Abstract

We present a two-step reconstruction method that can qualitatively and quantitatively improve the reconstruction of tissue refractive index (RI) distribution by phase-contrast diffuse optical tomography (PCDOT). In this two-step method, we first recover the distribution of tissue absorption and scattering coefficients by conventional diffuse optical tomography to obtain the geometrical information of lesions, allowing the incorporation of geometrical information as a priori in the PCDOT reconstruction using a locally refined mesh. The method is validated by a series of phantom experiments and evaluated using in vivo data from 42 human subjects. The results demonstrate clear contrast of RI between the lesion and the surroundings, making the image interpretation straightforward. The sensitivity and specificity from these 42 cases are both 81% when RI is used as an imaging parameter for distinguishing between malignant and benign lesions.

© 2009 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Sensitivity of MRI-guided near-infrared spectroscopy clinical breast exam data and its impact on diagnostic performance

Michael A. Mastanduno, Junqing Xu, Fadi El-Ghussein, Shudong Jiang, Hong Yin, Yan Zhao, Kelly E. Michaelsen, Ke Wang, Fang Ren, Brian W. Pogue, and Keith D. Paulsen
Biomed. Opt. Express 5(9) 3103-3115 (2014)

Three-dimensional time-resolved optical mammography of the uncompressed breast

Louise C. Enfield, Adam P. Gibson, Nicholas L. Everdell, David T. Delpy, Martin Schweiger, Simon R. Arridge, Caroline Richardson, Mohammad Keshtgar, Michael Douek, and Jeremy C. Hebden
Appl. Opt. 46(17) 3628-3638 (2007)

Direct regularization from co-registered anatomical images for MRI-guided near-infrared spectral tomographic image reconstruction

Limin Zhang, Yan Zhao, Shudong Jiang, Brian W. Pogue, and Keith D. Paulsen
Biomed. Opt. Express 6(9) 3618-3630 (2015)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (2)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (5)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription