Abstract

The concentration of the main minerals present in human hair is measured on several subjects by Calibration-Free Laser-Induced Breakdown Spectroscopy (CF-LIBS) and compared with the results obtained through a commercial analytical laboratory. The possibility of using CF-LIBS for mineral analysis in hair is discussed, as well as its feasibility for the fast and inexpensive determination of the occurrence of heavy-metal poisoning in hair.

© 2003 Optical Society of America

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References

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  1. D. W. Jenkins, Toxic Trace Metals in Mammalian Hair and Nails, Report 600/4-79-049 (U.S. Environmental Protection Agency, Springfield, Va., 1979).
  2. A. C. Brown, R. G. Crounse, Hair, Trace Elements and Human Illness (Praeger Publications, New York, 1980).
  3. T. H. Maugh, “Hair: a diagnostic tool to complement blood serum and urine,” Science 202, 1271–1273 (1978).
    [CrossRef] [PubMed]
  4. S. Seidel, R. Kreutzer, D. Smith, S. McNeel, D. Gilliss, “Assessment of commercial laboratories performing hair mineral analysis,” J. Amer. Med. Assoc. 285, 67–72 (2001).
    [CrossRef]
  5. S. Barrett, “Commercial hair analysis: science or scam?” J. Amer. Med. Assoc. 254, 1041–1045 (1985).
    [CrossRef]
  6. M. Haruna, M. Ohmi, M. Nakamura, S. Morimoto, “Calcium detection of human hair and nail by the nanosecond time-gated spectroscopy of laser-ablation plume,” in Optical Biopsy III, Proc. SPIE3917, 87–92 (2000).
    [CrossRef]
  7. M. Ohmi, M. Nakamura, S. Morimoto, M. Haruna, “Nanosecond time-gated spectroscopy of laser-ablation plume of human hair to detect calcium for potential diagnoses,” Opt. Rev. 7, 353–357 (2000).
    [CrossRef]
  8. E. L. Surmenko, T. N. Sokolova, V. V. Tuchin, “Microspectral investigation of hair of one girl during six years by laser emission analysis,” in Diagnostic Optical Spectroscopy in Biomedicine, T. G. Papazoglou, G. A. Wagnieres, eds., Proc. SPIE4432, 253–256 (2001).
    [CrossRef]
  9. A. Ciucci, M. Corsi, V. Palleschi, S. Rastelli, A. Salvetti, E. Tognoni, “New procedure for quantitative elemental analysis by laser induced plasma spectroscopy,” Appl. Spectrosc. 53, 960–964 (1999).
    [CrossRef]
  10. D. Bulajic, M. Corsi, G. Cristoforetti, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, “A procedure for correcting self-absorption in calibration free-laser induced breakdown spectroscopy,” Spectrochim. Acta Part B 57, 339–353 (2002).
    [CrossRef]

2002

D. Bulajic, M. Corsi, G. Cristoforetti, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, “A procedure for correcting self-absorption in calibration free-laser induced breakdown spectroscopy,” Spectrochim. Acta Part B 57, 339–353 (2002).
[CrossRef]

2001

S. Seidel, R. Kreutzer, D. Smith, S. McNeel, D. Gilliss, “Assessment of commercial laboratories performing hair mineral analysis,” J. Amer. Med. Assoc. 285, 67–72 (2001).
[CrossRef]

2000

M. Ohmi, M. Nakamura, S. Morimoto, M. Haruna, “Nanosecond time-gated spectroscopy of laser-ablation plume of human hair to detect calcium for potential diagnoses,” Opt. Rev. 7, 353–357 (2000).
[CrossRef]

1999

1985

S. Barrett, “Commercial hair analysis: science or scam?” J. Amer. Med. Assoc. 254, 1041–1045 (1985).
[CrossRef]

1978

T. H. Maugh, “Hair: a diagnostic tool to complement blood serum and urine,” Science 202, 1271–1273 (1978).
[CrossRef] [PubMed]

Barrett, S.

S. Barrett, “Commercial hair analysis: science or scam?” J. Amer. Med. Assoc. 254, 1041–1045 (1985).
[CrossRef]

Brown, A. C.

