Abstract

We present a noninvasive full-field method—laser speckle imaging (LSI)—for measuring the regional mesenteric blood flow without scanning. A system of LSI was designed and validated in a model experiment. Dynamics of regional blood flow in the rat mesentery under the influence of noradrenaline were monitored by this method. Spatial and temporal characteristics of the mesenteric blood-flow response were achieved with high resolution. These suggested that LSI might provide a new approach to microcirculation studies.

© 2003 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
    [CrossRef]
  2. K. Mithofer, J. Schmidt, M. M. Gebhard, H. J. Buhr, C. Herfarth, E. Klar, “Measurement of blood flow in pancreatic exchange capillaries with FITC-labeled erythrocytes,” Microvasc. Res. 49, 33–36 (1995).
    [CrossRef] [PubMed]
  3. S. Atsushi, T. Shunji, H. Keitaro, “Pharmacological evaluation of a new laser blood flowmeter for measuring coronary blood flow, assessed in the canine isolated, blood-perfused ventricular tissue preparation in comparison with an electromagnetic flowmeter,” Jpn. J. Pharmacol. 80, 263–266 (1999).
    [CrossRef]
  4. M. D. Stern, “Laser Doppler velocimetry in blood and multiply scattering fluids: theory,” Appl. Opt. 24, 1968–1986 (1985).
    [CrossRef] [PubMed]
  5. E. I. Galanzha, G. E. Brill, Y. Aizu, S. S. Ulynov, V. V. Tuchin, “Speckle and Doppler methods of blood and lymph flow monitoring,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 881–937.
  6. H. Fujii, T. Asakura, K. Nohira, Y. Shintomi, T. Ohura, “Blood flow observed by time-varying laser speckle,” Opt. Lett. 10, 104–106 (1985).
    [CrossRef] [PubMed]
  7. D. A. Zimnyakov, J. D. Briers, V. V. Tuchin, “Speckle technologies for monitoring and imaging of tissues and tissuelike phantoms,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 987–1036.
  8. B. M. Ances, J. H. Greenberg, J. A. Detre, “Laser Doppler imaging of activation-flow coupling in the rat somatosensory cortex,” NeuroImage 10, 716–723 (1999).
    [CrossRef] [PubMed]
  9. A. F. Fercher, J. D. Briers, “Flow visualization by means of single-exposure speckle photography,” Opt. Commun. 37, 326–329 (1981).
    [CrossRef]
  10. J. D. Briers, S. Webster, “Laser speckle contrast analysis (LASCA): A nonscanning, full-field technique for monitoring capillary blood flow,” J. Biomed. Opt. 1, 174–179 (1996).
    [CrossRef] [PubMed]
  11. B. Ruth, “Measuring the steady-state value and the dynamics of the skin blood flow using the non-contact laser speckle method,” Med. Eng. Phys. 16, 105–111 (1994).
    [CrossRef] [PubMed]
  12. K. Yaoeda, M. Shirakashi, S. Funaki, H. Funaki, T. Nakatsue, H. Abe, “Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry,” Am. J. Ophthalmol. 129, 734–739 (2000).
    [CrossRef] [PubMed]
  13. H. Bolay, U. Reuter, A. K. Dunn, Z. Huang, D. A. Boas, A. M. Moskowitz, “Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model,” Nat. Med. 8, 136–142 (2002).
    [CrossRef] [PubMed]
  14. H. Y. Cheng, Q. M. Luo, S. Q. Zeng, L. Yao, A. J. Wang, S. S. Ul’yanov, “The application of zero-crossings of laser speckle for real-time monitoring of velocity of lymph flow,” Space Med. Med. Eng. 14, 187–191 (2001) (in Chinese).
  15. H. Y. Cheng, Q. M. Luo, Z. Wang, L. Yao, S. S. Ul’yanov, E. I. Ekateryna, S. Q. Zeng, “Application of laser speckle interferometry for monitoring the dynamics of lymph flow,” in International Workshop on Photonics and Imaging in Biology and Medicine, Q. M. Luo, B. Chance, V. V. Tuchin, eds., Proc. SPIE4536, 130–136 (2001).
    [CrossRef]
  16. H. Y. Cheng, D. Zhu, Q. M. Luo, S. Q. Zeng, Z. Wang, S. S. Ul’yanov, “Optical monitoring of the dynamic change of blood perfusion,” Chin. J. Lasers 30, 668–705 (2003) (in Chinese).
  17. A. K. Dunn, H. Bolay, M. A. Moskowitz, D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21, 195–201 (2001).
    [CrossRef] [PubMed]
  18. S. J. Kirkpatrick, D. D. Duncan, “Optical assessment of tissue mechanics,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 1037–1084.
  19. J. W. Goodman, “Some effects of target-induced scintillation on optical radar performance,” Proc. IEEE 53, 1688–1700 (1965).
    [CrossRef]
  20. R. Bonner, R. Nossal, “Model for laser Doppler measurements of blood flow in tissue,” Appl. Opt. 20, 2097–2107 (1981).
    [CrossRef] [PubMed]
  21. R. Scalia, T. Murohara, B. Campbell, A. Kaji, A. M. Lefer, “Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature,” Am. J. Physiol. 272, H2584–H2590 (1997).
    [PubMed]
  22. J. D. Briers, G. Richarda, X. W. He, “Capillary blood flow monitoring using laser speckle contrast analysis (LASCA),” J. Biomed. Opt. 4, 164–175 (1999).
    [CrossRef] [PubMed]
  23. S. S. Ul’Yanov, D. A. Zimnyakov, V. V. Tuchin, “Fundamentals and applications of dynamic speckles induced by focused laser beam scattering,” Opt. Eng. 33, 3189–3201 (1994).
    [CrossRef]
  24. V. V. Tuchin, “Coherent optical techniques for the analysis of tissue structure and dynamics,” J. Biomed. Opt. 4, 106–124 (1999).
    [CrossRef] [PubMed]
  25. L. Tian, Methodology of Microcirculation (Atomic Energy, Beijing, 1993).
  26. D. N. Granger, P. D. Richardson, P. R. Kvietys, N. A. Mortillaro, “Intestinal blood flow,” Gastroenterology 78, 837–863 (1980).
    [PubMed]
  27. J. D. Briers, “Laser Doppler and time-varying speckle: a reconciliation,” J. Opt. Soc. Am. 13, 345–350 (1996).
    [CrossRef]
  28. E. I. Galanzha, I. V. Fedosov, A. V. Solov’eva, T. V. Stepanova, V. V. Tuchin, G. E. Brill, “In vivo lymph dynamic monitoring using speckle-correlation technique and light microscopy,” in Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, A. V. Priezzhev, G. L. Cote, eds., Proc. SPIE4624, 130–133 (2002).
  29. H. Gebhard, S. P. Zysk, H. J. Refior, W. Plitz, K. Messmer, A. Veihelmann, “A new method to investigate inflammatory responses to wear particles in vivo,” J. Vasc. Res. 39, S1 (2002).
  30. C. M. Moser, T. Mempel, J. Hutter, W. M. Kuebler, F. Krombach, “A novel method for the intravital microscopic analysis of leukocyte transendothelial migration,” J. Vasc. Res. 39, 42–50 (2002).

2003 (1)

H. Y. Cheng, D. Zhu, Q. M. Luo, S. Q. Zeng, Z. Wang, S. S. Ul’yanov, “Optical monitoring of the dynamic change of blood perfusion,” Chin. J. Lasers 30, 668–705 (2003) (in Chinese).

2002 (3)

H. Bolay, U. Reuter, A. K. Dunn, Z. Huang, D. A. Boas, A. M. Moskowitz, “Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model,” Nat. Med. 8, 136–142 (2002).
[CrossRef] [PubMed]

H. Gebhard, S. P. Zysk, H. J. Refior, W. Plitz, K. Messmer, A. Veihelmann, “A new method to investigate inflammatory responses to wear particles in vivo,” J. Vasc. Res. 39, S1 (2002).

C. M. Moser, T. Mempel, J. Hutter, W. M. Kuebler, F. Krombach, “A novel method for the intravital microscopic analysis of leukocyte transendothelial migration,” J. Vasc. Res. 39, 42–50 (2002).

2001 (2)

H. Y. Cheng, Q. M. Luo, S. Q. Zeng, L. Yao, A. J. Wang, S. S. Ul’yanov, “The application of zero-crossings of laser speckle for real-time monitoring of velocity of lymph flow,” Space Med. Med. Eng. 14, 187–191 (2001) (in Chinese).

A. K. Dunn, H. Bolay, M. A. Moskowitz, D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21, 195–201 (2001).
[CrossRef] [PubMed]

2000 (2)

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

K. Yaoeda, M. Shirakashi, S. Funaki, H. Funaki, T. Nakatsue, H. Abe, “Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry,” Am. J. Ophthalmol. 129, 734–739 (2000).
[CrossRef] [PubMed]

1999 (4)

J. D. Briers, G. Richarda, X. W. He, “Capillary blood flow monitoring using laser speckle contrast analysis (LASCA),” J. Biomed. Opt. 4, 164–175 (1999).
[CrossRef] [PubMed]

B. M. Ances, J. H. Greenberg, J. A. Detre, “Laser Doppler imaging of activation-flow coupling in the rat somatosensory cortex,” NeuroImage 10, 716–723 (1999).
[CrossRef] [PubMed]

V. V. Tuchin, “Coherent optical techniques for the analysis of tissue structure and dynamics,” J. Biomed. Opt. 4, 106–124 (1999).
[CrossRef] [PubMed]

S. Atsushi, T. Shunji, H. Keitaro, “Pharmacological evaluation of a new laser blood flowmeter for measuring coronary blood flow, assessed in the canine isolated, blood-perfused ventricular tissue preparation in comparison with an electromagnetic flowmeter,” Jpn. J. Pharmacol. 80, 263–266 (1999).
[CrossRef]

1997 (1)

R. Scalia, T. Murohara, B. Campbell, A. Kaji, A. M. Lefer, “Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature,” Am. J. Physiol. 272, H2584–H2590 (1997).
[PubMed]

1996 (2)

J. D. Briers, S. Webster, “Laser speckle contrast analysis (LASCA): A nonscanning, full-field technique for monitoring capillary blood flow,” J. Biomed. Opt. 1, 174–179 (1996).
[CrossRef] [PubMed]

J. D. Briers, “Laser Doppler and time-varying speckle: a reconciliation,” J. Opt. Soc. Am. 13, 345–350 (1996).
[CrossRef]

1995 (1)

K. Mithofer, J. Schmidt, M. M. Gebhard, H. J. Buhr, C. Herfarth, E. Klar, “Measurement of blood flow in pancreatic exchange capillaries with FITC-labeled erythrocytes,” Microvasc. Res. 49, 33–36 (1995).
[CrossRef] [PubMed]

1994 (2)

S. S. Ul’Yanov, D. A. Zimnyakov, V. V. Tuchin, “Fundamentals and applications of dynamic speckles induced by focused laser beam scattering,” Opt. Eng. 33, 3189–3201 (1994).
[CrossRef]

B. Ruth, “Measuring the steady-state value and the dynamics of the skin blood flow using the non-contact laser speckle method,” Med. Eng. Phys. 16, 105–111 (1994).
[CrossRef] [PubMed]

1985 (2)

1981 (2)

R. Bonner, R. Nossal, “Model for laser Doppler measurements of blood flow in tissue,” Appl. Opt. 20, 2097–2107 (1981).
[CrossRef] [PubMed]

A. F. Fercher, J. D. Briers, “Flow visualization by means of single-exposure speckle photography,” Opt. Commun. 37, 326–329 (1981).
[CrossRef]

1980 (1)

D. N. Granger, P. D. Richardson, P. R. Kvietys, N. A. Mortillaro, “Intestinal blood flow,” Gastroenterology 78, 837–863 (1980).
[PubMed]

1965 (1)

J. W. Goodman, “Some effects of target-induced scintillation on optical radar performance,” Proc. IEEE 53, 1688–1700 (1965).
[CrossRef]

Abe, H.

K. Yaoeda, M. Shirakashi, S. Funaki, H. Funaki, T. Nakatsue, H. Abe, “Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry,” Am. J. Ophthalmol. 129, 734–739 (2000).
[CrossRef] [PubMed]

Aizu, Y.

E. I. Galanzha, G. E. Brill, Y. Aizu, S. S. Ulynov, V. V. Tuchin, “Speckle and Doppler methods of blood and lymph flow monitoring,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 881–937.

Ances, B. M.

B. M. Ances, J. H. Greenberg, J. A. Detre, “Laser Doppler imaging of activation-flow coupling in the rat somatosensory cortex,” NeuroImage 10, 716–723 (1999).
[CrossRef] [PubMed]

Asakura, T.

Atsushi, S.

S. Atsushi, T. Shunji, H. Keitaro, “Pharmacological evaluation of a new laser blood flowmeter for measuring coronary blood flow, assessed in the canine isolated, blood-perfused ventricular tissue preparation in comparison with an electromagnetic flowmeter,” Jpn. J. Pharmacol. 80, 263–266 (1999).
[CrossRef]

Axel, H.

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

Boas, D. A.

H. Bolay, U. Reuter, A. K. Dunn, Z. Huang, D. A. Boas, A. M. Moskowitz, “Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model,” Nat. Med. 8, 136–142 (2002).
[CrossRef] [PubMed]

A. K. Dunn, H. Bolay, M. A. Moskowitz, D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21, 195–201 (2001).
[CrossRef] [PubMed]

Bolay, H.

H. Bolay, U. Reuter, A. K. Dunn, Z. Huang, D. A. Boas, A. M. Moskowitz, “Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model,” Nat. Med. 8, 136–142 (2002).
[CrossRef] [PubMed]

A. K. Dunn, H. Bolay, M. A. Moskowitz, D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21, 195–201 (2001).
[CrossRef] [PubMed]

Bonner, R.

Briers, J. D.

J. D. Briers, G. Richarda, X. W. He, “Capillary blood flow monitoring using laser speckle contrast analysis (LASCA),” J. Biomed. Opt. 4, 164–175 (1999).
[CrossRef] [PubMed]

J. D. Briers, “Laser Doppler and time-varying speckle: a reconciliation,” J. Opt. Soc. Am. 13, 345–350 (1996).
[CrossRef]

J. D. Briers, S. Webster, “Laser speckle contrast analysis (LASCA): A nonscanning, full-field technique for monitoring capillary blood flow,” J. Biomed. Opt. 1, 174–179 (1996).
[CrossRef] [PubMed]

A. F. Fercher, J. D. Briers, “Flow visualization by means of single-exposure speckle photography,” Opt. Commun. 37, 326–329 (1981).
[CrossRef]

D. A. Zimnyakov, J. D. Briers, V. V. Tuchin, “Speckle technologies for monitoring and imaging of tissues and tissuelike phantoms,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 987–1036.

Brill, G. E.

E. I. Galanzha, I. V. Fedosov, A. V. Solov’eva, T. V. Stepanova, V. V. Tuchin, G. E. Brill, “In vivo lymph dynamic monitoring using speckle-correlation technique and light microscopy,” in Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, A. V. Priezzhev, G. L. Cote, eds., Proc. SPIE4624, 130–133 (2002).

E. I. Galanzha, G. E. Brill, Y. Aizu, S. S. Ulynov, V. V. Tuchin, “Speckle and Doppler methods of blood and lymph flow monitoring,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 881–937.

Buhr, H. J.

K. Mithofer, J. Schmidt, M. M. Gebhard, H. J. Buhr, C. Herfarth, E. Klar, “Measurement of blood flow in pancreatic exchange capillaries with FITC-labeled erythrocytes,” Microvasc. Res. 49, 33–36 (1995).
[CrossRef] [PubMed]

Campbell, B.

R. Scalia, T. Murohara, B. Campbell, A. Kaji, A. M. Lefer, “Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature,” Am. J. Physiol. 272, H2584–H2590 (1997).
[PubMed]

Cheng, H. Y.

H. Y. Cheng, D. Zhu, Q. M. Luo, S. Q. Zeng, Z. Wang, S. S. Ul’yanov, “Optical monitoring of the dynamic change of blood perfusion,” Chin. J. Lasers 30, 668–705 (2003) (in Chinese).

H. Y. Cheng, Q. M. Luo, S. Q. Zeng, L. Yao, A. J. Wang, S. S. Ul’yanov, “The application of zero-crossings of laser speckle for real-time monitoring of velocity of lymph flow,” Space Med. Med. Eng. 14, 187–191 (2001) (in Chinese).

H. Y. Cheng, Q. M. Luo, Z. Wang, L. Yao, S. S. Ul’yanov, E. I. Ekateryna, S. Q. Zeng, “Application of laser speckle interferometry for monitoring the dynamics of lymph flow,” in International Workshop on Photonics and Imaging in Biology and Medicine, Q. M. Luo, B. Chance, V. V. Tuchin, eds., Proc. SPIE4536, 130–136 (2001).
[CrossRef]

Detre, J. A.

B. M. Ances, J. H. Greenberg, J. A. Detre, “Laser Doppler imaging of activation-flow coupling in the rat somatosensory cortex,” NeuroImage 10, 716–723 (1999).
[CrossRef] [PubMed]

Duncan, D. D.

S. J. Kirkpatrick, D. D. Duncan, “Optical assessment of tissue mechanics,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 1037–1084.

Dunn, A. K.

H. Bolay, U. Reuter, A. K. Dunn, Z. Huang, D. A. Boas, A. M. Moskowitz, “Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model,” Nat. Med. 8, 136–142 (2002).
[CrossRef] [PubMed]

A. K. Dunn, H. Bolay, M. A. Moskowitz, D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21, 195–201 (2001).
[CrossRef] [PubMed]

Ekateryna, E. I.

H. Y. Cheng, Q. M. Luo, Z. Wang, L. Yao, S. S. Ul’yanov, E. I. Ekateryna, S. Q. Zeng, “Application of laser speckle interferometry for monitoring the dynamics of lymph flow,” in International Workshop on Photonics and Imaging in Biology and Medicine, Q. M. Luo, B. Chance, V. V. Tuchin, eds., Proc. SPIE4536, 130–136 (2001).
[CrossRef]

Fedosov, I. V.

E. I. Galanzha, I. V. Fedosov, A. V. Solov’eva, T. V. Stepanova, V. V. Tuchin, G. E. Brill, “In vivo lymph dynamic monitoring using speckle-correlation technique and light microscopy,” in Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, A. V. Priezzhev, G. L. Cote, eds., Proc. SPIE4624, 130–133 (2002).

Fercher, A. F.

A. F. Fercher, J. D. Briers, “Flow visualization by means of single-exposure speckle photography,” Opt. Commun. 37, 326–329 (1981).
[CrossRef]

Fujii, H.

Funaki, H.

K. Yaoeda, M. Shirakashi, S. Funaki, H. Funaki, T. Nakatsue, H. Abe, “Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry,” Am. J. Ophthalmol. 129, 734–739 (2000).
[CrossRef] [PubMed]

Funaki, S.

K. Yaoeda, M. Shirakashi, S. Funaki, H. Funaki, T. Nakatsue, H. Abe, “Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry,” Am. J. Ophthalmol. 129, 734–739 (2000).
[CrossRef] [PubMed]

Galanzha, E. I.

E. I. Galanzha, G. E. Brill, Y. Aizu, S. S. Ulynov, V. V. Tuchin, “Speckle and Doppler methods of blood and lymph flow monitoring,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 881–937.

E. I. Galanzha, I. V. Fedosov, A. V. Solov’eva, T. V. Stepanova, V. V. Tuchin, G. E. Brill, “In vivo lymph dynamic monitoring using speckle-correlation technique and light microscopy,” in Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, A. V. Priezzhev, G. L. Cote, eds., Proc. SPIE4624, 130–133 (2002).

Gebhard, H.

H. Gebhard, S. P. Zysk, H. J. Refior, W. Plitz, K. Messmer, A. Veihelmann, “A new method to investigate inflammatory responses to wear particles in vivo,” J. Vasc. Res. 39, S1 (2002).

Gebhard, M. M.

K. Mithofer, J. Schmidt, M. M. Gebhard, H. J. Buhr, C. Herfarth, E. Klar, “Measurement of blood flow in pancreatic exchange capillaries with FITC-labeled erythrocytes,” Microvasc. Res. 49, 33–36 (1995).
[CrossRef] [PubMed]

Georg, H.

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

Goodman, J. W.

J. W. Goodman, “Some effects of target-induced scintillation on optical radar performance,” Proc. IEEE 53, 1688–1700 (1965).
[CrossRef]

Granger, D. N.

D. N. Granger, P. D. Richardson, P. R. Kvietys, N. A. Mortillaro, “Intestinal blood flow,” Gastroenterology 78, 837–863 (1980).
[PubMed]

Greenberg, J. H.

B. M. Ances, J. H. Greenberg, J. A. Detre, “Laser Doppler imaging of activation-flow coupling in the rat somatosensory cortex,” NeuroImage 10, 716–723 (1999).
[CrossRef] [PubMed]

Hans-Anton, L.

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

He, X. W.

J. D. Briers, G. Richarda, X. W. He, “Capillary blood flow monitoring using laser speckle contrast analysis (LASCA),” J. Biomed. Opt. 4, 164–175 (1999).
[CrossRef] [PubMed]

Herfarth, C.

K. Mithofer, J. Schmidt, M. M. Gebhard, H. J. Buhr, C. Herfarth, E. Klar, “Measurement of blood flow in pancreatic exchange capillaries with FITC-labeled erythrocytes,” Microvasc. Res. 49, 33–36 (1995).
[CrossRef] [PubMed]

Huang, Z.

H. Bolay, U. Reuter, A. K. Dunn, Z. Huang, D. A. Boas, A. M. Moskowitz, “Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model,” Nat. Med. 8, 136–142 (2002).
[CrossRef] [PubMed]

Hutter, J.

C. M. Moser, T. Mempel, J. Hutter, W. M. Kuebler, F. Krombach, “A novel method for the intravital microscopic analysis of leukocyte transendothelial migration,” J. Vasc. Res. 39, 42–50 (2002).

Jürgen, M.

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

Kaji, A.

R. Scalia, T. Murohara, B. Campbell, A. Kaji, A. M. Lefer, “Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature,” Am. J. Physiol. 272, H2584–H2590 (1997).
[PubMed]

Keitaro, H.

S. Atsushi, T. Shunji, H. Keitaro, “Pharmacological evaluation of a new laser blood flowmeter for measuring coronary blood flow, assessed in the canine isolated, blood-perfused ventricular tissue preparation in comparison with an electromagnetic flowmeter,” Jpn. J. Pharmacol. 80, 263–266 (1999).
[CrossRef]

Kirkpatrick, S. J.

S. J. Kirkpatrick, D. D. Duncan, “Optical assessment of tissue mechanics,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 1037–1084.

Klar, E.

K. Mithofer, J. Schmidt, M. M. Gebhard, H. J. Buhr, C. Herfarth, E. Klar, “Measurement of blood flow in pancreatic exchange capillaries with FITC-labeled erythrocytes,” Microvasc. Res. 49, 33–36 (1995).
[CrossRef] [PubMed]

Krombach, F.

C. M. Moser, T. Mempel, J. Hutter, W. M. Kuebler, F. Krombach, “A novel method for the intravital microscopic analysis of leukocyte transendothelial migration,” J. Vasc. Res. 39, 42–50 (2002).

Kuebler, W. M.

C. M. Moser, T. Mempel, J. Hutter, W. M. Kuebler, F. Krombach, “A novel method for the intravital microscopic analysis of leukocyte transendothelial migration,” J. Vasc. Res. 39, 42–50 (2002).

Kvietys, P. R.

D. N. Granger, P. D. Richardson, P. R. Kvietys, N. A. Mortillaro, “Intestinal blood flow,” Gastroenterology 78, 837–863 (1980).
[PubMed]

Laszlo, K.

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

Lefer, A. M.

R. Scalia, T. Murohara, B. Campbell, A. Kaji, A. M. Lefer, “Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature,” Am. J. Physiol. 272, H2584–H2590 (1997).
[PubMed]

Luo, Q. M.

H. Y. Cheng, D. Zhu, Q. M. Luo, S. Q. Zeng, Z. Wang, S. S. Ul’yanov, “Optical monitoring of the dynamic change of blood perfusion,” Chin. J. Lasers 30, 668–705 (2003) (in Chinese).

H. Y. Cheng, Q. M. Luo, S. Q. Zeng, L. Yao, A. J. Wang, S. S. Ul’yanov, “The application of zero-crossings of laser speckle for real-time monitoring of velocity of lymph flow,” Space Med. Med. Eng. 14, 187–191 (2001) (in Chinese).

H. Y. Cheng, Q. M. Luo, Z. Wang, L. Yao, S. S. Ul’yanov, E. I. Ekateryna, S. Q. Zeng, “Application of laser speckle interferometry for monitoring the dynamics of lymph flow,” in International Workshop on Photonics and Imaging in Biology and Medicine, Q. M. Luo, B. Chance, V. V. Tuchin, eds., Proc. SPIE4536, 130–136 (2001).
[CrossRef]

Manfred, O.

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

Mempel, T.

C. M. Moser, T. Mempel, J. Hutter, W. M. Kuebler, F. Krombach, “A novel method for the intravital microscopic analysis of leukocyte transendothelial migration,” J. Vasc. Res. 39, 42–50 (2002).

Messmer, K.

H. Gebhard, S. P. Zysk, H. J. Refior, W. Plitz, K. Messmer, A. Veihelmann, “A new method to investigate inflammatory responses to wear particles in vivo,” J. Vasc. Res. 39, S1 (2002).

Michael, L.

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

Mithofer, K.

K. Mithofer, J. Schmidt, M. M. Gebhard, H. J. Buhr, C. Herfarth, E. Klar, “Measurement of blood flow in pancreatic exchange capillaries with FITC-labeled erythrocytes,” Microvasc. Res. 49, 33–36 (1995).
[CrossRef] [PubMed]

Mortillaro, N. A.

D. N. Granger, P. D. Richardson, P. R. Kvietys, N. A. Mortillaro, “Intestinal blood flow,” Gastroenterology 78, 837–863 (1980).
[PubMed]

Moser, C. M.

C. M. Moser, T. Mempel, J. Hutter, W. M. Kuebler, F. Krombach, “A novel method for the intravital microscopic analysis of leukocyte transendothelial migration,” J. Vasc. Res. 39, 42–50 (2002).

Moskowitz, A. M.

H. Bolay, U. Reuter, A. K. Dunn, Z. Huang, D. A. Boas, A. M. Moskowitz, “Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model,” Nat. Med. 8, 136–142 (2002).
[CrossRef] [PubMed]

Moskowitz, M. A.

A. K. Dunn, H. Bolay, M. A. Moskowitz, D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21, 195–201 (2001).
[CrossRef] [PubMed]

Murohara, T.

R. Scalia, T. Murohara, B. Campbell, A. Kaji, A. M. Lefer, “Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature,” Am. J. Physiol. 272, H2584–H2590 (1997).
[PubMed]

Nakatsue, T.

K. Yaoeda, M. Shirakashi, S. Funaki, H. Funaki, T. Nakatsue, H. Abe, “Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry,” Am. J. Ophthalmol. 129, 734–739 (2000).
[CrossRef] [PubMed]

Nohira, K.

Nossal, R.

Ohura, T.

Oliver, K.

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

Plitz, W.

H. Gebhard, S. P. Zysk, H. J. Refior, W. Plitz, K. Messmer, A. Veihelmann, “A new method to investigate inflammatory responses to wear particles in vivo,” J. Vasc. Res. 39, S1 (2002).

Refior, H. J.

H. Gebhard, S. P. Zysk, H. J. Refior, W. Plitz, K. Messmer, A. Veihelmann, “A new method to investigate inflammatory responses to wear particles in vivo,” J. Vasc. Res. 39, S1 (2002).

Reuter, U.

H. Bolay, U. Reuter, A. K. Dunn, Z. Huang, D. A. Boas, A. M. Moskowitz, “Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model,” Nat. Med. 8, 136–142 (2002).
[CrossRef] [PubMed]

Richarda, G.

J. D. Briers, G. Richarda, X. W. He, “Capillary blood flow monitoring using laser speckle contrast analysis (LASCA),” J. Biomed. Opt. 4, 164–175 (1999).
[CrossRef] [PubMed]

Richardson, P. D.

D. N. Granger, P. D. Richardson, P. R. Kvietys, N. A. Mortillaro, “Intestinal blood flow,” Gastroenterology 78, 837–863 (1980).
[PubMed]

Ruth, B.

B. Ruth, “Measuring the steady-state value and the dynamics of the skin blood flow using the non-contact laser speckle method,” Med. Eng. Phys. 16, 105–111 (1994).
[CrossRef] [PubMed]

Scalia, R.

R. Scalia, T. Murohara, B. Campbell, A. Kaji, A. M. Lefer, “Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature,” Am. J. Physiol. 272, H2584–H2590 (1997).
[PubMed]

Schmidt, J.

