Sensitivity of spatially resolved reflectance signals to coincident variations in tissue optical properties

Dizem Arifler

doi:10.1364/AO.49.004310

Sensitivity of spatially resolved reflectance signals to coincident variations in tissue optical properties

Dizem Arifler

Applied Optics
Vol. 49,
Issue 22,
pp. 4310-4320
(2010)
•https://doi.org/10.1364/AO.49.004310

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Dizem Arifler, "Sensitivity of spatially resolved reflectance signals to coincident variations in tissue optical properties," Appl. Opt. 49, 4310-4320 (2010)

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Related Topics
Table of Contents Category
- Medical Optics and Biotechnology
Optics & Photonics Topics
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The topics in this list come from the OSA Optics and Photonics Topics applied to this article.
Previously assigned OCIS codes
- Light propagation in tissues (170.3660)
- Medical optics instrumentation (170.3890)
- Optical diagnostics for medicine (170.4580)
- Spectroscopy, tissue diagnostics (170.6510)

About this Article
History
- Original Manuscript: November 11, 2009
- Revised Manuscript: June 1, 2010
- Manuscript Accepted: June 25, 2010
- Published: July 30, 2010
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Abstract

Canonical correlation analysis, a multivariate statistical technique, was used to investigate the degree of association between tissue optical properties and spatially resolved reflectance signals. Monte Carlo modeling was employed to simulate signals corresponding to different combinations of optical properties and these data sets were fed as input to statistical analysis. The results show that it is possible to adjust the separation and angular orientation of source and detector fibers such that the effect of a particular optical property will be augmented among coincident variations in other properties. The trends observed exhibit differences when compared with a conventional univariate sensitivity analysis in which only a single property is varied whereas all other parameters of interest are kept constant.

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	Canonical Correlations
$\hat{ρ}$	0.93	0.80	0.32
	Canonical Loadings
$z^{(1)}$ variables	${\hat{U}}_{1}$	${\hat{U}}_{2}$	${\hat{U}}_{3}$
$μ_{s}^{*}$	0.74	$- 0.36$	0.56
$μ_{a}^{*}$	$- 0.47$	$- 0.88$	0.06
$g^{*}$	$- 0.47$	0.31	0.82

	Canonical Correlations
$\hat{ρ}$	0.97	0.90	0.34
	Canonical Loadings
$z^{(1)}$ variables	${\hat{U}}_{1}$	${\hat{U}}_{2}$	${\hat{U}}_{3}$
$μ_{s}^{*}$	0.74	$- 0.43$	0.52
$μ_{a}^{*}$	$- 0.56$	$- 0.82$	0.11
$g^{*}$	$- 0.38$	0.37	0.85

	Canonical Correlations
$\hat{ρ}$	0.93	0.80	0.32
	Canonical Loadings
$z^{(1)}$ variables	${\hat{U}}_{1}$	${\hat{U}}_{2}$	${\hat{U}}_{3}$
$μ_{s}^{*}$	0.74	$- 0.36$	0.56
$μ_{a}^{*}$	$- 0.47$	$- 0.88$	0.06
$g^{*}$	$- 0.47$	0.31	0.82

	Canonical Correlations
$\hat{ρ}$	0.97	0.90	0.34
	Canonical Loadings
$z^{(1)}$ variables	${\hat{U}}_{1}$	${\hat{U}}_{2}$	${\hat{U}}_{3}$
$μ_{s}^{*}$	0.74	$- 0.43$	0.52
$μ_{a}^{*}$	$- 0.56$	$- 0.82$	0.11
$g^{*}$	$- 0.38$	0.37	0.85

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