## Abstract

This article presents the theoretical background of an azimuthally stable method of Jones-matrix mapping of histological sections of a uterine wall biopsy on the basis of spatial-frequency selection of the mechanisms of linear and circular birefringence. The diagnostic application of a new correlation parameter—a complex degree of mutual anisotropy—is analytically substantiated. The method of measuring coordinate distributions of a complex degree of mutual anisotropy with further spatial filtration of their high- and low-frequency components is developed. The interconnections of such distributions with linear and circular birefringence parameters of the uterine-wall-endometrium histological sections are found. The comparative results of measuring the coordinate distributions of a complex degree of mutual anisotropy formed by fibrillar networks of myosin and collagen fibrils of uterus wall tissue of different pathological states—pre-cancer (dysplasia) and cancer (adenocarcinoma)—are shown. The values and ranges of change of the statistical (moments of the first to fourth orders) parameters of complex degree of mutual-anisotropy coordinate distributions are studied. The objective criteria of diagnosing the pathology and differentiation of its severity degree are determined.

© 2014 Optical Society of America

Full Article | PDF Article**OSA Recommended Articles**

Yu. A. Ushenko, V. T. Bachynsky, O. Ya. Vanchulyak, A. V. Dubolazov, M. S. Garazdyuk, and V. A. Ushenko

Appl. Opt. **55**(12) B113-B119 (2016)

Yu. A. Ushenko, A. D. Arkhelyuk, M. I. Sidor, V. T. Bachynskyi, and O. Yu. Wanchuliak

Appl. Opt. **53**(10) B181-B191 (2014)

V. A. Ushenko, O. V. Dubolazov, and A. O. Karachevtsev

Appl. Opt. **53**(10) B128-B139 (2014)