K. Mithofer, J. Schmidt, M. M. Gebhard, H. J. Buhr, C. Herfarth, E. Klar, “Measurement of blood flow in pancreatic exchange capillaries with FITC-labeled erythrocytes,” Microvasc. Res. 49, 33–36 (1995).
[CrossRef] [PubMed]

Shintomi, Y.

Shirakashi, M.

K. Yaoeda, M. Shirakashi, S. Funaki, H. Funaki, T. Nakatsue, H. Abe, “Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry,” Am. J. Ophthalmol. 129, 734–739 (2000).
[CrossRef] [PubMed]

Shunji, T.

S. Atsushi, T. Shunji, H. Keitaro, “Pharmacological evaluation of a new laser blood flowmeter for measuring coronary blood flow, assessed in the canine isolated, blood-perfused ventricular tissue preparation in comparison with an electromagnetic flowmeter,” Jpn. J. Pharmacol. 80, 263–266 (1999).
[CrossRef]

Solov’eva, A. V.

E. I. Galanzha, I. V. Fedosov, A. V. Solov’eva, T. V. Stepanova, V. V. Tuchin, G. E. Brill, “In vivo lymph dynamic monitoring using speckle-correlation technique and light microscopy,” in Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, A. V. Priezzhev, G. L. Cote, eds., Proc. SPIE4624, 130–133 (2002).

Stepanova, T. V.

E. I. Galanzha, I. V. Fedosov, A. V. Solov’eva, T. V. Stepanova, V. V. Tuchin, G. E. Brill, “In vivo lymph dynamic monitoring using speckle-correlation technique and light microscopy,” in Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, A. V. Priezzhev, G. L. Cote, eds., Proc. SPIE4624, 130–133 (2002).

Stern, M. D.

Sucharit, B.

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

Tian, L.

L. Tian, Methodology of Microcirculation (Atomic Energy, Beijing, 1993).

Tibor, K.

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

Tuchin, V. V.

V. V. Tuchin, “Coherent optical techniques for the analysis of tissue structure and dynamics,” J. Biomed. Opt. 4, 106–124 (1999).
[CrossRef] [PubMed]

S. S. Ul’Yanov, D. A. Zimnyakov, V. V. Tuchin, “Fundamentals and applications of dynamic speckles induced by focused laser beam scattering,” Opt. Eng. 33, 3189–3201 (1994).
[CrossRef]

E. I. Galanzha, G. E. Brill, Y. Aizu, S. S. Ulynov, V. V. Tuchin, “Speckle and Doppler methods of blood and lymph flow monitoring,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 881–937.

D. A. Zimnyakov, J. D. Briers, V. V. Tuchin, “Speckle technologies for monitoring and imaging of tissues and tissuelike phantoms,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 987–1036.

E. I. Galanzha, I. V. Fedosov, A. V. Solov’eva, T. V. Stepanova, V. V. Tuchin, G. E. Brill, “In vivo lymph dynamic monitoring using speckle-correlation technique and light microscopy,” in Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, A. V. Priezzhev, G. L. Cote, eds., Proc. SPIE4624, 130–133 (2002).

Ul’yanov, S. S.

H. Y. Cheng, D. Zhu, Q. M. Luo, S. Q. Zeng, Z. Wang, S. S. Ul’yanov, “Optical monitoring of the dynamic change of blood perfusion,” Chin. J. Lasers 30, 668–705 (2003) (in Chinese).

H. Y. Cheng, Q. M. Luo, S. Q. Zeng, L. Yao, A. J. Wang, S. S. Ul’yanov, “The application of zero-crossings of laser speckle for real-time monitoring of velocity of lymph flow,” Space Med. Med. Eng. 14, 187–191 (2001) (in Chinese).

S. S. Ul’Yanov, D. A. Zimnyakov, V. V. Tuchin, “Fundamentals and applications of dynamic speckles induced by focused laser beam scattering,” Opt. Eng. 33, 3189–3201 (1994).
[CrossRef]

H. Y. Cheng, Q. M. Luo, Z. Wang, L. Yao, S. S. Ul’yanov, E. I. Ekateryna, S. Q. Zeng, “Application of laser speckle interferometry for monitoring the dynamics of lymph flow,” in International Workshop on Photonics and Imaging in Biology and Medicine, Q. M. Luo, B. Chance, V. V. Tuchin, eds., Proc. SPIE4536, 130–136 (2001).
[CrossRef]

Ulynov, S. S.

E. I. Galanzha, G. E. Brill, Y. Aizu, S. S. Ulynov, V. V. Tuchin, “Speckle and Doppler methods of blood and lymph flow monitoring,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 881–937.

Veihelmann, A.

H. Gebhard, S. P. Zysk, H. J. Refior, W. Plitz, K. Messmer, A. Veihelmann, “A new method to investigate inflammatory responses to wear particles in vivo,” J. Vasc. Res. 39, S1 (2002).

Wang, A. J.

H. Y. Cheng, Q. M. Luo, S. Q. Zeng, L. Yao, A. J. Wang, S. S. Ul’yanov, “The application of zero-crossings of laser speckle for real-time monitoring of velocity of lymph flow,” Space Med. Med. Eng. 14, 187–191 (2001) (in Chinese).

Wang, Z.

H. Y. Cheng, D. Zhu, Q. M. Luo, S. Q. Zeng, Z. Wang, S. S. Ul’yanov, “Optical monitoring of the dynamic change of blood perfusion,” Chin. J. Lasers 30, 668–705 (2003) (in Chinese).

H. Y. Cheng, Q. M. Luo, Z. Wang, L. Yao, S. S. Ul’yanov, E. I. Ekateryna, S. Q. Zeng, “Application of laser speckle interferometry for monitoring the dynamics of lymph flow,” in International Workshop on Photonics and Imaging in Biology and Medicine, Q. M. Luo, B. Chance, V. V. Tuchin, eds., Proc. SPIE4536, 130–136 (2001).
[CrossRef]

Webster, S.

