Abstract

Accurate and noninvasive measurement of tissue optical properties can be used for biomedical diagnostics and monitoring of tissue analytes. Noninvasive measurement of tissue optical properties (total attenuation and scattering coefficients, optical thickness, etc.) can be performed with the optical coherence tomography (OCT) technique. However, speckle noise substantially deteriorates the accuracy of the measurements with this technique. We studied suppression of speckle noise for accurate measurement of backscattering signal and scattering coefficient with the OCT technique. Our results demonstrate that the precision of measurement of backscattering signals with the OCT technique can be 0.2% for homogeneously scattering media and 0.7% for skin, if spatial averaging of speckle noise is applied. This averaging allows us to achieve the precision of tissue scattering coefficient measurements of approximately ±0.8%. This precision can be further improved by a factor of 2–3, upon optimization of OCT operating parameters.

© 2003 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
In vitro studies toward noninvasive glucose monitoring with optical coherence tomography

Matti Kinnunen, Risto Myllylä, Tiina Jokela, and Seppo Vainio
Appl. Opt. 45(10) 2251-2260 (2006)

Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography

Yuqing Zhang, Guoyong Wu, Huajiang Wei, Zhouyi Guo, Hongqin Yang, Yonghong He, Shusen Xie, and Ying Liu
Biomed. Opt. Express 5(4) 990-999 (2014)

Feasibility analysis of an epidermal glucose sensor based on time-resolved fluorescence

Kamal M. Katika and Laurent Pilon
Appl. Opt. 46(16) 3359-3368 (2007)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (10)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (2)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (13)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription