Abstract

The relationship between optical properties and image contrast in confocal imaging is investigated. A Monte Carlo simulation has been developed to analyze the effects of changes in scattering, index of refraction, and absorption in a three-layer medium. Contrast was calculated from the computed signal-to-background ratios for changes in tissue optical properties. Results show that the largest source of contrast is changes in refractive index.

© 1996 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Penetration depth limits of in vivo confocal reflectance imaging

Colin L. Smithpeter, Andrew K. Dunn, A. J. Welch, and Rebecca Richards-Kortum
Appl. Opt. 37(13) 2749-2754 (1998)

Efficient Monte Carlo simulation of confocal microscopy in biological tissue

J. M. Schmitt and K. Ben-Letaief
J. Opt. Soc. Am. A 13(5) 952-961 (1996)

Improved importance sampling for Monte Carlo simulation of time-domain optical coherence tomography

Ivan T. Lima, Anshul Kalra, and Sherif S. Sherif
Biomed. Opt. Express 2(5) 1069-1081 (2011)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (10)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (1)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (6)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription