, E. Wegscheider, J. P. Hoops, A. Kampik, “In vivo imaging of the human zonular apparatus with high-resolution ultrasound biomicroscopy,” Arch. Ophtalmol. 237, 361–371 (1999).

A. G. Podoleanu, J. A. Rogers, D. A. Jackson, “OCT en-face images from the retina with adjustable depth resolution in real time,” IEEE J. Sel. Topics Quantum Electron. 5, 1176–1184 (1999).
[CrossRef]

M. Tziraki, R. Jones, P. M. W. French, D. D. Nolte, M. R. Melloch, “Short-coherence photorefractive holography in multiple-quantum-well devices using light-emitting diodes,” Appl. Phys. Lett. 75, 1363–1365 (1999).
[CrossRef]

1997 (1)

E. Cuche, P. Poscio, C. Depeursinge, “Optical tomography by means of a numerical low-coherence holographic technique,” Journal of Optics-Nouvelle Revue D’Optique 28, 260–264 (1997).

1996 (1)

A. F. Fercher, “Optical coherence tomography,” J. Biomed. 1, 157–173 (1996).

1995 (1)

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

1987 (1)

O. Camber, C. Rehbinder, T. Nikkila, P. Edman, “Morphology of the pig cornea in normal conditions and after incubation in a perfusion apparatus,” Acta Vet. Scand. 28, 127–134 (1987).
[PubMed]

Barry, N. P.

Beaurepaire, E.

Bevilacqua, F.

Boccara, A. C.

Boccara, C.

Bourquin, S.

Camber, O.

O. Camber, C. Rehbinder, T. Nikkila, P. Edman, “Morphology of the pig cornea in normal conditions and after incubation in a perfusion apparatus,” Acta Vet. Scand. 28, 127–134 (1987).
[PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Cuche, E.

Dainty, J. C.

Depeursinge, C.

Drexler, W.

W. Drexler, “Ultrahigh resolution optical coherence tomography,” J. Biomed. Opt. 9, 47–74 (2004).
[CrossRef] [PubMed]

Dubois, A.

Edman, P.

O. Camber, C. Rehbinder, T. Nikkila, P. Edman, “Morphology of the pig cornea in normal conditions and after incubation in a perfusion apparatus,” Acta Vet. Scand. 28, 127–134 (1987).
[PubMed]

Fercher, A. F.

A. F. Fercher, “Optical coherence tomography,” J. Biomed. 1, 157–173 (1996).

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Foster, F. S.

C. J. Pavlin, F. S. Foster, “High resolution ultrasound,” in Cornea, J. H. Krachmer, M. J. Mannis, E. J. Holland, eds. (Mosby, St. Louis, 1996), Chap. 21.

French, P. M. W.

M. Tziraki, R. Jones, P. M. W. French, D. D. Nolte, M. R. Melloch, “Short-coherence photorefractive holography in multiple-quantum-well devices using light-emitting diodes,” Appl. Phys. Lett. 75, 1363–1365 (1999).
[CrossRef]

S. C. W. Hyde, N. P. Barry, R. Jones, J. C. Dainty, P. M. W. French, M. B. Klein, B. A. Wechsler, “Depth-resolved holographic imaging through scattering media by photorefraction,” Opt. Lett. 20, 1331–1333 (1995).
[CrossRef] [PubMed]

Fujimoto, J. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Grieve, K.

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Hoops, J. P.

K. Ludwig, E. Wegscheider, J. P. Hoops, A. Kampik, “In vivo imaging of the human zonular apparatus with high-resolution ultrasound biomicroscopy,” Arch. Ophtalmol. 237, 361–371 (1999).

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Hyde, S. C. W.

Indebetouw, G.

Jackson, D. A.

A. G. Podoleanu, J. A. Rogers, D. A. Jackson, “OCT en-face images from the retina with adjustable depth resolution in real time,” IEEE J. Sel. Topics Quantum Electron. 5, 1176–1184 (1999).
[CrossRef]

Jones, R.

M. Tziraki, R. Jones, P. M. W. French, D. D. Nolte, M. R. Melloch, “Short-coherence photorefractive holography in multiple-quantum-well devices using light-emitting diodes,” Appl. Phys. Lett. 75, 1363–1365 (1999).
[CrossRef]

S. C. W. Hyde, N. P. Barry, R. Jones, J. C. Dainty, P. M. W. French, M. B. Klein, B. A. Wechsler, “Depth-resolved holographic imaging through scattering media by photorefraction,” Opt. Lett. 20, 1331–1333 (1995).
[CrossRef] [PubMed]

Kampik, A.

K. Ludwig, E. Wegscheider, J. P. Hoops, A. Kampik, “In vivo imaging of the human zonular apparatus with high-resolution ultrasound biomicroscopy,” Arch. Ophtalmol. 237, 361–371 (1999).

Klein, M. B.

Klysubun, P.

Lecaque, R.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Ludwig, K.

K. Ludwig, E. Wegscheider, J. P. Hoops, A. Kampik, “In vivo imaging of the human zonular apparatus with high-resolution ultrasound biomicroscopy,” Arch. Ophtalmol. 237, 361–371 (1999).

Marquet, P.

Melloch, M. R.

M. Tziraki, R. Jones, P. M. W. French, D. D. Nolte, M. R. Melloch, “Short-coherence photorefractive holography in multiple-quantum-well devices using light-emitting diodes,” Appl. Phys. Lett. 75, 1363–1365 (1999).
[CrossRef]

Moneron, G.

