Abstract

We investigated the effects of operator-applied force on diffuse optical spectroscopy (DOS) by integrating a force transducer into the handheld probe. Over the typical range of contact forces measured in the breasts of eight patients, absorption and reduced scattering coefficients (650 to 1000 nm) variance was 3.1 ± 1.0% and 1.0 ± 0.4%. For trained operators, we observed <5% variation in hemoglobin and <2% variation in water and lipids. Contact force is not a significant source of variation, most likely because of a relatively wide probe surface area and the stability of the DOS method for calculating tissue optical properties.

© 2009 Optical Society of America

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    [CrossRef]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef]

2007 (5)

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

R. X. Xu, D. C. Young, J. J. Mao, and S. P. Povoski, “A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions,” Breast Cancer Res. 9, R88 (2007).
[CrossRef]

A. Cerussi, D. Hsiang, N. Shah, M. Compton, R. Mehta, A. F. Durkin, and B. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

2006 (4)

S. A. Carp, T. Kauffman, Q. Fang, E. Rafferty, R. Moore, D. Kopans, and D. Boas, “Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements,” J. Biomed. Opt. 11, 064016 (2006).
[CrossRef]

E. Lazarus, M. B. Mainiero, B. Schepps, S. L. Koelliker, and L. S. Livingston, “BI-RADS lexicon for US and mammography: interobserver variability and positive predictive value,” Radiology (Oak Brook, Ill.) 239, 385-391 (2006).
[CrossRef]

J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg, and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27, 757-767 (2006).
[CrossRef]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

2005 (4)

Q. Zhu, E. B. Cronin, A. A. Currier, H. S. Vine, M. Huang, N. Chen, and C. Xu, “Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction,” Radiology (Oak Brook, Ill.) 237, 57-66 (2005).
[CrossRef]

S. Nioka, S. Wen, J. Zhang, J. Du, X. Intes, Z. Zhao, and B. Chance, “Simulation study of breast tissue hemodynamics during pressure perturbation,” Adv. Exp. Med. Biol. 566, 17-22 (2005).
[CrossRef]

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915-2917 (2005).
[CrossRef]

2004 (2)

H. J. Finberg, “Whither (wither?) the ultrasound specialist?,” J. Ultrasound Med. 23, 1543-1547 (2004).

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef]

2003 (2)

S. L. Meeks, J. M. Buatti, L. G. Bouchet, F. J. Bova, T. C. Ryken, E. C. Pennington, K. M. Anderson, and W. A. Friedman, “Ultrasound-guided extracranial radiosurgery: technique and application,” Int. J. Radiat. Oncol. Biol. Phys. 55, 1092-1101 (2003).
[CrossRef]

S. Jiang, B. W. Pogue, K. D. Paulsen, C. Kogel, and S. P. Poplack, “In vivo near-infrared spectral detection of pressure-induced changes in breast tissue,” Opt. Lett. 28, 1212-1214 (2003).
[CrossRef]

2002 (1)

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

2000 (2)

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, “Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy,” Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39, 6498-6507 (2000).
[CrossRef]

1993 (1)

1991 (1)

W. G. Zijlstra, A. Buursma, and W. P. Meeuwsen-van der Roest, “Absorption spectra of human fetal and adult oxyhemoglobin, de-oxyhemoglobin, carboxyhemoglobin, and methemoglobin,” Clin. Chem. 37, 1633-1638 (1991).

Anderson, E.

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, “Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy,” Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

Anderson, K. M.

S. L. Meeks, J. M. Buatti, L. G. Bouchet, F. J. Bova, T. C. Ryken, E. C. Pennington, K. M. Anderson, and W. A. Friedman, “Ultrasound-guided extracranial radiosurgery: technique and application,” Int. J. Radiat. Oncol. Biol. Phys. 55, 1092-1101 (2003).
[CrossRef]

Au, S.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, and R. Richards-Kortum, “Design of a multispectral digital colposcope,” in Advanced Biomedical and Clinical Diagnostic Systems V (SPIE, 2007).

Berger, A. J.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39, 6498-6507 (2000).
[CrossRef]

Bevilacqua, F.

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39, 6498-6507 (2000).
[CrossRef]

Boas, D.

S. A. Carp, T. Kauffman, Q. Fang, E. Rafferty, R. Moore, D. Kopans, and D. Boas, “Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements,” J. Biomed. Opt. 11, 064016 (2006).
[CrossRef]

Boas, D. A.

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

Bouchet, L. G.

S. L. Meeks, J. M. Buatti, L. G. Bouchet, F. J. Bova, T. C. Ryken, E. C. Pennington, K. M. Anderson, and W. A. Friedman, “Ultrasound-guided extracranial radiosurgery: technique and application,” Int. J. Radiat. Oncol. Biol. Phys. 55, 1092-1101 (2003).
[CrossRef]

Bova, F. J.

S. L. Meeks, J. M. Buatti, L. G. Bouchet, F. J. Bova, T. C. Ryken, E. C. Pennington, K. M. Anderson, and W. A. Friedman, “Ultrasound-guided extracranial radiosurgery: technique and application,” Int. J. Radiat. Oncol. Biol. Phys. 55, 1092-1101 (2003).
[CrossRef]

Boverman, G.

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

Brenner, M.

J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg, and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27, 757-767 (2006).
[CrossRef]

Briest, S.

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

Brooks, D. H.

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

Buatti, J. M.

S. L. Meeks, J. M. Buatti, L. G. Bouchet, F. J. Bova, T. C. Ryken, E. C. Pennington, K. M. Anderson, and W. A. Friedman, “Ultrasound-guided extracranial radiosurgery: technique and application,” Int. J. Radiat. Oncol. Biol. Phys. 55, 1092-1101 (2003).
[CrossRef]

Butler, J.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

Buursma, A.

W. G. Zijlstra, A. Buursma, and W. P. Meeuwsen-van der Roest, “Absorption spectra of human fetal and adult oxyhemoglobin, de-oxyhemoglobin, carboxyhemoglobin, and methemoglobin,” Clin. Chem. 37, 1633-1638 (1991).

Cardeno, M.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, and R. Richards-Kortum, “Design of a multispectral digital colposcope,” in Advanced Biomedical and Clinical Diagnostic Systems V (SPIE, 2007).

Carp, S. A.

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

S. A. Carp, T. Kauffman, Q. Fang, E. Rafferty, R. Moore, D. Kopans, and D. Boas, “Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements,” J. Biomed. Opt. 11, 064016 (2006).
[CrossRef]

Cerussi, A.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

A. Cerussi, D. Hsiang, N. Shah, M. Compton, R. Mehta, A. F. Durkin, and B. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

S. Kukreti, A. Cerussi, V. Tanamai, B. Tromberg, M. Rita, H. David, and E. Gratton, “Intrinsic near-infrared spectroscopic biomarkers applied for evaluation of final pathological response to neaoadjuvant chemotherapy,” in Breast Cancer Research and Treatment (2007), p. S250.

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

W. Tanamai, A. Cerussi, D. Hsiang, R. Mehta, and B. J. Tromberg, “Assessing final pathological response to neoadjuvant chemotherapy using diffuse optical spectroscopy,” in Breast Cancer Research and Treatment (2007), p. S218.

Cerussi, A. E.

J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg, and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27, 757-767 (2006).
[CrossRef]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39, 6498-6507 (2000).
[CrossRef]

N. Shah S., A. E. Cerussi, D. Gordon, A. Durkin, B. Hill, M. Compton, L. Wenzel, and B. J. Tromberg, “Integration of diffuse optical technology into clinical settings for breast health applications,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), p. SC2.

Chance, B.

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

S. Nioka, S. Wen, J. Zhang, J. Du, X. Intes, Z. Zhao, and B. Chance, “Simulation study of breast tissue hemodynamics during pressure perturbation,” Adv. Exp. Med. Biol. 566, 17-22 (2005).
[CrossRef]

Chen, N.

