Abstract

We present a detailed experimental study concerning quantitative optical property reconstruction of heterogeneous turbid media by use of absolute dc data only. We performed experiments by using tissuelike phantoms in both single-target and multitarget configurations in which variations in target size and optical contrast with the background were explored. Our results show that both scattering and absorption images can be reconstructed quantitatively by use of dc data only, whereas it was impossible to obtain such quantitative information in previously reported studies. We believe that this improvement is primarily a result of the realization of a novel data preprocessing/optimization scheme for accurately determining several critical parameters needed for reconstruction. The use of this data preprocessing/optimization scheme also eliminates the calibration reference measurement previously required for reconstruction. Experimental confirmation of this scheme is given in detail.

© 2000 Optical Society of America

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1999 (7)

1998 (3)

X. Cheng, D. Boas, “Diffuse optical reflection tomography with continuous-wave illumination,” Opt. Express 3, 118–123 (1998), http://epubs.osa.org/opticsexpress .
[CrossRef]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissuelike phantoms,” Phys. Med. Biol. 43, 675–693 (1998).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Frequency-domain near-infrared photo diffusion imaging: initial evaluation in multitarget tissuelike phantoms,” Med. Phys. 25, 183–193 (1998).
[CrossRef] [PubMed]

1997 (7)

1996 (2)

H. Jiang, K. Paulsen, U. Osterberg, B. Pogue, M. Patterson, “Optical image reconstruction using frequency-domain data: simulations and experiments,” J. Opt. Soc. Am. A 13, 253–266 (1996).
[CrossRef]

H. Jiang, K. Paulsen, U. Osterberg, “Optical image reconstruction using DC data: simulations and experiments,” Phys. Med. Biol. 41, 1483–1498 (1996).
[CrossRef] [PubMed]

1995 (4)

K. D. Paulsen, H. Jiang, “Spatially varying optical property reconstruction using a finite-element diffusion equation approximation,” Med. Phys. 22, 691–702 (1995).
[CrossRef] [PubMed]

R. L. Barbour, H. Graber, J. Chang, S. Barbour, P. Koo, R. Aronson, “MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2, 63–77 (1995).
[CrossRef]

M. A. O’Leary, D. A. Boas, B. Chance, A. G. Yodh, “Experimental images of heterogeneous turbid media by frequency-domain diffusing-photon tomography,” Opt. Lett. 20, 426–428 (1995).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, M. S. Patterson, “Simultaneous reconstruction of absorption and scattering profiles in turbid media from near-infrared frequency-domain data,” Opt. Lett. 20, 2128–2130 (1995).
[CrossRef] [PubMed]

1994 (1)

Alfano, R.

Alrubaiee, M.

Aronson, R.

R. L. Barbour, H. Graber, J. Chang, S. Barbour, P. Koo, R. Aronson, “MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2, 63–77 (1995).
[CrossRef]

Arridge, S. R.

S. R. Arridge, M. Schweiger, “Image reconstruction in optical tomography,” Philos. Trans. R. Soc. London Ser. B 352, 717–726 (1997).
[CrossRef]

Barbour, R. L.

R. L. Barbour, H. Graber, J. Chang, S. Barbour, P. Koo, R. Aronson, “MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2, 63–77 (1995).
[CrossRef]

Barbour, S.

R. L. Barbour, H. Graber, J. Chang, S. Barbour, P. Koo, R. Aronson, “MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2, 63–77 (1995).
[CrossRef]

Boas, D.

Boas, D. A.

Cai, W.

Chance, B.

Chang, J.

R. L. Barbour, H. Graber, J. Chang, S. Barbour, P. Koo, R. Aronson, “MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2, 63–77 (1995).
[CrossRef]

Cheng, X.

Colak, S. B.

Dougherty, D.

Downar, T.

Eppstein, M. J.

Fantini, S.

Feng, T.

Gayen, S.

Graber, H.

R. L. Barbour, H. Graber, J. Chang, S. Barbour, P. Koo, R. Aronson, “MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2, 63–77 (1995).
[CrossRef]

Gratton, E.

Iftimia, N.

