Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Spatial-domain low-coherence quantitative phase microscopy for cancer diagnosis

Not Accessible

Your library or personal account may give you access

Abstract

A microscopy technique, spatial-domain low-coherence quantitative phase microscopy (SL-QPM) is proposed for speckle-free, quantitative phase imaging of subcellular structures with subnanometer sensitivity. We quantified, for the first time to our knowledge, the refractive index of the cell nuclei on original unmodified histology specimens. We demonstrate that the refractive index of cell nucleus is highly sensitive in detecting cancer, especially in histologically normal-appearing cells from cancer patients. Because this technique is sensitive and does not require special sample processing, it can be disseminated to all clinical settings.

© 2010 Optical Society of America

Full Article  |  PDF Article
More Like This
Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging

Chulmin Joo, Taner Akkin, Barry Cense, Boris H. Park, and Johannes F. de Boer
Opt. Lett. 30(16) 2131-2133 (2005)

Full-field optical coherence microscopy for identifying live cancer cells by quantitative measurement of refractive index distribution

Woo June Choi, Do In Jeon, Sang-Gun Ahn, Jung-Hoon Yoon, Sungho Kim, and Byeong Ha Lee
Opt. Express 18(22) 23285-23295 (2010)

Low coherence quantitative phase microscopy with machine learning model and Raman spectroscopy for the study of breast cancer cells and their classification

Vishesh Dubey, Azeem Ahmad, Ankit Butola, Darakhshan Qaiser, Anurag Srivastava, and Dalip Singh Mehta
Appl. Opt. 58(5) A112-A119 (2019)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (4)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved