Abstract
The analysis of electroretinogram a waves from locally stimulated populations of rods is complicated by the presence of scattered light within the eye. Scattered-light and cone contributions can be assessed after brief flashes of light designed to saturate only rods in the locally stimulated area. Subtracting the scattered-light and the cone responses from the local electroretinogram gives a pure rod a wave that can be fitted with models of photoreceptor activity. We demonstrate the feasibility of this technique by recording local rod a waves from a group of five normal subjects and by fitting the a waves with the rod model to derive transduction parameters. The local rod a waves are compared with expected responses derived from simulations in which the response of the entire retina to heterogeneous illumination is mimicked.
© 1995 Optical Society of America
Full Article | PDF ArticleMore Like This
Yoshinobu Goto, Neal S. Peachey, Nancy E. Ziroli, William H. Seiple, Chester Gryczan, David R. Pepperberg, and Muna I. Naash
J. Opt. Soc. Am. A 13(3) 577-585 (1996)
Donald C. Hood, Sherif Shady, and David G. Birch
J. Opt. Soc. Am. A 10(7) 1624-1630 (1993)
Mary A. Johnson and Donald C. Hood
J. Opt. Soc. Am. A 13(3) 572-576 (1996)