Abstract

We introduce a modified Tikhonov regularization method to include three-dimensional x-ray mammography as a prior in the diffuse optical tomography reconstruction. With simulations we show that the optical image reconstruction resolution and contrast are improved by implementing this x-ray-guided spatial constraint. We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method.

© 2003 Optical Society of America

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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  8. S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, D. A. Boas, “Bedside functional imaging of the premature infant brain during passive motor activation,” J. Perinat. Med. 29, 335–343 (2001).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [PubMed]
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    [CrossRef]

2003

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

2002

M. Belge, M. Kilmer, L. E. Miller, “Efficient determination of multiple regularization parameters in a generalized L-curve framework,” Inverse Probl. 18, 1161–1183 (2002).
[CrossRef]

V. Ntziachristos, A. G. Yodh, M. Schnall, B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4, 347–354 (2002).
[CrossRef] [PubMed]

2001

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, D. A. Boas, “Bedside functional imaging of the premature infant brain during passive motor activation,” J. Perinat. Med. 29, 335–343 (2001).
[CrossRef] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18 (6), 57–75 (2001).
[CrossRef]

J. P. Culver, V. Ntziachristos, M. J. Holboke, A. G. Yodh, “Optimization of optode arrangements for diffuse optical tomography: a singular-value analysis,” Opt. Lett. 26, 701–703 (2001).
[CrossRef]

2000

M. A. Franceschini, V. Toronov, M. Filiaci, E. Gratton, S. Fanini, “On-line optical imaging of the human brain with 160-ms temporal resolution,” Opt. Express 6, 49–57 (2000), http://www.opticsexpress.org .
[CrossRef] [PubMed]

R. J. Gaudette, D. H. Brooks, C. A. DiMarzio, M. E. Kilmer, E. L. Miller, T. Gaudette, D. A. Boas, “A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient,” Phys. Med. Biol. 45, 1051–1070 (2000).
[CrossRef] [PubMed]

1999

1998

1997

Y. Hoshi, M. Tamura, “Near-infrared optical detection of sequential brain activation in the prefrontal cortex during mental tasks,” Neuroimage 5, 292–297 (1997).
[CrossRef] [PubMed]

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

1996

A. Maki, Y. Yamashita, E. Watanabe, H. Koizumi, “Visualizing human motor activity by using non-invasive optical topography,” Front. Med. Biol. Eng. 7, 285–297 (1996).
[PubMed]

1995

R. L. Barbour, H. L. Graber, J. Chang, S. S. Barbour, P. C. Koo, R. Aronson, ““MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2(4), 63–77 (1995).
[CrossRef]

A. Yodh, B. Chance, “Spectroscopy and imaging with diffusing light,” Phys. Today 48, 34–40 (1995).
[CrossRef]

S. R. Arridge, “Photo-measurement density functions. Part I: Analytical forms,” Appl. Opt. 34, 7395–7409 (1995).
[CrossRef] [PubMed]

1994

O. Arikan, “Regularized inversion of a two-dimensional integral equation with applications in borehole induction measurements,” Radio Sci. 29, 519–538 (1994).
[CrossRef]

Albagli, D.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Arikan, O.

O. Arikan, “Regularized inversion of a two-dimensional integral equation with applications in borehole induction measurements,” Radio Sci. 29, 519–538 (1994).
[CrossRef]

Aronson, R.

R. L. Barbour, H. L. Graber, J. Chang, S. S. Barbour, P. C. Koo, R. Aronson, ““MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2(4), 63–77 (1995).
[CrossRef]

Arridge, S. R.

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41–R93 (1999).
[CrossRef]

S. R. Arridge, “Photo-measurement density functions. Part I: Analytical forms,” Appl. Opt. 34, 7395–7409 (1995).
[CrossRef] [PubMed]

S. R. Arridge, M. Schweiger, “Inverse methods for optical tomography,” in Proceedings of Information Processing in Medical Imaging (IPMI’93), H. H. Barrett, A. F. Gmitro, eds., Vol. 687 of Lecture Notes in Computer Science, (Springer-Verlag, New York, 1993).

Barbour, R. L.

R. L. Barbour, H. L. Graber, J. Chang, S. S. Barbour, P. C. Koo, R. Aronson, ““MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2(4), 63–77 (1995).
[CrossRef]

Barbour, S. S.

R. L. Barbour, H. L. Graber, J. Chang, S. S. Barbour, P. C. Koo, R. Aronson, ““MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2(4), 63–77 (1995).
[CrossRef]

Belge, M.

M. Belge, M. Kilmer, L. E. Miller, “Efficient determination of multiple regularization parameters in a generalized L-curve framework,” Inverse Probl. 18, 1161–1183 (2002).
[CrossRef]

Benaron, D. A.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, D. A. Boas, “Bedside functional imaging of the premature infant brain during passive motor activation,” J. Perinat. Med. 29, 335–343 (2001).
[CrossRef] [PubMed]

Boas, D. A.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, D. A. Boas, “Bedside functional imaging of the premature infant brain during passive motor activation,” J. Perinat. Med. 29, 335–343 (2001).
[CrossRef] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18 (6), 57–75 (2001).
[CrossRef]

R. J. Gaudette, D. H. Brooks, C. A. DiMarzio, M. E. Kilmer, E. L. Miller, T. Gaudette, D. A. Boas, “A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient,” Phys. Med. Biol. 45, 1051–1070 (2000).
[CrossRef] [PubMed]

D. A. Boas, “Diffuse photon probes of structural and dynamical properties of turbid media: theory and biomedical applications,” Ph.D. dissertation (Department of Physics, University of Pennsylvania, Philadelphia, Pa., 1996).

Q. Zhang, T. J. Brukilacchio, T. Gaudett, L. Wang, A. Li, D. A. Boas, “Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities,” in Optical Tomography and Spectroscopy of Tissue IV, B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, Proc. SPIE4250, 219–238 (2001).

Brooks, D. H.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18 (6), 57–75 (2001).
[CrossRef]

R. J. Gaudette, D. H. Brooks, C. A. DiMarzio, M. E. Kilmer, E. L. Miller, T. Gaudette, D. A. Boas, “A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient,” Phys. Med. Biol. 45, 1051–1070 (2000).
[CrossRef] [PubMed]

Brukilacchio, T. J.

Q. Zhang, T. J. Brukilacchio, T. Gaudett, L. Wang, A. Li, D. A. Boas, “Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities,” in Optical Tomography and Spectroscopy of Tissue IV, B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, Proc. SPIE4250, 219–238 (2001).

Castleberry, D. E.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Chance, B.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

V. Ntziachristos, A. G. Yodh, M. Schnall, B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4, 347–354 (2002).
[CrossRef] [PubMed]

B. Chance, A. Endla, N. Shoko, Z. Shuoming, H. Long, K. Worden, C. Li, T. Murray, Y. Ovetsky, D. Pidikiti, R. Thomas, “A novel method for fast imaging of brain function, non-invasively, with light,” Opt. Express 2, 411–423 (1998), http://www.opticsexpress.org
[CrossRef] [PubMed]

A. Yodh, B. Chance, “Spectroscopy and imaging with diffusing light,” Phys. Today 48, 34–40 (1995).
[CrossRef]

Chang, J.

R. L. Barbour, H. L. Graber, J. Chang, S. S. Barbour, P. C. Koo, R. Aronson, ““MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2(4), 63–77 (1995).
[CrossRef]

Choe, R.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

Christian, B. T.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Culver, J. P.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

J. P. Culver, V. Ntziachristos, M. J. Holboke, A. G. Yodh, “Optimization of optode arrangements for diffuse optical tomography: a singular-value analysis,” Opt. Lett. 26, 701–703 (2001).
[CrossRef]

DeJule, M. C.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

DiMarzio, C. A.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18 (6), 57–75 (2001).
[CrossRef]

R. J. Gaudette, D. H. Brooks, C. A. DiMarzio, M. E. Kilmer, E. L. Miller, T. Gaudette, D. A. Boas, “A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient,” Phys. Med. Biol. 45, 1051–1070 (2000).
[CrossRef] [PubMed]

Durduran, T.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

Q. Zhu, T. Durduran, V. Ntziachristos, M. Holboke, A. G. Yodh, “Imager that combines near-infrared diffusive light and ultrasound,” Opt. Lett. 24, 1050–1052 (1999).
[CrossRef]

Endla, A.

Eppstein, M. J. D.

Fanini, S.

Filiaci, M.

Fitzgerald, P. E.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Fobare, D. F.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Franceschini, M. A.

Gaudett, T.

Q. Zhang, T. J. Brukilacchio, T. Gaudett, L. Wang, A. Li, D. A. Boas, “Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities,” in Optical Tomography and Spectroscopy of Tissue IV, B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, Proc. SPIE4250, 219–238 (2001).

