Abstract

Handheld-probe-based optical imagers are a popular approach toward breast imaging because of their potential portability and maximum patient comfort. A novel handheld-probe-based optical imager has been developed and its feasibility for three-dimensional fluorescence tomographic imaging demonstrated. Extensive tomography studies were performed on large slab phantoms (650ml) to assess the performance limits of the handheld imager. Experiments were performed by using different target volumes (0.10.45cm3), target depths (13cm), and fluorescence (Indocyanine Green) absorption contrast ratios in a nonfluorescing (10) and constant fluorescing backgrounds (10001 to 51). The estimated sensitivity and specificity of the handheld imager are 43% and 95%, respectively.

© 2009 Optical Society of America

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