Q. Zhu, E. B. Cronin, A. A. Currier, H. S. Vine, M. Huang, N. Chen, and C. Xu, “Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction,” Radiology (Oak Brook, Ill.) 237, 57-66 (2005).
[CrossRef]

Choe, R.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915-2917 (2005).
[CrossRef]

Chylek, P.

Compton, M.

A. Cerussi, D. Hsiang, N. Shah, M. Compton, R. Mehta, A. F. Durkin, and B. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

N. Shah S., A. E. Cerussi, D. Gordon, A. Durkin, B. Hill, M. Compton, L. Wenzel, and B. J. Tromberg, “Integration of diffuse optical technology into clinical settings for breast health applications,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), p. SC2.

Conant, E. F.

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

Coquoz, O.

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, “Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy,” Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

Cronin, E. B.

Q. Zhu, E. B. Cronin, A. A. Currier, H. S. Vine, M. Huang, N. Chen, and C. Xu, “Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction,” Radiology (Oak Brook, Ill.) 237, 57-66 (2005).
[CrossRef]

Currier, A. A.

Q. Zhu, E. B. Cronin, A. A. Currier, H. S. Vine, M. Huang, N. Chen, and C. Xu, “Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction,” Radiology (Oak Brook, Ill.) 237, 57-66 (2005).
[CrossRef]

Czerniecki, B. J.

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915-2917 (2005).
[CrossRef]

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

David, H.

S. Kukreti, A. Cerussi, V. Tanamai, B. Tromberg, M. Rita, H. David, and E. Gratton, “Intrinsic near-infrared spectroscopic biomarkers applied for evaluation of final pathological response to neaoadjuvant chemotherapy,” in Breast Cancer Research and Treatment (2007), p. S250.

DeMicco, E.

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

Du, J.

S. Nioka, S. Wen, J. Zhang, J. Du, X. Intes, Z. Zhao, and B. Chance, “Simulation study of breast tissue hemodynamics during pressure perturbation,” Adv. Exp. Med. Biol. 566, 17-22 (2005).
[CrossRef]

Durduran, T.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915-2917 (2005).
[CrossRef]

Durkin, A.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

N. Shah S., A. E. Cerussi, D. Gordon, A. Durkin, B. Hill, M. Compton, L. Wenzel, and B. J. Tromberg, “Integration of diffuse optical technology into clinical settings for breast health applications,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), p. SC2.

Durkin, A. F.

A. Cerussi, D. Hsiang, N. Shah, M. Compton, R. Mehta, A. F. Durkin, and B. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

Eker, C.

C. Eker, “Optical characterization of tissue for medical diagnostics,” Ph.D. thesis (Lund Institute of Technology, 1999).

Fang, Q.

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

S. A. Carp, T. Kauffman, Q. Fang, E. Rafferty, R. Moore, D. Kopans, and D. Boas, “Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements,” J. Biomed. Opt. 11, 064016 (2006).
[CrossRef]

Finberg, H. J.

H. J. Finberg, “Whither (wither?) the ultrasound specialist?,” J. Ultrasound Med. 23, 1543-1547 (2004).

Fishkin, J. B.

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, “Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy,” Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

Follen, M.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, and R. Richards-Kortum, “Design of a multispectral digital colposcope,” in Advanced Biomedical and Clinical Diagnostic Systems V (SPIE, 2007).

Friedman, W. A.

S. L. Meeks, J. M. Buatti, L. G. Bouchet, F. J. Bova, T. C. Ryken, E. C. Pennington, K. M. Anderson, and W. A. Friedman, “Ultrasound-guided extracranial radiosurgery: technique and application,” Int. J. Radiat. Oncol. Biol. Phys. 55, 1092-1101 (2003).
[CrossRef]

Gelfand, D. V.

J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg, and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27, 757-767 (2006).
[CrossRef]

Gibbs, J.

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

Gordon, D.

N. Shah S., A. E. Cerussi, D. Gordon, A. Durkin, B. Hill, M. Compton, L. Wenzel, and B. J. Tromberg, “Integration of diffuse optical technology into clinical settings for breast health applications,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), p. SC2.

Gratton, E.

S. Kukreti, A. Cerussi, V. Tanamai, B. Tromberg, M. Rita, H. David, and E. Gratton, “Intrinsic near-infrared spectroscopic biomarkers applied for evaluation of final pathological response to neaoadjuvant chemotherapy,” in Breast Cancer Research and Treatment (2007), p. S250.

Hattangadi, J.

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

Hill, B.

N. Shah S., A. E. Cerussi, D. Gordon, A. Durkin, B. Hill, M. Compton, L. Wenzel, and B. J. Tromberg, “Integration of diffuse optical technology into clinical settings for breast health applications,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), p. SC2.

Holcombe, R. F.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

Hsiang, D.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

A. Cerussi, D. Hsiang, N. Shah, M. Compton, R. Mehta, A. F. Durkin, and B. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

W. Tanamai, A. Cerussi, D. Hsiang, R. Mehta, and B. J. Tromberg, “Assessing final pathological response to neoadjuvant chemotherapy using diffuse optical spectroscopy,” in Breast Cancer Research and Treatment (2007), p. S218.

Huang, M.

Q. Zhu, E. B. Cronin, A. A. Currier, H. S. Vine, M. Huang, N. Chen, and C. Xu, “Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction,” Radiology (Oak Brook, Ill.) 237, 57-66 (2005).
[CrossRef]

Hwang, E.

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

Hylton, N.

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

Intes, X.

S. Nioka, S. Wen, J. Zhang, J. Du, X. Intes, Z. Zhao, and B. Chance, “Simulation study of breast tissue hemodynamics during pressure perturbation,” Adv. Exp. Med. Biol. 566, 17-22 (2005).
[CrossRef]

Jakubowski, D.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39, 6498-6507 (2000).
[CrossRef]

Jakubowski, D. B.

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef]

Jiang, S.

Kauffman, T.

S. A. Carp, T. Kauffman, Q. Fang, E. Rafferty, R. Moore, D. Kopans, and D. Boas, “Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements,” J. Biomed. Opt. 11, 064016 (2006).
[CrossRef]

Klifa, C.

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

Koelliker, S. L.

E. Lazarus, M. B. Mainiero, B. Schepps, S. L. Koelliker, and L. S. Livingston, “BI-RADS lexicon for US and mammography: interobserver variability and positive predictive value,” Radiology (Oak Brook, Ill.) 239, 385-391 (2006).
[CrossRef]

Kogel, C.

Kopans, D.

S. A. Carp, T. Kauffman, Q. Fang, E. Rafferty, R. Moore, D. Kopans, and D. Boas, “Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements,” J. Biomed. Opt. 11, 064016 (2006).
[CrossRef]

Kopans, D. B.

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

Kou, L.

Kukreti, S.

S. Kukreti, A. Cerussi, V. Tanamai, B. Tromberg, M. Rita, H. David, and E. Gratton, “Intrinsic near-infrared spectroscopic biomarkers applied for evaluation of final pathological response to neaoadjuvant chemotherapy,” in Breast Cancer Research and Treatment (2007), p. S250.

Labrie, D.

Lanning, R.

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

Lazarus, E.

E. Lazarus, M. B. Mainiero, B. Schepps, S. L. Koelliker, and L. S. Livingston, “BI-RADS lexicon for US and mammography: interobserver variability and positive predictive value,” Radiology (Oak Brook, Ill.) 239, 385-391 (2006).
[CrossRef]

Lee, J.

J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg, and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27, 757-767 (2006).
[CrossRef]

Li, A.

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

Livingston, L. S.

E. Lazarus, M. B. Mainiero, B. Schepps, S. L. Koelliker, and L. S. Livingston, “BI-RADS lexicon for US and mammography: interobserver variability and positive predictive value,” Radiology (Oak Brook, Ill.) 239, 385-391 (2006).
[CrossRef]

MacAulay, C. E.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, and R. Richards-Kortum, “Design of a multispectral digital colposcope,” in Advanced Biomedical and Clinical Diagnostic Systems V (SPIE, 2007).

MacKinnon, N. B.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, and R. Richards-Kortum, “Design of a multispectral digital colposcope,” in Advanced Biomedical and Clinical Diagnostic Systems V (SPIE, 2007).

Mainiero, M. B.

E. Lazarus, M. B. Mainiero, B. Schepps, S. L. Koelliker, and L. S. Livingston, “BI-RADS lexicon for US and mammography: interobserver variability and positive predictive value,” Radiology (Oak Brook, Ill.) 239, 385-391 (2006).
[CrossRef]

Mao, J. J.

R. X. Xu, D. C. Young, J. J. Mao, and S. P. Povoski, “A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions,” Breast Cancer Res. 9, R88 (2007).
[CrossRef]

Meeks, S. L.

S. L. Meeks, J. M. Buatti, L. G. Bouchet, F. J. Bova, T. C. Ryken, E. C. Pennington, K. M. Anderson, and W. A. Friedman, “Ultrasound-guided extracranial radiosurgery: technique and application,” Int. J. Radiat. Oncol. Biol. Phys. 55, 1092-1101 (2003).
[CrossRef]

Meeuwsen-van der Roest, W. P.

W. G. Zijlstra, A. Buursma, and W. P. Meeuwsen-van der Roest, “Absorption spectra of human fetal and adult oxyhemoglobin, de-oxyhemoglobin, carboxyhemoglobin, and methemoglobin,” Clin. Chem. 37, 1633-1638 (1991).

Mehta, R.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

A. Cerussi, D. Hsiang, N. Shah, M. Compton, R. Mehta, A. F. Durkin, and B. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

W. Tanamai, A. Cerussi, D. Hsiang, R. Mehta, and B. J. Tromberg, “Assessing final pathological response to neoadjuvant chemotherapy using diffuse optical spectroscopy,” in Breast Cancer Research and Treatment (2007), p. S218.

Miller, E. L.

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

Milliken, J.

J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg, and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27, 757-767 (2006).
[CrossRef]

Moore, R.

S. A. Carp, T. Kauffman, Q. Fang, E. Rafferty, R. Moore, D. Kopans, and D. Boas, “Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements,” J. Biomed. Opt. 11, 064016 (2006).
[CrossRef]

Moore, R. H.

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

Nioka, S.

S. Nioka, S. Wen, J. Zhang, J. Du, X. Intes, Z. Zhao, and B. Chance, “Simulation study of breast tissue hemodynamics during pressure perturbation,” Adv. Exp. Med. Biol. 566, 17-22 (2005).
[CrossRef]

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

Orel, S. G.

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

Park, S. Y.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, and R. Richards-Kortum, “Design of a multispectral digital colposcope,” in Advanced Biomedical and Clinical Diagnostic Systems V (SPIE, 2007).

Paulsen, K. D.

Pennington, E. C.

S. L. Meeks, J. M. Buatti, L. G. Bouchet, F. J. Bova, T. C. Ryken, E. C. Pennington, K. M. Anderson, and W. A. Friedman, “Ultrasound-guided extracranial radiosurgery: technique and application,” Int. J. Radiat. Oncol. Biol. Phys. 55, 1092-1101 (2003).
[CrossRef]

Pham, T. H.

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, “Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy,” Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

Pikkula, B. M.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, and R. Richards-Kortum, “Design of a multispectral digital colposcope,” in Advanced Biomedical and Clinical Diagnostic Systems V (SPIE, 2007).

Pogue, B. W.

Poplack, S. P.

Povoski, S. P.

R. X. Xu, D. C. Young, J. J. Mao, and S. P. Povoski, “A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions,” Breast Cancer Res. 9, R88 (2007).
[CrossRef]

Proctor, E.

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

Rafferty, E.

S. A. Carp, T. Kauffman, Q. Fang, E. Rafferty, R. Moore, D. Kopans, and D. Boas, “Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements,” J. Biomed. Opt. 11, 064016 (2006).
[CrossRef]

Richards-Kortum, R.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, and R. Richards-Kortum, “Design of a multispectral digital colposcope,” in Advanced Biomedical and Clinical Diagnostic Systems V (SPIE, 2007).

Rita, M.

S. Kukreti, A. Cerussi, V. Tanamai, B. Tromberg, M. Rita, H. David, and E. Gratton, “Intrinsic near-infrared spectroscopic biomarkers applied for evaluation of final pathological response to neaoadjuvant chemotherapy,” in Breast Cancer Research and Treatment (2007), p. S250.

Ryken, T. C.

S. L. Meeks, J. M. Buatti, L. G. Bouchet, F. J. Bova, T. C. Ryken, E. C. Pennington, K. M. Anderson, and W. A. Friedman, “Ultrasound-guided extracranial radiosurgery: technique and application,” Int. J. Radiat. Oncol. Biol. Phys. 55, 1092-1101 (2003).
[CrossRef]

S., N. Shah

N. Shah S., A. E. Cerussi, D. Gordon, A. Durkin, B. Hill, M. Compton, L. Wenzel, and B. J. Tromberg, “Integration of diffuse optical technology into clinical settings for breast health applications,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), p. SC2.

Saltzman, D. J.

J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg, and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27, 757-767 (2006).
[CrossRef]

Schepps, B.

E. Lazarus, M. B. Mainiero, B. Schepps, S. L. Koelliker, and L. S. Livingston, “BI-RADS lexicon for US and mammography: interobserver variability and positive predictive value,” Radiology (Oak Brook, Ill.) 239, 385-391 (2006).
[CrossRef]

Schnall, M. D.

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

Selb, J.

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

Serachitopol, D.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, and R. Richards-Kortum, “Design of a multispectral digital colposcope,” in Advanced Biomedical and Clinical Diagnostic Systems V (SPIE, 2007).

Shah, N.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

A. Cerussi, D. Hsiang, N. Shah, M. Compton, R. Mehta, A. F. Durkin, and B. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

Tanamai, V.

S. Kukreti, A. Cerussi, V. Tanamai, B. Tromberg, M. Rita, H. David, and E. Gratton, “Intrinsic near-infrared spectroscopic biomarkers applied for evaluation of final pathological response to neaoadjuvant chemotherapy,” in Breast Cancer Research and Treatment (2007), p. S250.

Tanamai, W.

W. Tanamai, A. Cerussi, D. Hsiang, R. Mehta, and B. J. Tromberg, “Assessing final pathological response to neoadjuvant chemotherapy using diffuse optical spectroscopy,” in Breast Cancer Research and Treatment (2007), p. S218.

Tchou, J. C.

Tromberg, B.

A. Cerussi, D. Hsiang, N. Shah, M. Compton, R. Mehta, A. F. Durkin, and B. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

S. Kukreti, A. Cerussi, V. Tanamai, B. Tromberg, M. Rita, H. David, and E. Gratton, “Intrinsic near-infrared spectroscopic biomarkers applied for evaluation of final pathological response to neaoadjuvant chemotherapy,” in Breast Cancer Research and Treatment (2007), p. S250.

Tromberg, B. J.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg, and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27, 757-767 (2006).
[CrossRef]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39, 6498-6507 (2000).
[CrossRef]

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, “Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy,” Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

N. Shah S., A. E. Cerussi, D. Gordon, A. Durkin, B. Hill, M. Compton, L. Wenzel, and B. J. Tromberg, “Integration of diffuse optical technology into clinical settings for breast health applications,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), p. SC2.

W. Tanamai, A. Cerussi, D. Hsiang, R. Mehta, and B. J. Tromberg, “Assessing final pathological response to neoadjuvant chemotherapy using diffuse optical spectroscopy,” in Breast Cancer Research and Treatment (2007), p. S218.

Vine, H. S.

Q. Zhu, E. B. Cronin, A. A. Currier, H. S. Vine, M. Huang, N. Chen, and C. Xu, “Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction,” Radiology (Oak Brook, Ill.) 237, 57-66 (2005).
[CrossRef]

Waddington, T.

J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg, and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27, 757-767 (2006).
[CrossRef]

Watkins, M.

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

Wen, S.

S. Nioka, S. Wen, J. Zhang, J. Du, X. Intes, Z. Zhao, and B. Chance, “Simulation study of breast tissue hemodynamics during pressure perturbation,” Adv. Exp. Med. Biol. 566, 17-22 (2005).
[CrossRef]

Wenzel, L.

N. Shah S., A. E. Cerussi, D. Gordon, A. Durkin, B. Hill, M. Compton, L. Wenzel, and B. J. Tromberg, “Integration of diffuse optical technology into clinical settings for breast health applications,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), p. SC2.

Xu, C.

Q. Zhu, E. B. Cronin, A. A. Currier, H. S. Vine, M. Huang, N. Chen, and C. Xu, “Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction,” Radiology (Oak Brook, Ill.) 237, 57-66 (2005).
[CrossRef]

Xu, R. X.

R. X. Xu, D. C. Young, J. J. Mao, and S. P. Povoski, “A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions,” Breast Cancer Res. 9, R88 (2007).
[CrossRef]

Yodh, A. G.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915-2917 (2005).
[CrossRef]

Young, D. C.

R. X. Xu, D. C. Young, J. J. Mao, and S. P. Povoski, “A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions,” Breast Cancer Res. 9, R88 (2007).
[CrossRef]

Yu, G.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915-2917 (2005).
[CrossRef]

Zhang, J.

S. Nioka, S. Wen, J. Zhang, J. Du, X. Intes, Z. Zhao, and B. Chance, “Simulation study of breast tissue hemodynamics during pressure perturbation,” Adv. Exp. Med. Biol. 566, 17-22 (2005).
[CrossRef]

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

Zhao, Z.

S. Nioka, S. Wen, J. Zhang, J. Du, X. Intes, Z. Zhao, and B. Chance, “Simulation study of breast tissue hemodynamics during pressure perturbation,” Adv. Exp. Med. Biol. 566, 17-22 (2005).
[CrossRef]

Zhou, C.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915-2917 (2005).
[CrossRef]

Zhu, Q.

Q. Zhu, E. B. Cronin, A. A. Currier, H. S. Vine, M. Huang, N. Chen, and C. Xu, “Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction,” Radiology (Oak Brook, Ill.) 237, 57-66 (2005).
[CrossRef]

Zijlstra, W. G.

W. G. Zijlstra, A. Buursma, and W. P. Meeuwsen-van der Roest, “Absorption spectra of human fetal and adult oxyhemoglobin, de-oxyhemoglobin, carboxyhemoglobin, and methemoglobin,” Clin. Chem. 37, 1633-1638 (1991).

Acad. Radiol. (1)

B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. G. Orel, M. D. Schnall, and B. J. Czerniecki, “Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study,” Acad. Radiol. 12, 925-933 (2005).
[CrossRef]

Adv. Exp. Med. Biol. (1)

S. Nioka, S. Wen, J. Zhang, J. Du, X. Intes, Z. Zhao, and B. Chance, “Simulation study of breast tissue hemodynamics during pressure perturbation,” Adv. Exp. Med. Biol. 566, 17-22 (2005).
[CrossRef]

Appl. Opt. (2)

Breast Cancer Res. (1)

R. X. Xu, D. C. Young, J. J. Mao, and S. P. Povoski, “A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions,” Breast Cancer Res. 9, R88 (2007).
[CrossRef]

Clin. Chem. (1)

W. G. Zijlstra, A. Buursma, and W. P. Meeuwsen-van der Roest, “Absorption spectra of human fetal and adult oxyhemoglobin, de-oxyhemoglobin, carboxyhemoglobin, and methemoglobin,” Clin. Chem. 37, 1633-1638 (1991).

Int. J. Radiat. Oncol. Biol. Phys. (1)

S. L. Meeks, J. M. Buatti, L. G. Bouchet, F. J. Bova, T. C. Ryken, E. C. Pennington, K. M. Anderson, and W. A. Friedman, “Ultrasound-guided extracranial radiosurgery: technique and application,” Int. J. Radiat. Oncol. Biol. Phys. 55, 1092-1101 (2003).
[CrossRef]

J. Biomed. Opt. (5)

S. A. Carp, T. Kauffman, Q. Fang, E. Rafferty, R. Moore, D. Kopans, and D. Boas, “Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements,” J. Biomed. Opt. 11, 064016 (2006).
[CrossRef]

A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe, and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60-71 (2002).
[CrossRef]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9, 230-238 (2004).
[CrossRef]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11, 044005 (2006).
[CrossRef]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12, 051903 (2007).
[CrossRef]

J. Ultrasound Med. (1)

H. J. Finberg, “Whither (wither?) the ultrasound specialist?,” J. Ultrasound Med. 23, 1543-1547 (2004).

Opt. Lett. (2)

Phys. Med. Biol. (1)

G. Boverman, Q. Fang, S. A. Carp, E. L. Miller, D. H. Brooks, J. Selb, R. H. Moore, D. B. Kopans, and D. A. Boas, “Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography,” Phys. Med. Biol. 52, 3619-3641 (2007).
[CrossRef]

Physiol. Meas. (1)

J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg, and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27, 757-767 (2006).
[CrossRef]

Proc. Natl. Acad. Sci. U. S. A. (2)

A. Cerussi, D. Hsiang, N. Shah, M. Compton, R. Mehta, A. F. Durkin, and B. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104, 4014-4019 (2007).
[CrossRef]

Radiology (Oak Brook, Ill.) (2)

Q. Zhu, E. B. Cronin, A. A. Currier, H. S. Vine, M. Huang, N. Chen, and C. Xu, “Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction,” Radiology (Oak Brook, Ill.) 237, 57-66 (2005).
[CrossRef]

E. Lazarus, M. B. Mainiero, B. Schepps, S. L. Koelliker, and L. S. Livingston, “BI-RADS lexicon for US and mammography: interobserver variability and positive predictive value,” Radiology (Oak Brook, Ill.) 239, 385-391 (2006).
[CrossRef]

Rev. Sci. Instrum. (1)

T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson, and B. J. Tromberg, “Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy,” Rev. Sci. Instrum. 71, 2500-2513 (2000).
[CrossRef]

Other (6)

N. Shah S., A. E. Cerussi, D. Gordon, A. Durkin, B. Hill, M. Compton, L. Wenzel, and B. J. Tromberg, “Integration of diffuse optical technology into clinical settings for breast health applications,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), p. SC2.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, and R. Richards-Kortum, “Design of a multispectral digital colposcope,” in Advanced Biomedical and Clinical Diagnostic Systems V (SPIE, 2007).

C. Eker, “Optical characterization of tissue for medical diagnostics,” Ph.D. thesis (Lund Institute of Technology, 1999).

W. Tanamai, A. Cerussi, D. Hsiang, R. Mehta, and B. J. Tromberg, “Assessing final pathological response to neoadjuvant chemotherapy using diffuse optical spectroscopy,” in Breast Cancer Research and Treatment (2007), p. S218.

S. Kukreti, A. Cerussi, V. Tanamai, B. Tromberg, M. Rita, H. David, and E. Gratton, “Intrinsic near-infrared spectroscopic biomarkers applied for evaluation of final pathological response to neaoadjuvant chemotherapy,” in Breast Cancer Research and Treatment (2007), p. S250.

C. Klifa, A. Li, J. Hattangadi, N. Shah, J. Gibbs, E. DeMicco, M. Watkins, E. Proctor, A. Cerussi, B. Tromberg, and N. Hylton, “Study of breast tissue composition using magnetic resonance imaging and diffuse optical spectroscopy,” in Biomedical Topical Meeting (BIO) (Optical Society of America, 2006), paper SG4.

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