Gaudette, R. J.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18 (6), 57–75 (2001).
[CrossRef]

R. J. Gaudette, D. H. Brooks, C. A. DiMarzio, M. E. Kilmer, E. L. Miller, T. Gaudette, D. A. Boas, “A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient,” Phys. Med. Biol. 45, 1051–1070 (2000).
[CrossRef] [PubMed]

Gaudette, T.

R. J. Gaudette, D. H. Brooks, C. A. DiMarzio, M. E. Kilmer, E. L. Miller, T. Gaudette, D. A. Boas, “A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient,” Phys. Med. Biol. 45, 1051–1070 (2000).
[CrossRef] [PubMed]

Giambattista, B. W.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Giardino, A. A.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Graber, H. L.

R. L. Barbour, H. L. Graber, J. Chang, S. S. Barbour, P. C. Koo, R. Aronson, ““MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2(4), 63–77 (1995).
[CrossRef]

Gratton, E.

Hansen, P. C.

P. C. Hansen, Rank-Deficient and Discrete Ill-Posed Problems: Numerical Aspects of Linear Inversion (SIAM Press, Philadelphia, Pa., 1998).

Hintz, S. R.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, D. A. Boas, “Bedside functional imaging of the premature infant brain during passive motor activation,” J. Perinat. Med. 29, 335–343 (2001).
[CrossRef] [PubMed]

Holboke, M.

Holboke, M. J.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

J. P. Culver, V. Ntziachristos, M. J. Holboke, A. G. Yodh, “Optimization of optode arrangements for diffuse optical tomography: a singular-value analysis,” Opt. Lett. 26, 701–703 (2001).
[CrossRef]

Hoshi, Y.

Y. Hoshi, M. Tamura, “Near-infrared optical detection of sequential brain activation in the prefrontal cortex during mental tasks,” Neuroimage 5, 292–297 (1997).
[CrossRef] [PubMed]

Kilmer, M.

M. Belge, M. Kilmer, L. E. Miller, “Efficient determination of multiple regularization parameters in a generalized L-curve framework,” Inverse Probl. 18, 1161–1183 (2002).
[CrossRef]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18 (6), 57–75 (2001).
[CrossRef]

Kilmer, M. E.

R. J. Gaudette, D. H. Brooks, C. A. DiMarzio, M. E. Kilmer, E. L. Miller, T. Gaudette, D. A. Boas, “A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient,” Phys. Med. Biol. 45, 1051–1070 (2000).
[CrossRef] [PubMed]

Koizumi, H.

A. Maki, Y. Yamashita, E. Watanabe, H. Koizumi, “Visualizing human motor activity by using non-invasive optical topography,” Front. Med. Biol. Eng. 7, 285–297 (1996).
[PubMed]

Koo, P. C.

R. L. Barbour, H. L. Graber, J. Chang, S. S. Barbour, P. C. Koo, R. Aronson, ““MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2(4), 63–77 (1995).
[CrossRef]

Kopans, D. B.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Kwasnick, R. F.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Landberg, C. E.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Li, A.

Q. Zhang, T. J. Brukilacchio, T. Gaudett, L. Wang, A. Li, D. A. Boas, “Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities,” in Optical Tomography and Spectroscopy of Tissue IV, B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, Proc. SPIE4250, 219–238 (2001).

Li, C.

Liu, J.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Long, H.

Lubowski, S. J.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Maki, A.

A. Maki, Y. Yamashita, E. Watanabe, H. Koizumi, “Visualizing human motor activity by using non-invasive optical topography,” Front. Med. Biol. Eng. 7, 285–297 (1996).
[PubMed]

McBride, T. O.

Miller, E. L.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18 (6), 57–75 (2001).
[CrossRef]

R. J. Gaudette, D. H. Brooks, C. A. DiMarzio, M. E. Kilmer, E. L. Miller, T. Gaudette, D. A. Boas, “A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient,” Phys. Med. Biol. 45, 1051–1070 (2000).
[CrossRef] [PubMed]

Miller, L. E.

M. Belge, M. Kilmer, L. E. Miller, “Efficient determination of multiple regularization parameters in a generalized L-curve framework,” Inverse Probl. 18, 1161–1183 (2002).
[CrossRef]

Moore, R.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Murray, T.

Niklason, L. E.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Niklason, L. T.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Ntziachristos, V.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

V. Ntziachristos, A. G. Yodh, M. Schnall, B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4, 347–354 (2002).
[CrossRef] [PubMed]

J. P. Culver, V. Ntziachristos, M. J. Holboke, A. G. Yodh, “Optimization of optode arrangements for diffuse optical tomography: a singular-value analysis,” Opt. Lett. 26, 701–703 (2001).
[CrossRef]

Q. Zhu, T. Durduran, V. Ntziachristos, M. Holboke, A. G. Yodh, “Imager that combines near-infrared diffusive light and ultrasound,” Opt. Lett. 24, 1050–1052 (1999).
[CrossRef]

O’Leary, M. A.

M. A. O’Leary, “Imaging with diffuse photon density waves,” Ph.D. dissertation (Department of Physics, Unversity of Pennsylvania, Philadelphia, Pa., 1996).

Opsahl-Ong, B. H.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Osterberg, U. L.

Ovetsky, Y.

Paulsen, K. D.

Pidikiti, D.

Pogue, B. W.

Possin, G. E.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Prewitt, J.

Richotte, J. F.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Schnall, M.

V. Ntziachristos, A. G. Yodh, M. Schnall, B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4, 347–354 (2002).
[CrossRef] [PubMed]

Schweiger, M.

S. R. Arridge, M. Schweiger, “Inverse methods for optical tomography,” in Proceedings of Information Processing in Medical Imaging (IPMI’93), H. H. Barrett, A. F. Gmitro, eds., Vol. 687 of Lecture Notes in Computer Science, (Springer-Verlag, New York, 1993).

Sevick-Muraca, E. M.

Shoko, N.

Shuoming, Z.

Siegel, A. M.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, D. A. Boas, “Bedside functional imaging of the premature infant brain during passive motor activation,” J. Perinat. Med. 29, 335–343 (2001).
[CrossRef] [PubMed]

Slanetz, P. J.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Slemp, A.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

Stevenson, D. K.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, D. A. Boas, “Bedside functional imaging of the premature infant brain during passive motor activation,” J. Perinat. Med. 29, 335–343 (2001).
[CrossRef] [PubMed]

Tamura, M.

Y. Hoshi, M. Tamura, “Near-infrared optical detection of sequential brain activation in the prefrontal cortex during mental tasks,” Neuroimage 5, 292–297 (1997).
[CrossRef] [PubMed]

Thomas, R.

Toronov, V.

Troy, D. E.

Troy, T. L.

Wang, L.

Q. Zhang, T. J. Brukilacchio, T. Gaudett, L. Wang, A. Li, D. A. Boas, “Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities,” in Optical Tomography and Spectroscopy of Tissue IV, B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, Proc. SPIE4250, 219–238 (2001).

Watanabe, E.

A. Maki, Y. Yamashita, E. Watanabe, H. Koizumi, “Visualizing human motor activity by using non-invasive optical topography,” Front. Med. Biol. Eng. 7, 285–297 (1996).
[PubMed]

Wei, C.-Y.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Wirth, R. F.

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Worden, K.

Wu, T.

T. Wu, “Three dimensional mammography reconstruction using low dose projection images, Ph. D. dissertation (Department of Physics, Brandeis University, Waltham, Mass., 2002).

Yamashita, Y.

A. Maki, Y. Yamashita, E. Watanabe, H. Koizumi, “Visualizing human motor activity by using non-invasive optical topography,” Front. Med. Biol. Eng. 7, 285–297 (1996).
[PubMed]

Yodh, A.

A. Yodh, B. Chance, “Spectroscopy and imaging with diffusing light,” Phys. Today 48, 34–40 (1995).
[CrossRef]

Yodh, A. G.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

V. Ntziachristos, A. G. Yodh, M. Schnall, B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4, 347–354 (2002).
[CrossRef] [PubMed]

J. P. Culver, V. Ntziachristos, M. J. Holboke, A. G. Yodh, “Optimization of optode arrangements for diffuse optical tomography: a singular-value analysis,” Opt. Lett. 26, 701–703 (2001).
[CrossRef]

Q. Zhu, T. Durduran, V. Ntziachristos, M. Holboke, A. G. Yodh, “Imager that combines near-infrared diffusive light and ultrasound,” Opt. Lett. 24, 1050–1052 (1999).
[CrossRef]

Zhang, Q.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18 (6), 57–75 (2001).
[CrossRef]

Q. Zhang, T. J. Brukilacchio, T. Gaudett, L. Wang, A. Li, D. A. Boas, “Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities,” in Optical Tomography and Spectroscopy of Tissue IV, B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, Proc. SPIE4250, 219–238 (2001).

Zhu, Q.

Zourabian, A.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, D. A. Boas, “Bedside functional imaging of the premature infant brain during passive motor activation,” J. Perinat. Med. 29, 335–343 (2001).
[CrossRef] [PubMed]

Zubkov, L.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

Appl. Opt.

Front. Med. Biol. Eng.

A. Maki, Y. Yamashita, E. Watanabe, H. Koizumi, “Visualizing human motor activity by using non-invasive optical topography,” Front. Med. Biol. Eng. 7, 285–297 (1996).
[PubMed]

IEEE Comput. Sci. Eng.

R. L. Barbour, H. L. Graber, J. Chang, S. S. Barbour, P. C. Koo, R. Aronson, ““MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2(4), 63–77 (1995).
[CrossRef]

IEEE Signal Process. Mag.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18 (6), 57–75 (2001).
[CrossRef]

Inverse Probl.

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41–R93 (1999).
[CrossRef]

M. Belge, M. Kilmer, L. E. Miller, “Efficient determination of multiple regularization parameters in a generalized L-curve framework,” Inverse Probl. 18, 1161–1183 (2002).
[CrossRef]

J. Perinat. Med.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, D. A. Boas, “Bedside functional imaging of the premature infant brain during passive motor activation,” J. Perinat. Med. 29, 335–343 (2001).
[CrossRef] [PubMed]

Med. Phys.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, A. G. Yodh, “Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging,” Med. Phys. 30, 235–247 (2003).
[CrossRef] [PubMed]

Neoplasia

V. Ntziachristos, A. G. Yodh, M. Schnall, B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4, 347–354 (2002).
[CrossRef] [PubMed]

Neuroimage

Y. Hoshi, M. Tamura, “Near-infrared optical detection of sequential brain activation in the prefrontal cortex during mental tasks,” Neuroimage 5, 292–297 (1997).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Phys. Med. Biol.

R. J. Gaudette, D. H. Brooks, C. A. DiMarzio, M. E. Kilmer, E. L. Miller, T. Gaudette, D. A. Boas, “A comparison study of linear reconstruction techniques for diffuse optical tomographic imaging of absorption coefficient,” Phys. Med. Biol. 45, 1051–1070 (2000).
[CrossRef] [PubMed]

Phys. Today

A. Yodh, B. Chance, “Spectroscopy and imaging with diffusing light,” Phys. Today 48, 34–40 (1995).
[CrossRef]

Radio Sci.

O. Arikan, “Regularized inversion of a two-dimensional integral equation with applications in borehole induction measurements,” Radio Sci. 29, 519–538 (1994).
[CrossRef]

Radiology

L. T. Niklason, B. T. Christian, L. E. Niklason, D. B. Kopans, D. E. Castleberry, B. H. Opsahl-Ong, C. E. Landberg, P. J. Slanetz, A. A. Giardino, R. Moore, D. Albagli, M. C. DeJule, P. E. Fitzgerald, D. F. Fobare, B. W. Giambattista, R. F. Kwasnick, J. Liu, S. J. Lubowski, G. E. Possin, J. F. Richotte, C.-Y. Wei, R. F. Wirth, “Digital tomosynthesis in breast imaging,” Radiology 205, 399–406 (1997).
[PubMed]

Other

T. Wu, “Three dimensional mammography reconstruction using low dose projection images, Ph. D. dissertation (Department of Physics, Brandeis University, Waltham, Mass., 2002).

Q. Zhang, T. J. Brukilacchio, T. Gaudett, L. Wang, A. Li, D. A. Boas, “Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities,” in Optical Tomography and Spectroscopy of Tissue IV, B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, Proc. SPIE4250, 219–238 (2001).

P. C. Hansen, Rank-Deficient and Discrete Ill-Posed Problems: Numerical Aspects of Linear Inversion (SIAM Press, Philadelphia, Pa., 1998).

S. R. Arridge, M. Schweiger, “Inverse methods for optical tomography,” in Proceedings of Information Processing in Medical Imaging (IPMI’93), H. H. Barrett, A. F. Gmitro, eds., Vol. 687 of Lecture Notes in Computer Science, (Springer-Verlag, New York, 1993).

M. A. O’Leary, “Imaging with diffuse photon density waves,” Ph.D. dissertation (Department of Physics, Unversity of Pennsylvania, Philadelphia, Pa., 1996).

D. A. Boas, “Diffuse photon probes of structural and dynamical properties of turbid media: theory and biomedical applications,” Ph.D. dissertation (Department of Physics, University of Pennsylvania, Philadelphia, Pa., 1996).

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