Abstract

An amplitude-sensitive optical heterodyne polarimeter was set up to monitor noninvasively the aqueous glucose concentration in a rabbit’s eye. A Zeeman laser in conjunction with a Glan–Thompson analyzer was used to generate an optical heterodyne signal. The amplitude of the heterodyne signal linearly related to the optical rotation angle of the aqueous glucose. The concentration of the aqueous glucose in a rabbit’s eyeball was measured in vivo. There was a 30-min time delay between observations of aqueous glucose and blood glucose. The detection capability and the reproducibility of the experiment are demonstrated and discussed.

© 1998 Optical Society of America

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  2. W. F. March, B. Rabinovitch, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part II. Animal studies and the scleral lens,” Diabetes Care 5, 259–265 (1982).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef] [PubMed]

1997 (3)

G. L. Cote, B. D. Cameron, “Noninvasive polarimetric measurement of glucose in cell culture media,” J. Biomed. Opt. 2, 275–281 (1997).
[CrossRef] [PubMed]

C. Chou, Y. C. Huang, C. M. Feng, M. Chang, “Amplitude sensitive optical heterodyne and phase lock-in technique on small optical rotation angle detection of chiral liquid,” Jpn. J. Appl. Phys. 36, 356–359 (1997).
[CrossRef]

J. T. Bruulserna, J. E. Hayward, T. J. Farrell, M. S. Pattersson, L. Heinemann, M. Berger, T. Koschinsky, J. Sandahl-Christiansen, H. Orskov, M. Essenpreis, G. Schmelzeisen-Redekev, D. Boker, “Correlation between blood glucose concentration in diabetics and noninvasively measured tissue optical scattering coefficient,” Opt. Lett. 22, 190–192 (1997).
[CrossRef]

1996 (1)

1994 (2)

1991 (1)

M. Toida, M. Kondo, T. Ichimura, H. Inaba, “Two-dimensional coherent detection imaging in multiple scattering media based on the directional resolution capability of the optical heterodyne method,” Appl. Phys. B 52, 391–394 (1991).
[CrossRef]

1982 (3)

D. A. Gough, “The composition and optical rotary dispersion of bovine aqueous humor,” Diabetes Care 5, 266–270 (1982).
[CrossRef] [PubMed]

B. Rabinovitch, W. F. March, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part I. Measurement of very small optical rotations,” Diabetes Care 5, 254–258 (1982).
[CrossRef] [PubMed]

W. F. March, B. Rabinovitch, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part II. Animal studies and the scleral lens,” Diabetes Care 5, 259–265 (1982).
[CrossRef] [PubMed]

1975 (1)

Adams, R. L.

B. Rabinovitch, W. F. March, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part I. Measurement of very small optical rotations,” Diabetes Care 5, 254–258 (1982).
[CrossRef] [PubMed]

W. F. March, B. Rabinovitch, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part II. Animal studies and the scleral lens,” Diabetes Care 5, 259–265 (1982).
[CrossRef] [PubMed]

Berger, M.

Bocker, D.

Boker, D.

Bruulserna, J. T.

Cameron, B. D.

G. L. Cote, B. D. Cameron, “Noninvasive polarimetric measurement of glucose in cell culture media,” J. Biomed. Opt. 2, 275–281 (1997).
[CrossRef] [PubMed]

Chang, M.

C. Chou, Y. C. Huang, C. M. Feng, M. Chang, “Amplitude sensitive optical heterodyne and phase lock-in technique on small optical rotation angle detection of chiral liquid,” Jpn. J. Appl. Phys. 36, 356–359 (1997).
[CrossRef]

Chou, C.

C. Chou, Y. C. Huang, C. M. Feng, M. Chang, “Amplitude sensitive optical heterodyne and phase lock-in technique on small optical rotation angle detection of chiral liquid,” Jpn. J. Appl. Phys. 36, 356–359 (1997).
[CrossRef]

Cohen, S. C.

Cope, M.

Cote, G. L.

G. L. Cote, B. D. Cameron, “Noninvasive polarimetric measurement of glucose in cell culture media,” J. Biomed. Opt. 2, 275–281 (1997).
[CrossRef] [PubMed]

Essenpreis, M.

Fantini, S.

Farrell, T. J.

Feng, C. M.

C. Chou, Y. C. Huang, C. M. Feng, M. Chang, “Amplitude sensitive optical heterodyne and phase lock-in technique on small optical rotation angle detection of chiral liquid,” Jpn. J. Appl. Phys. 36, 356–359 (1997).
[CrossRef]

Franceschini, M. A.

Gough, D. A.

D. A. Gough, “The composition and optical rotary dispersion of bovine aqueous humor,” Diabetes Care 5, 266–270 (1982).
[CrossRef] [PubMed]

Gratton, E.

Hayward, J. E.

Heinemann, L.

Huang, Y. C.

C. Chou, Y. C. Huang, C. M. Feng, M. Chang, “Amplitude sensitive optical heterodyne and phase lock-in technique on small optical rotation angle detection of chiral liquid,” Jpn. J. Appl. Phys. 36, 356–359 (1997).
[CrossRef]

Ichimura, T.

M. Toida, M. Kondo, T. Ichimura, H. Inaba, “Two-dimensional coherent detection imaging in multiple scattering media based on the directional resolution capability of the optical heterodyne method,” Appl. Phys. B 52, 391–394 (1991).
[CrossRef]

Inaba, H.

M. Toida, M. Kondo, T. Ichimura, H. Inaba, “Two-dimensional coherent detection imaging in multiple scattering media based on the directional resolution capability of the optical heterodyne method,” Appl. Phys. B 52, 391–394 (1991).
[CrossRef]

Kohl, M.

Kondo, M.

M. Toida, M. Kondo, T. Ichimura, H. Inaba, “Two-dimensional coherent detection imaging in multiple scattering media based on the directional resolution capability of the optical heterodyne method,” Appl. Phys. B 52, 391–394 (1991).
[CrossRef]

Koschinsky, T.

Maier, J. S.

March, W. F.

W. F. March, B. Rabinovitch, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part II. Animal studies and the scleral lens,” Diabetes Care 5, 259–265 (1982).
[CrossRef] [PubMed]

B. Rabinovitch, W. F. March, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part I. Measurement of very small optical rotations,” Diabetes Care 5, 254–258 (1982).
[CrossRef] [PubMed]

Mitsui, T.

Orskov, H.

Pattersson, M. S.

Rabinovitch, B.

B. Rabinovitch, W. F. March, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part I. Measurement of very small optical rotations,” Diabetes Care 5, 254–258 (1982).
[CrossRef] [PubMed]

W. F. March, B. Rabinovitch, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part II. Animal studies and the scleral lens,” Diabetes Care 5, 259–265 (1982).
[CrossRef] [PubMed]

Sakurai, K.

Sandahl-Christiansen, J.

Schmelzeisen-Redekev, G.

Stamper, R. L.

R. L. Stamper, “Aqueous humor: secretion and dynamics,” in Physiology of the Human Eye and Visual System, R. E. Records, ed. (Harper & Row, Hagerstown, Md., 1979), pp. 156–182.

Toida, M.

M. Toida, M. Kondo, T. Ichimura, H. Inaba, “Two-dimensional coherent detection imaging in multiple scattering media based on the directional resolution capability of the optical heterodyne method,” Appl. Phys. B 52, 391–394 (1991).
[CrossRef]

Walker, S. A.

Appl. Opt. (2)

Appl. Phys. B (1)

M. Toida, M. Kondo, T. Ichimura, H. Inaba, “Two-dimensional coherent detection imaging in multiple scattering media based on the directional resolution capability of the optical heterodyne method,” Appl. Phys. B 52, 391–394 (1991).
[CrossRef]

Diabetes Care (3)

D. A. Gough, “The composition and optical rotary dispersion of bovine aqueous humor,” Diabetes Care 5, 266–270 (1982).
[CrossRef] [PubMed]

B. Rabinovitch, W. F. March, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part I. Measurement of very small optical rotations,” Diabetes Care 5, 254–258 (1982).
[CrossRef] [PubMed]

W. F. March, B. Rabinovitch, R. L. Adams, “Noninvasive glucose monitoring of the aqueous humor of the eye: Part II. Animal studies and the scleral lens,” Diabetes Care 5, 259–265 (1982).
[CrossRef] [PubMed]

J. Biomed. Opt. (1)

G. L. Cote, B. D. Cameron, “Noninvasive polarimetric measurement of glucose in cell culture media,” J. Biomed. Opt. 2, 275–281 (1997).
[CrossRef] [PubMed]

Jpn. J. Appl. Phys. (1)

C. Chou, Y. C. Huang, C. M. Feng, M. Chang, “Amplitude sensitive optical heterodyne and phase lock-in technique on small optical rotation angle detection of chiral liquid,” Jpn. J. Appl. Phys. 36, 356–359 (1997).
[CrossRef]

Opt. Lett. (3)

Other (1)

R. L. Stamper, “Aqueous humor: secretion and dynamics,” in Physiology of the Human Eye and Visual System, R. E. Records, ed. (Harper & Row, Hagerstown, Md., 1979), pp. 156–182.

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