Abstract

Optical tomography of turbid media has so far been limited by systems that require fixed geometries or measurements employing fibers. We present a system that records noncontact optical measurements from diffuse media of arbitrary shapes and retrieves the three-dimensional surface information of the diffuse medium. We further present a novel method of combining this composite data set and obtain accurate fluorescence reconstructions. This approach offers significant experimental simplicity and yields high-information-content datasets. The performance of this novel tomographic approach is demonstrated with experimental reconstructions of phantoms.

© 2003 Optical Society of America

Noncontact fluorescence diffuse optical tomography of heterogeneous media

L. Hervé, A. Koenig, A. Da Silva, M. Berger, J. Boutet, J. M. Dinten, P. Peltié, and P. Rizo
Appl. Opt. 46(22) 4896-4906 (2007)

Fast analytical approximation for arbitrary geometries in diffuse optical tomography

Jorge Ripoll, Manuel Nieto-Vesperinas, Ralph Weissleder, and Vasilis Ntziachristos
Opt. Lett. 27(7) 527-529 (2002)

Fluorescence-lifetime-based tomography for turbid media

Anand T.N. Kumar, Jesse Skoch, Brian J. Bacskai, David A. Boas, and Andrew K. Dunn
Opt. Lett. 30(24) 3347-3349 (2005)

Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation

Vasilis Ntziachristos and Ralph Weissleder
Opt. Lett. 26(12) 893-895 (2001)

Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media

Elizabeth M. C. Hillman, David A. Boas, Anders M. Dale, and Andrew K. Dunn
Opt. Lett. 29(14) 1650-1652 (2004)