Abstract

We examine the impact of background lumiphore on image quality in luminescence optical tomography. A modification of a previously described algorithm [ J. Chang, H. L. Graber, and R. L. Barbour, J. Opt. Soc. Am. A 14, 288–299 (1997); J. Chang, H. L. Graber, and R. L. Barbour, IEEE Trans. Biomed. Eng. 44, 810–822 (1997)] that estimates the background luminescence directly from the detector readings is developed. Numerical simulations were performed to calculate the diffusion-regime limiting form of forward-problem solutions for a specific test medium. We performed image reconstructions with and without white noise added to the detector readings, using both the original and the improved versions of the algorithm. The results indicate that the original version produces unsatisfactory reconstructions when background lumiphore is present, whereas the improved algorithm yields qualitatively better images, especially for small target-to-background luminescence yield ratios.

© 1998 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Luminescence optical tomography of dense scattering media

Jenghwa Chang, Harry L. Graber, and Randall L. Barbour
J. Opt. Soc. Am. A 14(1) 288-299 (1997)

Time resolved fluorescence tomography of turbid media based on lifetime contrast

Anand T. N. Kumar, Scott B. Raymond, Gregory Boverman, David A. Boas, and Brian J. Bacskai
Opt. Express 14(25) 12255-12270 (2006)

Multiplexed fluorescence tomography with spectral and temporal data: demixing with intrinsic regularization

Vivian Pera, Dana H. Brooks, and Mark Niedre
Biomed. Opt. Express 7(1) 111-131 (2016)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (4)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription