Abstract

We present a mathematical model that describes the spatial distribution of photons in fluorescence endoscopic images, resulting in expressions for image signal-to-noise ratio and resolution. This model was applied to quantitative analysis of fluorescence images collected from human colonic mucosa with a fiber-optic and an electronic endoscope. It provides a tool for the design of fluorescence endoscopic imaging systems and for extraction of quantitative information about image features. The results apply generally to endoscopic imaging of remote structures in biological and industrial settings, in which light of weak intensity such as fluorescence as well as reflected white light is used.

© 1998 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Targeted imaging of colorectal dysplasia in living mice with fluorescence microendoscopy

Sakib F. Elahi, Sharon J. Miller, Bishnu Joshi, and Thomas D. Wang
Biomed. Opt. Express 2(4) 981-986 (2011)

Towards clinically translatable NIR fluorescence molecular guidance for colonoscopy

P. Beatriz Garcia-Allende, Jürgen Glatz, Maximilian Koch, Jolien J. Tjalma, Elmire Hartmans, Anton G.T. Terwisscha van Scheltinga, Panagiotis Symvoulidis, Gooitzen M. van Dam, Wouter B. Nagengast, and Vasilis Ntziachristos
Biomed. Opt. Express 5(1) 78-92 (2014)

Gradient index lens based combined two-photon microscopy and optical coherence tomography

Taejun Wang, Qingyun Li, Peng Xiao, Jinhyo Ahn, Young Eun Kim, Youngrong Park, Minjun Kim, Miyeoun Song, Euiheon Chung, Wan Kyun Chung, G-One Ahn, Sungjee Kim, Pilhan Kim, Seung-Jae Myung, and Ki Hean Kim
Opt. Express 22(11) 12962-12970 (2014)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (5)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (2)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (12)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription