Abstract

Myotoxin <i>a</i> is a muscle-degenerating toxin isolated from the venom of <i>Crotalus viridis viridis</i> (prairie rattlesnake). It is composed of 42 amino acid residues with four disulfide bonds. The presence of myotoxin <i>a</i> and related myotoxins is common in various snake venoms. It was found recently that myotoxin <i>a</i> is an uncoupler of calcium ion influx in sarcoplasmic reticulum (SR). Myotoxin <i>a</i> is known to interact with artificial membranes. Since the biological action of myotoxin <i>a</i> affects the calcium pump that is present in the SR membranes, it is of interest to investigate the interaction of SR membrane with myotoxin <i>a</i> by Raman spectroscopy. Raman spectroscopy is particularly useful in membrane study because the C-C and C-H stretching vibrational bands are particularly sensitive in phospholipid phase transition from gel to liquid crystal.

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