Monterosso, V.

Nikkila, T.

O. Camber, C. Rehbinder, T. Nikkila, P. Edman, “Morphology of the pig cornea in normal conditions and after incubation in a perfusion apparatus,” Acta Vet. Scand. 28, 127–134 (1987).
[PubMed]

Nolte, D. D.

M. Tziraki, R. Jones, P. M. W. French, D. D. Nolte, M. R. Melloch, “Short-coherence photorefractive holography in multiple-quantum-well devices using light-emitting diodes,” Appl. Phys. Lett. 75, 1363–1365 (1999).
[CrossRef]

Pavlin, C. J.

C. J. Pavlin, F. S. Foster, “High resolution ultrasound,” in Cornea, J. H. Krachmer, M. J. Mannis, E. J. Holland, eds. (Mosby, St. Louis, 1996), Chap. 21.

Pedrini, G.

Podoleanu, A. G.

A. G. Podoleanu, J. A. Rogers, D. A. Jackson, “OCT en-face images from the retina with adjustable depth resolution in real time,” IEEE J. Sel. Topics Quantum Electron. 5, 1176–1184 (1999).
[CrossRef]

Poscio, P.

E. Cuche, P. Poscio, C. Depeursinge, “Optical tomography by means of a numerical low-coherence holographic technique,” Journal of Optics-Nouvelle Revue D’Optique 28, 260–264 (1997).

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Rehbinder, C.

O. Camber, C. Rehbinder, T. Nikkila, P. Edman, “Morphology of the pig cornea in normal conditions and after incubation in a perfusion apparatus,” Acta Vet. Scand. 28, 127–134 (1987).
[PubMed]

Rogers, J. A.

A. G. Podoleanu, J. A. Rogers, D. A. Jackson, “OCT en-face images from the retina with adjustable depth resolution in real time,” IEEE J. Sel. Topics Quantum Electron. 5, 1176–1184 (1999).
[CrossRef]

Salathe, R. P.

Schedin, S.

G. Pedrini, S. Schedin, “Short coherence digital holography for 3D microscopy,” Optik 112, 427–432 (2001).
[CrossRef]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Seitz, P.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Tiziani, H. J.

Tziraki, M.

M. Tziraki, R. Jones, P. M. W. French, D. D. Nolte, M. R. Melloch, “Short-coherence photorefractive holography in multiple-quantum-well devices using light-emitting diodes,” Appl. Phys. Lett. 75, 1363–1365 (1999).
[CrossRef]

Vabre, L.

Wechsler, B. A.

Wegscheider, E.

K. Ludwig, E. Wegscheider, J. P. Hoops, A. Kampik, “In vivo imaging of the human zonular apparatus with high-resolution ultrasound biomicroscopy,” Arch. Ophtalmol. 237, 361–371 (1999).

Acta Vet. Scand. (1)

O. Camber, C. Rehbinder, T. Nikkila, P. Edman, “Morphology of the pig cornea in normal conditions and after incubation in a perfusion apparatus,” Acta Vet. Scand. 28, 127–134 (1987).
[PubMed]

Appl. Opt. (5)

Appl. Phys. Lett. (1)

M. Tziraki, R. Jones, P. M. W. French, D. D. Nolte, M. R. Melloch, “Short-coherence photorefractive holography in multiple-quantum-well devices using light-emitting diodes,” Appl. Phys. Lett. 75, 1363–1365 (1999).
[CrossRef]

Arch. Ophtalmol. (1)

K. Ludwig, E. Wegscheider, J. P. Hoops, A. Kampik, “In vivo imaging of the human zonular apparatus with high-resolution ultrasound biomicroscopy,” Arch. Ophtalmol. 237, 361–371 (1999).

IEEE J. Sel. Topics Quantum Electron. (1)

A. G. Podoleanu, J. A. Rogers, D. A. Jackson, “OCT en-face images from the retina with adjustable depth resolution in real time,” IEEE J. Sel. Topics Quantum Electron. 5, 1176–1184 (1999).
[CrossRef]

J. Biomed. (1)

A. F. Fercher, “Optical coherence tomography,” J. Biomed. 1, 157–173 (1996).

J. Biomed. Opt. (1)

W. Drexler, “Ultrahigh resolution optical coherence tomography,” J. Biomed. Opt. 9, 47–74 (2004).
[CrossRef] [PubMed]

Journal of Optics-Nouvelle Revue D’Optique (1)

E. Cuche, P. Poscio, C. Depeursinge, “Optical tomography by means of a numerical low-coherence holographic technique,” Journal of Optics-Nouvelle Revue D’Optique 28, 260–264 (1997).

Opt. Commun. (1)

E. Cuche, P. Marquet, C. Depeursinge, “Aperture apodization using cubic spline interpolation: application in digital holographic microscopy,” Opt. Commun. 182, 59–69 (2000).
[CrossRef]

Opt. Lett. (5)

Optik (1)

G. Pedrini, S. Schedin, “Short coherence digital holography for 3D microscopy,” Optik 112, 427–432 (2001).
[CrossRef]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Other (1)

C. J. Pavlin, F. S. Foster, “High resolution ultrasound,” in Cornea, J. H. Krachmer, M. J. Mannis, E. J. Holland, eds. (Mosby, St. Louis, 1996), Chap. 21.

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