Abstract

The detection and identification of nanoparticles is of growing interest in atmospheric monitoring, medicine, and semiconductor manufacturing. While elastic light scattering with interferometric detection provides good sensitivity to single particles, active optical components prevent scalability of realistic sizes for deployment in the field or clinic. Here, we report on a simple phase-sensitive nanoparticle detection scheme with no active optical elements. Two measurements are taken simultaneously, allowing the amplitude and phase to be decoupled. We demonstrate the detection of 25nm Au particles in liquid in Δt1ms with a signal-to-noise ratio of 37. Such performance makes it possible to detect nanoscale contaminants or larger proteins in real time without the need of artificial labeling.

© 2010 Optical Society of America

Full Article  |  PDF Article
More Like This
Tunable sensitivity phase detection of transmitted-type dual-channel guided-mode resonance sensor based on phase-shift interferometry

Wen-Kai Kuo, Siang-He Syu, Peng-Zhi Lin, and Hsin Her Yu
Appl. Opt. 55(4) 903-907 (2016)

Surface-enhanced plasmon resonance detection of nanoparticle-conjugated DNA hybridization

Seyoung Moon, Dong Jun Kim, Kyujung Kim, Donghyun Kim, Hosub Lee, Kangtaek Lee, and Seungjoo Haam
Appl. Opt. 49(3) 484-491 (2010)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (12)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription