Abstract

We describe a two-dimensional optical coherence tomography technique with which we were able to obtain multiple longitudinal slices of a biological sample directly in a single Z scan. The system is based on a femtosecond Cr4+:forsterite laser and an infrared camera for wide-field imaging of the sample with a depth resolution of 5 µm. With this imaging apparatus we were able to investigate human skin and mouse ear samples and to observe the different constitutive tissues.

© 2002 Optical Society of America

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
    [CrossRef] [PubMed]
  2. J. M. Schmitt, “Optical coherence tomography (OCT): a review,” IEEE J. Sel. Top. Quantum Electron. 5, 1205–1215 (1999).
    [CrossRef]
  3. W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, J. G. Fujimoto, “In vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett. 24, 1221–1223 (1999).
    [CrossRef]
  4. T. Dresel, G. Häusler, H. Venzke, “Three-dimensional sensing of rough surfaces by coherence radar,” Appl. Opt. 31, 919–925 (1992).
    [CrossRef] [PubMed]
  5. L. Kay, A. Podoleanu, M. Seeger, C. J. Solomon, “A new approach to the measurement and analysis of impact craters,” Int. J. Impact. Eng. 19, 739–753 (1997).
    [CrossRef]
  6. S. Bourquin, P. Seitz, R. P. Salathé, “Optical coherence tomography based on a two-dimensional smart detector array,” Opt. Lett. 26, 512–514 (2001).
    [CrossRef]
  7. E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, H. Saint-Jalmes, “Full-field optical coherence tomography,” Opt. Lett. 23, 244–246 (1998).
    [CrossRef]
  8. G. Jonusauskas, J. Oberlé, C. Rullière, “54-fs, 1-GW, 1-kHz pulse amplification in Cr:forsterite,” Opt. Lett. 23, 1918–1921 (1998).
    [CrossRef]
  9. B. E. Bouma, G. J. Tearney, I. P. Bilinsky, B. Golubovic, J. G. Fujimoto, “Self-phase-modulated Kerr-lens mode-locked Cr:forsterite laser source for optical coherence tomography,” Opt. Lett. 21, 1839–1841 (1996).
    [CrossRef] [PubMed]
  10. E. Abraham, E. Bordenave, N. Tsurumachi, G. Jonusauskas, J. Oberlé, C. Rullière, “Real-time two-dimensional imaging in scattering media by use of a femtosecond Cr4+:forsterite laser,” Opt. Lett. 25, 929–931 (2000).
    [CrossRef]
  11. G. J. Tearney, B. E. Bouma, S. A. Boppart, B. Golubovic, E. A. Swanson, J. G. Fujimoto, “Rapid acquisition of in vivo biological images by use of optical coherence tomography,” Opt. Lett. 21, 1408–1410 (1996).
    [CrossRef] [PubMed]
  12. S. K. Gayen, M. E. Zevallos, M. Alrubaiee, J. M. Evans, R. R. Alfano, “Two-dimensional near-infrared transillumination imaging of biomedical media with a chromium-doped forsterite laser,” Appl. Opt. 37, 5327–5336 (1998).
    [CrossRef]
  13. T. Kreis, Holographic Interferometry: Principles and Methods (Akademie Verlag, Berlin, 1996).
  14. A. M. Rollins, M. D. Kulkarni, S. Yazdanfar, R. Ung-arunyawee, J. A. Izatt, “In vivo video rate optical coherence tomography,” Opt. Express3, 219–229 (1998), http://www.opticsexpress.org .
  15. A. Gh. Podoleanu, J. A. Rogers, D. A. Jackson, “Three-dimensional OCT images from retina and skin,” Opt. Express 7, 292–298 (2000), http://www.opticsexpress.org .
    [CrossRef]

2001 (1)

2000 (2)

1999 (2)

1998 (3)

1997 (1)

L. Kay, A. Podoleanu, M. Seeger, C. J. Solomon, “A new approach to the measurement and analysis of impact craters,” Int. J. Impact. Eng. 19, 739–753 (1997).
[CrossRef]

1996 (2)

1992 (1)

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Abraham, E.

Alfano, R. R.

Alrubaiee, M.

Beaurepaire, E.

Bilinsky, I. P.

Blanchot, L.

Boccara, A. C.

Boppart, S. A.

Bordenave, E.

Bouma, B. E.

Bourquin, S.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Dresel, T.

Drexler, W.

Evans, J. M.

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Fujimoto, J. G.

Gayen, S. K.

Golubovic, B.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Häusler, G.

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Ippen, E. P.

Jackson, D. A.

Jonusauskas, G.

Kärtner, F. X.

Kay, L.

L. Kay, A. Podoleanu, M. Seeger, C. J. Solomon, “A new approach to the measurement and analysis of impact craters,” Int. J. Impact. Eng. 19, 739–753 (1997).
[CrossRef]

Kreis, T.

T. Kreis, Holographic Interferometry: Principles and Methods (Akademie Verlag, Berlin, 1996).

Lebec, M.

Li, X. D.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Morgner, U.

Oberlé, J.

Pitris, C.

Podoleanu, A.

L. Kay, A. Podoleanu, M. Seeger, C. J. Solomon, “A new approach to the measurement and analysis of impact craters,” Int. J. Impact. Eng. 19, 739–753 (1997).
[CrossRef]

Podoleanu, A. Gh.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Rogers, J. A.

Rullière, C.

Saint-Jalmes, H.

Salathé, R. P.

Schmitt, J. M.

J. M. Schmitt, “Optical coherence tomography (OCT): a review,” IEEE J. Sel. Top. Quantum Electron. 5, 1205–1215 (1999).
[CrossRef]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Seeger, M.

L. Kay, A. Podoleanu, M. Seeger, C. J. Solomon, “A new approach to the measurement and analysis of impact craters,” Int. J. Impact. Eng. 19, 739–753 (1997).
[CrossRef]

Seitz, P.

Solomon, C. J.

L. Kay, A. Podoleanu, M. Seeger, C. J. Solomon, “A new approach to the measurement and analysis of impact craters,” Int. J. Impact. Eng. 19, 739–753 (1997).
[CrossRef]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

G. J. Tearney, B. E. Bouma, S. A. Boppart, B. Golubovic, E. A. Swanson, J. G. Fujimoto, “Rapid acquisition of in vivo biological images by use of optical coherence tomography,” Opt. Lett. 21, 1408–1410 (1996).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Tearney, G. J.

Tsurumachi, N.

Venzke, H.

Zevallos, M. E.

Appl. Opt. (2)

IEEE J. Sel. Top. Quantum Electron. (1)

J. M. Schmitt, “Optical coherence tomography (OCT): a review,” IEEE J. Sel. Top. Quantum Electron. 5, 1205–1215 (1999).
[CrossRef]

Int. J. Impact. Eng. (1)

L. Kay, A. Podoleanu, M. Seeger, C. J. Solomon, “A new approach to the measurement and analysis of impact craters,” Int. J. Impact. Eng. 19, 739–753 (1997).
[CrossRef]

Opt. Express (1)

Opt. Lett. (7)

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[CrossRef] [PubMed]

Other (2)

T. Kreis, Holographic Interferometry: Principles and Methods (Akademie Verlag, Berlin, 1996).

A. M. Rollins, M. D. Kulkarni, S. Yazdanfar, R. Ung-arunyawee, J. A. Izatt, “In vivo video rate optical coherence tomography,” Opt. Express3, 219–229 (1998), http://www.opticsexpress.org .

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