N. Iftimia, H. Jiang, “Development of a combined optical and fluorescence imaging system in frequency domain for breast cancer detection,” in Biomedical Topical Meetings, Postconference Digest, Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2000), pp. 383–385.

Jiang, H.

H. Jiang, “Optical image reconstruction based on the third-order diffusion equations,” Opt. Express 4, 241–246 (1999), http://epubs.osa.org/opticsexpress .
[CrossRef]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissuelike phantoms,” Phys. Med. Biol. 43, 675–693 (1998).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Frequency-domain near-infrared photo diffusion imaging: initial evaluation in multitarget tissuelike phantoms,” Med. Phys. 25, 183–193 (1998).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Frequency-domain optical image reconstruction in heterogeneous media: an experimental study of single-target detectability,” Appl. Opt. 36, 52–63 (1997).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, B. Pogue, M. Patterson, “Optical image reconstruction using frequency-domain data: simulations and experiments,” J. Opt. Soc. Am. A 13, 253–266 (1996).
[CrossRef]

H. Jiang, K. Paulsen, U. Osterberg, “Optical image reconstruction using DC data: simulations and experiments,” Phys. Med. Biol. 41, 1483–1498 (1996).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, M. S. Patterson, “Simultaneous reconstruction of absorption and scattering profiles in turbid media from near-infrared frequency-domain data,” Opt. Lett. 20, 2128–2130 (1995).
[CrossRef] [PubMed]

K. D. Paulsen, H. Jiang, “Spatially varying optical property reconstruction using a finite-element diffusion equation approximation,” Med. Phys. 22, 691–702 (1995).
[CrossRef] [PubMed]

N. Iftimia, H. Jiang, “Development of a combined optical and fluorescence imaging system in frequency domain for breast cancer detection,” in Biomedical Topical Meetings, Postconference Digest, Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2000), pp. 383–385.

Kaskell, R.

Koo, P.

R. L. Barbour, H. Graber, J. Chang, S. Barbour, P. Koo, R. Aronson, “MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2, 63–77 (1995).
[CrossRef]

Lax, M.

Liu, H.

Matson, C. L.

McAdams, M.

McBride, T.

Melissen, J.

Millane, R.

O’Leary, M. A.

Osterberg, U.

B. W. Pogue, T. McBride, J. Prewitt, U. Osterberg, K. Paulsen, “Spatially variant regularization improves diffuse optical tomography,” Appl. Opt. 38, 2950–2961 (1999).
[CrossRef]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissuelike phantoms,” Phys. Med. Biol. 43, 675–693 (1998).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Frequency-domain near-infrared photo diffusion imaging: initial evaluation in multitarget tissuelike phantoms,” Med. Phys. 25, 183–193 (1998).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Frequency-domain optical image reconstruction in heterogeneous media: an experimental study of single-target detectability,” Appl. Opt. 36, 52–63 (1997).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, B. Pogue, M. Patterson, “Optical image reconstruction using frequency-domain data: simulations and experiments,” J. Opt. Soc. Am. A 13, 253–266 (1996).
[CrossRef]

H. Jiang, K. Paulsen, U. Osterberg, “Optical image reconstruction using DC data: simulations and experiments,” Phys. Med. Biol. 41, 1483–1498 (1996).
[CrossRef] [PubMed]

Osterberg, U. L.

Paasschens, J.

Papaioannou, D.

Patterson, M.

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissuelike phantoms,” Phys. Med. Biol. 43, 675–693 (1998).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Frequency-domain near-infrared photo diffusion imaging: initial evaluation in multitarget tissuelike phantoms,” Med. Phys. 25, 183–193 (1998).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Frequency-domain optical image reconstruction in heterogeneous media: an experimental study of single-target detectability,” Appl. Opt. 36, 52–63 (1997).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, B. Pogue, M. Patterson, “Optical image reconstruction using frequency-domain data: simulations and experiments,” J. Opt. Soc. Am. A 13, 253–266 (1996).
[CrossRef]

Patterson, M. S.

Paulsen, K.

B. W. Pogue, T. McBride, J. Prewitt, U. Osterberg, K. Paulsen, “Spatially variant regularization improves diffuse optical tomography,” Appl. Opt. 38, 2950–2961 (1999).
[CrossRef]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Frequency-domain near-infrared photo diffusion imaging: initial evaluation in multitarget tissuelike phantoms,” Med. Phys. 25, 183–193 (1998).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissuelike phantoms,” Phys. Med. Biol. 43, 675–693 (1998).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Frequency-domain optical image reconstruction in heterogeneous media: an experimental study of single-target detectability,” Appl. Opt. 36, 52–63 (1997).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, B. Pogue, M. Patterson, “Optical image reconstruction using frequency-domain data: simulations and experiments,” J. Opt. Soc. Am. A 13, 253–266 (1996).
[CrossRef]

H. Jiang, K. Paulsen, U. Osterberg, “Optical image reconstruction using DC data: simulations and experiments,” Phys. Med. Biol. 41, 1483–1498 (1996).
[CrossRef] [PubMed]

Paulsen, K. D.

Pine, D.

B. Tromberg, A. Yodh, E. Sevick-Muraca, D. Pine, “Diffusing photons in turbid media: introduction,” Appl. Opt. 36, 9 (1997).
[CrossRef]

A. Yodh, B. Tromberg, E. Sevick-Muraca, D. Pine, “Diffusing photons in turbid media: introduction,” J. Opt. Soc. Am. A 14, 136 (1997).

Pogue, B.

Pogue, B. W.

Prewitt, J.

Schomberg, H.

Schweiger, M.

S. R. Arridge, M. Schweiger, “Image reconstruction in optical tomography,” Philos. Trans. R. Soc. London Ser. B 352, 717–726 (1997).
[CrossRef]

Scotland, J.

Sevick-Muraca, E.

Svaasand, L.

tHooft, G.

Tromberg, B.

Troy, T.

Tsay, T.

van Asten, N.

vander Mark, M.

Walker, S. A.

Webb, K.

Xu, M.

Ye, J. C.

Yodh, A.

A. Yodh, B. Tromberg, E. Sevick-Muraca, D. Pine, “Diffusing photons in turbid media: introduction,” J. Opt. Soc. Am. A 14, 136 (1997).

B. Tromberg, A. Yodh, E. Sevick-Muraca, D. Pine, “Diffusing photons in turbid media: introduction,” Appl. Opt. 36, 9 (1997).
[CrossRef]

Yodh, A. G.

Zevallos, M.

Appl. Opt. (7)

IEEE Comput. Sci. Eng. (1)

R. L. Barbour, H. Graber, J. Chang, S. Barbour, P. Koo, R. Aronson, “MRI-guided optical tomography: prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2, 63–77 (1995).
[CrossRef]

J. Opt. Soc. Am. A (6)

Med. Phys. (2)

K. D. Paulsen, H. Jiang, “Spatially varying optical property reconstruction using a finite-element diffusion equation approximation,” Med. Phys. 22, 691–702 (1995).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Frequency-domain near-infrared photo diffusion imaging: initial evaluation in multitarget tissuelike phantoms,” Med. Phys. 25, 183–193 (1998).
[CrossRef] [PubMed]

Opt. Express (3)

Opt. Lett. (2)

Philos. Trans. R. Soc. London Ser. B (1)

S. R. Arridge, M. Schweiger, “Image reconstruction in optical tomography,” Philos. Trans. R. Soc. London Ser. B 352, 717–726 (1997).
[CrossRef]

Phys. Med. Biol. (2)

H. Jiang, K. Paulsen, U. Osterberg, “Optical image reconstruction using DC data: simulations and experiments,” Phys. Med. Biol. 41, 1483–1498 (1996).
[CrossRef] [PubMed]

H. Jiang, K. Paulsen, U. Osterberg, M. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissuelike phantoms,” Phys. Med. Biol. 43, 675–693 (1998).
[CrossRef] [PubMed]

Other (1)

N. Iftimia, H. Jiang, “Development of a combined optical and fluorescence imaging system in frequency domain for breast cancer detection,” in Biomedical Topical Meetings, Postconference Digest, Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2000), pp. 383–385.

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