Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Canine cancer screening via ultraviolet absorbance and fluorescence spectroscopy of serum proteins

Not Accessible

Your library or personal account may give you access

Abstract

A cost-effective optical cancer screening and monitoring technique was demonstrated in a pilot study of canine serum samples and was patented for commercialization. Compared to conventional blood chemistry analysis methods, more accurate estimations of the concentrations of albumin, globulins, and hemoglobin in serum were obtained by fitting the near UV absorbance and photoluminescence spectra of diluted serum as a linear combination of component reference spectra. Tracking these serum proteins over the course of treatment helped to monitor patient immune response to carcinoma and therapy. For cancer screening, 70% of dogs with clinical presentation of cancer displayed suppressed serum hemoglobin levels (below 20mg/dL) in combination with atypical serum protein compositions, that is, albumin levels outside of a safe range (from 4 to 8g/dL) and globulin levels above or below a more normal range (from 1.7 to 3.7g/dL). Of the dogs that met these criteria, only 20% were given a false positive label by this cancer screening test.

© 2007 Optical Society of America

Full Article  |  PDF Article
More Like This
Colorectal cancer detection by gold nanoparticle based surface-enhanced Raman spectroscopy of blood serum and statistical analysis

Duo Lin, Shangyuan Feng, Jianji Pan, Yanping Chen, Juqiang Lin, Guannan Chen, Shusen Xie, Haishan Zeng, and Rong Chen
Opt. Express 19(14) 13565-13577 (2011)

Rapid detection of hysteromyoma and cervical cancer based on serum surface-enhanced Raman spectroscopy and a support vector machine

Xiangxiang Zheng, Guohua Wu, Jing Wang, Longfei Yin, and Xiaoyi Lv
Biomed. Opt. Express 13(4) 1912-1923 (2022)

Prediction of the postoperative prognosis in patients with non-muscle-invasive bladder cancer based on preoperative serum surface-enhanced Raman spectroscopy

Ruochen Zhu, Yuanjun Jiang, Zheng Zhou, Shanshan Zhu, Zhuoyu Zhang, Zhilin Chen, Shuo Chen, and Zhe Zhang
Biomed. Opt. Express 13(8) 4204-4221 (2022)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (14)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Tables (2)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (4)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved