Abstract

Optical methods and MTT method are used to characterize the antiproliferation effect of antitumor drug 9-aminoacridine (9AA) with and without silver nanoparticles. Intracellular surface enhanced Raman scattering (SERS) spectra and fluorescent spectra of 9AA indicate the form of 9AA adsorbed on the surface of silver nanoparticles. Although both silver nanoparticles and antitumor drug can inhibit the growth of Hela cells, silver nanoparticles can slow down the antiproliferation effect on Hela cells at low concentration of antitumor drugs. Our experimental results suggest that silver nanoparticles may serve as slow-release drug carriers, which is important in antitumor drug delivery.

© 2009 Chinese Optics Letters

High-performance surface-enhanced Raman scattering substrate prepared by self-assembling of silver nanoparticles into the nanogaps of silver nanoislands

Jiamin Quan, Yong Zhu, Jie Zhang, Junyin Li, and Ning Wang
Appl. Opt. 56(20) 5751-5760 (2017)

Photoreduced silver nanoparticles grown on femtosecond laser ablated, D-shaped fiber probe for surface-enhanced Raman scattering

Zhen Yin, Youfu Geng, Qingli Xie, Xueming Hong, Xiaoling Tan, Yuzhi Chen, Lele Wang, Wenjia Wang, and Xuejin Li
Appl. Opt. 55(20) 5408-5412 (2016)

Leukemia cells detection based on electroporation assisted surface-enhanced Raman scattering

Yun Yu, Juqiang Lin, Duo Lin, Shangyuan Feng, Weiwei Chen, Zufang Huang, Hao Huang, and Rong Chen
Biomed. Opt. Express 8(9) 4108-4121 (2017)

Method of optical manipulation of gold nanoparticles for surface-enhanced Raman scattering in a microcavity

Kun Xin, Xiaofeng Shi, Yi Liu, Zimeng Zhang, Wenjie Jia, and Jun Ma
Opt. Express 28(6) 8734-8743 (2020)

Plasmonic coupling of silver nanoparticles covered by hydrogen-terminated graphene for surface-enhanced Raman spectroscopy

Chih-Yi Liu, Keng-Chih Liang, Waileong Chen, Chia-hao Tu, Chuan-Pu Liu, and Yonhua Tzeng
Opt. Express 19(18) 17092-17098 (2011)