We have developed a laser-pulse mammograph capable of recording optical mammograms within ∼3 min by measuring time-resolved transmittance at each of typically 1500 scan positions, 2.5 mm apart. As a first application two patients who have tumors were investigated successfully. From measured distributions of times of flight of photons corrected for edge effects we derived (1) characteristic quantities, such as photon counts in selected time windows, to generate optical mammograms; (2) effective transport scattering and absorption coefficients of breast tissue at each scan position, assuming the breast to be homogeneous; and (3) optical properties of a selected tumor by applying the theory of diffraction of photon density waves by spherical inhomogeneity. Mammograms recorded at different lateral offsets between source and detector fiber were used to estimate the depth of inhomogeneities.
© 1999 Optical Society of AmericaFull Article | PDF Article
OSA Recommended Articles
B. Wassermann, A. Kummrow, K.T. Moesta, D. Grosenick, J. Mucke, H. Wabnitz, M. MÖller, R. Macdonald, P. M. Schlag, and H. Rinneberg.
Opt. Express 13(21) 8571-8583 (2005)
Yang Yu, Ning Liu, Angelo Sassaroli, and Sergio Fantini
Appl. Opt. 48(10) D225-D235 (2009)
Rosario Esposito, Sergio De Nicola, Marco Brambilla, Antonio Pifferi, Lorenzo Spinelli, and Maria Lepore
Opt. Express 16(22) 17667-17681 (2008)