J. D. Briers, S. Webster, “Laser speckle contrast analysis (LASCA): A nonscanning, full-field technique for monitoring capillary blood flow,” J. Biomed. Opt. 1, 174–179 (1996).
[CrossRef] [PubMed]

Yao, L.

H. Y. Cheng, Q. M. Luo, S. Q. Zeng, L. Yao, A. J. Wang, S. S. Ul’yanov, “The application of zero-crossings of laser speckle for real-time monitoring of velocity of lymph flow,” Space Med. Med. Eng. 14, 187–191 (2001) (in Chinese).

H. Y. Cheng, Q. M. Luo, Z. Wang, L. Yao, S. S. Ul’yanov, E. I. Ekateryna, S. Q. Zeng, “Application of laser speckle interferometry for monitoring the dynamics of lymph flow,” in International Workshop on Photonics and Imaging in Biology and Medicine, Q. M. Luo, B. Chance, V. V. Tuchin, eds., Proc. SPIE4536, 130–136 (2001).
[CrossRef]

Yaoeda, K.

K. Yaoeda, M. Shirakashi, S. Funaki, H. Funaki, T. Nakatsue, H. Abe, “Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry,” Am. J. Ophthalmol. 129, 734–739 (2000).
[CrossRef] [PubMed]

Zeng, S. Q.

H. Y. Cheng, D. Zhu, Q. M. Luo, S. Q. Zeng, Z. Wang, S. S. Ul’yanov, “Optical monitoring of the dynamic change of blood perfusion,” Chin. J. Lasers 30, 668–705 (2003) (in Chinese).

H. Y. Cheng, Q. M. Luo, S. Q. Zeng, L. Yao, A. J. Wang, S. S. Ul’yanov, “The application of zero-crossings of laser speckle for real-time monitoring of velocity of lymph flow,” Space Med. Med. Eng. 14, 187–191 (2001) (in Chinese).

H. Y. Cheng, Q. M. Luo, Z. Wang, L. Yao, S. S. Ul’yanov, E. I. Ekateryna, S. Q. Zeng, “Application of laser speckle interferometry for monitoring the dynamics of lymph flow,” in International Workshop on Photonics and Imaging in Biology and Medicine, Q. M. Luo, B. Chance, V. V. Tuchin, eds., Proc. SPIE4536, 130–136 (2001).
[CrossRef]

Zhu, D.

H. Y. Cheng, D. Zhu, Q. M. Luo, S. Q. Zeng, Z. Wang, S. S. Ul’yanov, “Optical monitoring of the dynamic change of blood perfusion,” Chin. J. Lasers 30, 668–705 (2003) (in Chinese).

Zimnyakov, D. A.

S. S. Ul’Yanov, D. A. Zimnyakov, V. V. Tuchin, “Fundamentals and applications of dynamic speckles induced by focused laser beam scattering,” Opt. Eng. 33, 3189–3201 (1994).
[CrossRef]

D. A. Zimnyakov, J. D. Briers, V. V. Tuchin, “Speckle technologies for monitoring and imaging of tissues and tissuelike phantoms,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 987–1036.

Zysk, S. P.

H. Gebhard, S. P. Zysk, H. J. Refior, W. Plitz, K. Messmer, A. Veihelmann, “A new method to investigate inflammatory responses to wear particles in vivo,” J. Vasc. Res. 39, S1 (2002).

Am. J. Ophthalmol. (1)

K. Yaoeda, M. Shirakashi, S. Funaki, H. Funaki, T. Nakatsue, H. Abe, “Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry,” Am. J. Ophthalmol. 129, 734–739 (2000).
[CrossRef] [PubMed]

Am. J. Physiol. (1)

R. Scalia, T. Murohara, B. Campbell, A. Kaji, A. M. Lefer, “Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature,” Am. J. Physiol. 272, H2584–H2590 (1997).
[PubMed]

Appl. Opt. (2)

Chin. J. Lasers (1)

H. Y. Cheng, D. Zhu, Q. M. Luo, S. Q. Zeng, Z. Wang, S. S. Ul’yanov, “Optical monitoring of the dynamic change of blood perfusion,” Chin. J. Lasers 30, 668–705 (2003) (in Chinese).

Gastroenterology (1)

D. N. Granger, P. D. Richardson, P. R. Kvietys, N. A. Mortillaro, “Intestinal blood flow,” Gastroenterology 78, 837–863 (1980).
[PubMed]

J. Biomed. Opt. (3)

J. D. Briers, G. Richarda, X. W. He, “Capillary blood flow monitoring using laser speckle contrast analysis (LASCA),” J. Biomed. Opt. 4, 164–175 (1999).
[CrossRef] [PubMed]

V. V. Tuchin, “Coherent optical techniques for the analysis of tissue structure and dynamics,” J. Biomed. Opt. 4, 106–124 (1999).
[CrossRef] [PubMed]

J. D. Briers, S. Webster, “Laser speckle contrast analysis (LASCA): A nonscanning, full-field technique for monitoring capillary blood flow,” J. Biomed. Opt. 1, 174–179 (1996).
[CrossRef] [PubMed]

J. Cereb. Blood Flow Metab. (1)

A. K. Dunn, H. Bolay, M. A. Moskowitz, D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21, 195–201 (2001).
[CrossRef] [PubMed]

J. Opt. Soc. Am. (1)

J. D. Briers, “Laser Doppler and time-varying speckle: a reconciliation,” J. Opt. Soc. Am. 13, 345–350 (1996).
[CrossRef]

J. Surg. Res. (1)

H. Georg, K. Tibor, L. Michael, O. Manfred, K. Laszlo, L. Hans-Anton, B. Sucharit, M. Jürgen, K. Oliver, H. Axel, “Plastic foil technique attenuates inflammation in mesenteric intravital microscopy,” J. Surg. Res. 94, 28–34 (2000).
[CrossRef]

J. Vasc. Res. (2)

H. Gebhard, S. P. Zysk, H. J. Refior, W. Plitz, K. Messmer, A. Veihelmann, “A new method to investigate inflammatory responses to wear particles in vivo,” J. Vasc. Res. 39, S1 (2002).

C. M. Moser, T. Mempel, J. Hutter, W. M. Kuebler, F. Krombach, “A novel method for the intravital microscopic analysis of leukocyte transendothelial migration,” J. Vasc. Res. 39, 42–50 (2002).

Jpn. J. Pharmacol. (1)

S. Atsushi, T. Shunji, H. Keitaro, “Pharmacological evaluation of a new laser blood flowmeter for measuring coronary blood flow, assessed in the canine isolated, blood-perfused ventricular tissue preparation in comparison with an electromagnetic flowmeter,” Jpn. J. Pharmacol. 80, 263–266 (1999).
[CrossRef]

Med. Eng. Phys. (1)

B. Ruth, “Measuring the steady-state value and the dynamics of the skin blood flow using the non-contact laser speckle method,” Med. Eng. Phys. 16, 105–111 (1994).
[CrossRef] [PubMed]

Microvasc. Res. (1)

K. Mithofer, J. Schmidt, M. M. Gebhard, H. J. Buhr, C. Herfarth, E. Klar, “Measurement of blood flow in pancreatic exchange capillaries with FITC-labeled erythrocytes,” Microvasc. Res. 49, 33–36 (1995).
[CrossRef] [PubMed]

Nat. Med. (1)

H. Bolay, U. Reuter, A. K. Dunn, Z. Huang, D. A. Boas, A. M. Moskowitz, “Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model,” Nat. Med. 8, 136–142 (2002).
[CrossRef] [PubMed]

NeuroImage (1)

B. M. Ances, J. H. Greenberg, J. A. Detre, “Laser Doppler imaging of activation-flow coupling in the rat somatosensory cortex,” NeuroImage 10, 716–723 (1999).
[CrossRef] [PubMed]

Opt. Commun. (1)

A. F. Fercher, J. D. Briers, “Flow visualization by means of single-exposure speckle photography,” Opt. Commun. 37, 326–329 (1981).
[CrossRef]

Opt. Eng. (1)

S. S. Ul’Yanov, D. A. Zimnyakov, V. V. Tuchin, “Fundamentals and applications of dynamic speckles induced by focused laser beam scattering,” Opt. Eng. 33, 3189–3201 (1994).
[CrossRef]

Opt. Lett. (1)

Proc. IEEE (1)

J. W. Goodman, “Some effects of target-induced scintillation on optical radar performance,” Proc. IEEE 53, 1688–1700 (1965).
[CrossRef]

Space Med. Med. Eng. (1)

H. Y. Cheng, Q. M. Luo, S. Q. Zeng, L. Yao, A. J. Wang, S. S. Ul’yanov, “The application of zero-crossings of laser speckle for real-time monitoring of velocity of lymph flow,” Space Med. Med. Eng. 14, 187–191 (2001) (in Chinese).

Other (6)

H. Y. Cheng, Q. M. Luo, Z. Wang, L. Yao, S. S. Ul’yanov, E. I. Ekateryna, S. Q. Zeng, “Application of laser speckle interferometry for monitoring the dynamics of lymph flow,” in International Workshop on Photonics and Imaging in Biology and Medicine, Q. M. Luo, B. Chance, V. V. Tuchin, eds., Proc. SPIE4536, 130–136 (2001).
[CrossRef]

D. A. Zimnyakov, J. D. Briers, V. V. Tuchin, “Speckle technologies for monitoring and imaging of tissues and tissuelike phantoms,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 987–1036.

S. J. Kirkpatrick, D. D. Duncan, “Optical assessment of tissue mechanics,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 1037–1084.

L. Tian, Methodology of Microcirculation (Atomic Energy, Beijing, 1993).

E. I. Galanzha, G. E. Brill, Y. Aizu, S. S. Ulynov, V. V. Tuchin, “Speckle and Doppler methods of blood and lymph flow monitoring,” in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, ed. (SPIE Press, Bellingham, Wash., 2002), pp. 881–937.

E. I. Galanzha, I. V. Fedosov, A. V. Solov’eva, T. V. Stepanova, V. V. Tuchin, G. E. Brill, “In vivo lymph dynamic monitoring using speckle-correlation technique and light microscopy,” in Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, A. V. Priezzhev, G. L. Cote, eds., Proc. SPIE4624, 130–133 (2002).

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (4)

Fig. 1
Fig. 1

Schematic illustration of setup for speckle imaging. A He-Ne laser (λ = 632.8 nm, 3 mW) beam is expanded to illuminate a 0.8 mm × 1 mm area of the mesentery, which is imaged onto a CCD camera. The computer acquires raw speckle images and computes relative blood-flow maps.

Fig. 2
Fig. 2

Relative velocity (2T c ) shows good correlation (R 2 = 0.98) with the actual velocity. The solid line is a least-squares fit, denoting the linearity relationship when the porcelain surface moves with velocities ranging from 0 to 2 mm/s.

Fig. 3
Fig. 3

Blood-flow images of the mesentery under the influence of noradrenaline. The size of the imaged area is 0.8 mm × 1 mm. (a) Image of the mesentery under white-light illumination. (b)–(f) Measured velocity images obtained by LSI, demonstrating the spatial flow heterogeneities across the imaged area under (b) the control condition and (c)–(f) after the application of noradrenaline, which is represented at the time points shown in Fig. 4. The darker values correspond to lower blood flow. Blood vessels 1 and 2 are a veinule and an arteriole, respectively, in which the relative blood flow (percentage of baseline) is plotted in Fig. 4.

Fig. 4
Fig. 4

Time course of the change of relative blood flow (percentage of baseline) in vessels 1 (dashed curve) and 2 (solid curve). The arrows denote the time points of corresponding images in Figs. 3(b)3(f).

Equations (1)

Equations on this page are rendered with MathJax. Learn more.

k=σsI=τc2T1-exp-2Tτc1/2.

Metrics