A. C. Brown, R. G. Crounse, Hair, Trace Elements and Human Illness (Praeger Publications, New York, 1980).

Bulajic, D.

D. Bulajic, M. Corsi, G. Cristoforetti, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, “A procedure for correcting self-absorption in calibration free-laser induced breakdown spectroscopy,” Spectrochim. Acta Part B 57, 339–353 (2002).
[CrossRef]

Ciucci, A.

Corsi, M.

D. Bulajic, M. Corsi, G. Cristoforetti, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, “A procedure for correcting self-absorption in calibration free-laser induced breakdown spectroscopy,” Spectrochim. Acta Part B 57, 339–353 (2002).
[CrossRef]

A. Ciucci, M. Corsi, V. Palleschi, S. Rastelli, A. Salvetti, E. Tognoni, “New procedure for quantitative elemental analysis by laser induced plasma spectroscopy,” Appl. Spectrosc. 53, 960–964 (1999).
[CrossRef]

Cristoforetti, G.

D. Bulajic, M. Corsi, G. Cristoforetti, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, “A procedure for correcting self-absorption in calibration free-laser induced breakdown spectroscopy,” Spectrochim. Acta Part B 57, 339–353 (2002).
[CrossRef]

Crounse, R. G.

A. C. Brown, R. G. Crounse, Hair, Trace Elements and Human Illness (Praeger Publications, New York, 1980).

Gilliss, D.

S. Seidel, R. Kreutzer, D. Smith, S. McNeel, D. Gilliss, “Assessment of commercial laboratories performing hair mineral analysis,” J. Amer. Med. Assoc. 285, 67–72 (2001).
[CrossRef]

Haruna, M.

M. Ohmi, M. Nakamura, S. Morimoto, M. Haruna, “Nanosecond time-gated spectroscopy of laser-ablation plume of human hair to detect calcium for potential diagnoses,” Opt. Rev. 7, 353–357 (2000).
[CrossRef]

M. Haruna, M. Ohmi, M. Nakamura, S. Morimoto, “Calcium detection of human hair and nail by the nanosecond time-gated spectroscopy of laser-ablation plume,” in Optical Biopsy III, Proc. SPIE3917, 87–92 (2000).
[CrossRef]

Jenkins, D. W.

D. W. Jenkins, Toxic Trace Metals in Mammalian Hair and Nails, Report 600/4-79-049 (U.S. Environmental Protection Agency, Springfield, Va., 1979).

Kreutzer, R.

S. Seidel, R. Kreutzer, D. Smith, S. McNeel, D. Gilliss, “Assessment of commercial laboratories performing hair mineral analysis,” J. Amer. Med. Assoc. 285, 67–72 (2001).
[CrossRef]

Legnaioli, S.

D. Bulajic, M. Corsi, G. Cristoforetti, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, “A procedure for correcting self-absorption in calibration free-laser induced breakdown spectroscopy,” Spectrochim. Acta Part B 57, 339–353 (2002).
[CrossRef]

Maugh, T. H.

T. H. Maugh, “Hair: a diagnostic tool to complement blood serum and urine,” Science 202, 1271–1273 (1978).
[CrossRef] [PubMed]

McNeel, S.

S. Seidel, R. Kreutzer, D. Smith, S. McNeel, D. Gilliss, “Assessment of commercial laboratories performing hair mineral analysis,” J. Amer. Med. Assoc. 285, 67–72 (2001).
[CrossRef]

Morimoto, S.

M. Ohmi, M. Nakamura, S. Morimoto, M. Haruna, “Nanosecond time-gated spectroscopy of laser-ablation plume of human hair to detect calcium for potential diagnoses,” Opt. Rev. 7, 353–357 (2000).
[CrossRef]

M. Haruna, M. Ohmi, M. Nakamura, S. Morimoto, “Calcium detection of human hair and nail by the nanosecond time-gated spectroscopy of laser-ablation plume,” in Optical Biopsy III, Proc. SPIE3917, 87–92 (2000).
[CrossRef]

Nakamura, M.

M. Ohmi, M. Nakamura, S. Morimoto, M. Haruna, “Nanosecond time-gated spectroscopy of laser-ablation plume of human hair to detect calcium for potential diagnoses,” Opt. Rev. 7, 353–357 (2000).
[CrossRef]

M. Haruna, M. Ohmi, M. Nakamura, S. Morimoto, “Calcium detection of human hair and nail by the nanosecond time-gated spectroscopy of laser-ablation plume,” in Optical Biopsy III, Proc. SPIE3917, 87–92 (2000).
[CrossRef]

Ohmi, M.

M. Ohmi, M. Nakamura, S. Morimoto, M. Haruna, “Nanosecond time-gated spectroscopy of laser-ablation plume of human hair to detect calcium for potential diagnoses,” Opt. Rev. 7, 353–357 (2000).
[CrossRef]

M. Haruna, M. Ohmi, M. Nakamura, S. Morimoto, “Calcium detection of human hair and nail by the nanosecond time-gated spectroscopy of laser-ablation plume,” in Optical Biopsy III, Proc. SPIE3917, 87–92 (2000).
[CrossRef]

Palleschi, V.

D. Bulajic, M. Corsi, G. Cristoforetti, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, “A procedure for correcting self-absorption in calibration free-laser induced breakdown spectroscopy,” Spectrochim. Acta Part B 57, 339–353 (2002).
[CrossRef]

A. Ciucci, M. Corsi, V. Palleschi, S. Rastelli, A. Salvetti, E. Tognoni, “New procedure for quantitative elemental analysis by laser induced plasma spectroscopy,” Appl. Spectrosc. 53, 960–964 (1999).
[CrossRef]

Rastelli, S.

Salvetti, A.

D. Bulajic, M. Corsi, G. Cristoforetti, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, “A procedure for correcting self-absorption in calibration free-laser induced breakdown spectroscopy,” Spectrochim. Acta Part B 57, 339–353 (2002).
[CrossRef]

A. Ciucci, M. Corsi, V. Palleschi, S. Rastelli, A. Salvetti, E. Tognoni, “New procedure for quantitative elemental analysis by laser induced plasma spectroscopy,” Appl. Spectrosc. 53, 960–964 (1999).
[CrossRef]

Seidel, S.

S. Seidel, R. Kreutzer, D. Smith, S. McNeel, D. Gilliss, “Assessment of commercial laboratories performing hair mineral analysis,” J. Amer. Med. Assoc. 285, 67–72 (2001).
[CrossRef]

Smith, D.

S. Seidel, R. Kreutzer, D. Smith, S. McNeel, D. Gilliss, “Assessment of commercial laboratories performing hair mineral analysis,” J. Amer. Med. Assoc. 285, 67–72 (2001).
[CrossRef]

Sokolova, T. N.

E. L. Surmenko, T. N. Sokolova, V. V. Tuchin, “Microspectral investigation of hair of one girl during six years by laser emission analysis,” in Diagnostic Optical Spectroscopy in Biomedicine, T. G. Papazoglou, G. A. Wagnieres, eds., Proc. SPIE4432, 253–256 (2001).
[CrossRef]

Surmenko, E. L.

E. L. Surmenko, T. N. Sokolova, V. V. Tuchin, “Microspectral investigation of hair of one girl during six years by laser emission analysis,” in Diagnostic Optical Spectroscopy in Biomedicine, T. G. Papazoglou, G. A. Wagnieres, eds., Proc. SPIE4432, 253–256 (2001).
[CrossRef]

Tognoni, E.

D. Bulajic, M. Corsi, G. Cristoforetti, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, “A procedure for correcting self-absorption in calibration free-laser induced breakdown spectroscopy,” Spectrochim. Acta Part B 57, 339–353 (2002).
[CrossRef]

A. Ciucci, M. Corsi, V. Palleschi, S. Rastelli, A. Salvetti, E. Tognoni, “New procedure for quantitative elemental analysis by laser induced plasma spectroscopy,” Appl. Spectrosc. 53, 960–964 (1999).
[CrossRef]

Tuchin, V. V.

E. L. Surmenko, T. N. Sokolova, V. V. Tuchin, “Microspectral investigation of hair of one girl during six years by laser emission analysis,” in Diagnostic Optical Spectroscopy in Biomedicine, T. G. Papazoglou, G. A. Wagnieres, eds., Proc. SPIE4432, 253–256 (2001).
[CrossRef]

Appl. Spectrosc.

J. Amer. Med. Assoc.

S. Seidel, R. Kreutzer, D. Smith, S. McNeel, D. Gilliss, “Assessment of commercial laboratories performing hair mineral analysis,” J. Amer. Med. Assoc. 285, 67–72 (2001).
[CrossRef]

S. Barrett, “Commercial hair analysis: science or scam?” J. Amer. Med. Assoc. 254, 1041–1045 (1985).
[CrossRef]

Opt. Rev.

M. Ohmi, M. Nakamura, S. Morimoto, M. Haruna, “Nanosecond time-gated spectroscopy of laser-ablation plume of human hair to detect calcium for potential diagnoses,” Opt. Rev. 7, 353–357 (2000).
[CrossRef]

Science

T. H. Maugh, “Hair: a diagnostic tool to complement blood serum and urine,” Science 202, 1271–1273 (1978).
[CrossRef] [PubMed]

Spectrochim. Acta Part B

D. Bulajic, M. Corsi, G. Cristoforetti, S. Legnaioli, V. Palleschi, A. Salvetti, E. Tognoni, “A procedure for correcting self-absorption in calibration free-laser induced breakdown spectroscopy,” Spectrochim. Acta Part B 57, 339–353 (2002).
[CrossRef]

Other

E. L. Surmenko, T. N. Sokolova, V. V. Tuchin, “Microspectral investigation of hair of one girl during six years by laser emission analysis,” in Diagnostic Optical Spectroscopy in Biomedicine, T. G. Papazoglou, G. A. Wagnieres, eds., Proc. SPIE4432, 253–256 (2001).
[CrossRef]

M. Haruna, M. Ohmi, M. Nakamura, S. Morimoto, “Calcium detection of human hair and nail by the nanosecond time-gated spectroscopy of laser-ablation plume,” in Optical Biopsy III, Proc. SPIE3917, 87–92 (2000).
[CrossRef]

D. W. Jenkins, Toxic Trace Metals in Mammalian Hair and Nails, Report 600/4-79-049 (U.S. Environmental Protection Agency, Springfield, Va., 1979).

A. C. Brown, R. G. Crounse, Hair, Trace Elements and Human Illness (Praeger Publications, New York, 1980).

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Figures (6)

Fig. 1
Fig. 1

Experimental LIBS setup used for hair tissue mineral analysis.

Fig. 2
Fig. 2

LIBS spectrum corresponding to the hair sample from subject a analyzed in this work. The arrows indicate the spectral lines used for CF-LIBS quantitative analysis.

Fig. 3
Fig. 3

Average values of plasma temperature and electron density for different categories of hair color.

Fig. 4
Fig. 4

Comparison of absolute elemental concentration of various elements among the eleven subjects of this work (Mg, K, Ca, and Na). The concentrations are expressed in mg/% [mg per 100 grams, 1 mg/% = 10 parts per million (ppm) in weight].

Fig. 5
Fig. 5

Comparison of absolute aluminium concentration for the eleven subjects of this work. Al concentration is expressed in mg/% (mg per 100 grams, 1 mg/% = 10 ppm in weight).

Fig. 6
Fig. 6

(a) Comparison of CF-LIBS-determined Na/K ratio for the eleven subjects of this work. The arrow indicates the Na/K ratio measured by the commercial laboratory for Subject a. (b) Comparison of CF-LIBS-determined Na/Mg ratio for the eleven subjects of this work. The arrow indicates the Na/Mg ratio measured by the commercial laboratory for Subject a.

Tables (1)

Tables Icon

Table 1 List of Subjects Gender, Age, and Hair Color

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