Abstract

A tunable diode laser absorption spectroscopy (TDLAS) system equipped with a IV–VI mid-IR laser operating near $5.2 \mathit{\mu }\mathrm{m}$ was used to measure exhaled nitric oxide (eNO) and carbon dioxide $\left({\mathrm{CO}}_2\right)$ simultaneously in human breath over a single exhalation. Breath was sampled in real time, and eNO levels were measured from seven volunteers, two steroid-naive asthmatics and five nonasthmatics. Measured ${\mathrm{CO}}_2$ levels were used as an internal standard to verify correct breath collection and calculate eNO values. Calculated eNO concentrations agreed well with reported values for asthmatic and nonasthmatic individuals.

© 2002 Optical Society of America

Nitric oxide breath testing by tunable-diode laser absorption spectroscopy: application in monitoring respiratory inflammation

Chad Roller, Khosrow Namjou, James D. Jeffers, Mark Camp, Adam Mock, Patrick J. McCann, and Joe Grego
Appl. Opt. 41(28) 6018-6029 (2002)

Measurement of exhaled nitric oxide in beef cattle using tunable diode laser absorption spectroscopy

C. B. Roller, B. P. Holland, G. McMillen, D. L. Step, C. R. Krehbiel, K. Namjou, and P. J. McCann
Appl. Opt. 46(8) 1333-1342 (2007)

Measurement of acetaldehyde in exhaled breath using a laser absorption spectrometer

Pratyuma C. Kamat, Chad B. Roller, Khosrow Namjou, James D. Jeffers, Ali Faramarzalian, Rodolfo Salas, and Patrick J. McCann
Appl. Opt. 46(19) 3969-3975 (2007)

Near-infrared tunable diode laser absorption spectroscopy-based determination of carbon dioxide in human exhaled breath

Cunguang Lou, Congrui Jing, Xin Wang, Yuhao Chen, Jiantao Zhang, Kaixuan Hou, Jianquan Yao, and Xiuling Liu
Biomed. Opt. Express 10(11) 5486-5496 (2019)

Mid-infrared quantum cascade laser based off-axis integrated cavity output spectroscopy for biogenic nitric oxide detection

Yury A. Bakhirkin, Anatoliy A. Kosterev, Chad Roller, Robert F. Curl, and Frank K. Tittel
Appl. Opt. 43(11) 2257-2266 (2004)