Abstract
We propose a new, to the best of our knowledge, technique to capture single particles in real-time in a microfluidic system with controlled flow using micro-pillar traps fabricated by one-step. The micro pillars are fabricated in parallel by femtosecond multi-foci laser beams, which are generated by multiplexing gratings. As the generation process does not need integration loops, the pattern and the intensity distribution of the foci array can be controlled in real-time by changing the parameters of gratings. The real-time control of the foci array enables rapidly fabricating microtraps in the microchannel with adjustment of the pillar spaces and patterns according to the sizes and shapes of target particles. This technology provides an important step towards using platforms based on single-particle analysis, and it paves the way for the development of innovative microfluidic devices for single-cell analysis.
© 2021 Optical Society of America
Full Article | PDF ArticleMore Like This
Bing Xu, Shengyun Ji, Deng Pan, Wenjin Hu, Suwan Zhu, Yanlei Hu, Jiawen Li, Dong Wu, Jiaru Chu, and Koji Sugioka
Opt. Lett. 45(5) 1071-1074 (2020)
Runzhang Xie, Peng Wang, Fang Wang, Xiaoshuang Chen, Wei Lu, and Weida Hu
Opt. Lett. 46(6) 1361-1364 (2021)
Chaowei Wang, Zhijiang Hu, Liang Yang, Chenchu Zhang, Leran Zhang, Shengyun Ji, Liqun Xu, Jiawen Li, Yanlei Hu, Dong Wu, Jiaru Chu, and Koji Sugioka
Opt. Lett. 46(12) 2968-2971 (2021)