Reflectance variation of human blood under a magnetic field at the Ar-ion laser line: feasibility for clinical diagnosis

Heihachi Sato; Hidenori Hayashi; Mitsugu Sugiyama; Shuji Tsuchiya

doi:10.1364/AO.20.003360

Applied Optics
Vol. 20,
Issue 19,
pp. 3360-3366
(1981)
•https://doi.org/10.1364/AO.20.003360

Reflectance variation of human blood under a magnetic field at the Ar-ion laser line: feasibility for clinical diagnosis

Heihachi Sato, Hidenori Hayashi, Mitsugu Sugiyama, and Shuji Tsuchiya

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Heihachi Sato, Hidenori Hayashi, Mitsugu Sugiyama, and Shuji Tsuchiya, "Reflectance variation of human blood under a magnetic field at the Ar-ion laser line: feasibility for clinical diagnosis," Appl. Opt. 20, 3360-3366 (1981)

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Abstract

Measuring the reflectance variation ΔR under dc magnetic field at Ar⁺ 0.5017-μm laser line for both corpuscle and plasma human blood samples and applying statistical processing to a 2-D display of ΔR, we can obtain useful information on whether the disease is malignant or benign. Furthermore, for indistinguishable samples within the critical region the correlation between ΔR and conventional blood-analysis parameters gives supplemental information. Applicational feasibility of these experimental results to clinical diagnosis is described together with qualitative considerations of the characteristics obtained.

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		average		covariance	regression line		correl. coeff.

		index	R(%)		slope(10⁻²)	const.
RBC	m	1051.8	−0.740	3.8768	0.044	−1.198	0.070
RBC	b	1064.8	−1.179	2.2480	0.072	−1.949	0.027
Hb	m	32.533	−0.740	0.1321	17.64	−6.480	0.260
Hb	b	32.522	−1.005	0.1257	16.84	−6.482	0.211
WBC	m	17725	−0.757	−288.50	−0.001	−0.682	−0.070
WBC	b	18971	−1.179	476.48	0.001	−1.387	0.049
plat.	m	38.070	−0.740	−0.3949	−0.153	−0.682	−0.042
plat.	b	43.350	−1.179	−2.1534	−1.377	−0.582	−0.116
MCV	m	95.724	−0.740	−0.4964	−0.627	−0.140	−0.095
MCV	b	94.266	−1.005	−0.3943	−1.605	0.508	−0.116
MCH	m	31.155	−0.740	−0.0319	−0.341	−0.634	−0.017
MCH	b	30.681	−0.936	−0.0416	−1.125	−0.591	−0.038

Fe	m	92.357	−0.890	5.7388	0.274	−1.143	0.313
Fe	b	79.300	−1.278	−2.0497	−0.155	−1.155	−0.096
Na	m	135.48	−0.935	−0.3231	−4.147	4.683	−0.236
Na	b	136.61	−1.281	0.0540	0.724	−2.265	0.034
K	m	3.9667	−0.942	−0.0304	−19.58	−0.166	−0.155
K	b	4.0182	−1.281	0.0246	14.11	−1.848	0.102
Cl	m	99.724	−0.970	−0.1488	−1.642	0.668	−0.102
Cl	b	99.818	−1.281	−0.0883	−0.921	−0.362	−0.049
T-pro.	m	6.3727	−0.926	−0.0911	−4.211	−0.657	−0.130
T-pro.	b	6.8606	−1.281	0.0543	10.580	−2.007	0.131
A/G	m	1.2557	−0.927	−0.0217	−30.94	−0.539	−0.168
A/G	b	1.4683	−1.269	−0.0179	−21.58	−0.592	−0.112
Albumin	m	3.6153	−0.909	−0.0855	−20.65	−0.162	−0.278
Albumin	b	4.1070	−1.281	−0.0081	−3.919	−1.120	−0.031
α₁-globu.	m	0.4173	−0.909	0.0028	25.47	−1.015	0.055
α₁-globu.	b	0.4128	−1.278	0.0340	177.60	−2.011	0.418
α₂-globu.	m	0.6403	−0.909	−0.0007	−1.183	−0.901	−0.006
α₂-globu.	b	0.6933	−1.281	0.0232	49.52	−1.624	0.185
β-globu.	m	0.6963	−0.909	−0.0265	−83.04	−0.331	−0.310
β-globu.	b	0.6936	−1.281	−0.0014	−8.791	−1.220	−0.019
γ-globu.	m	1.0879	−0.925	0.0664	21.05	−1.154	0.248
γ-globu.	b	0.9261	−1.281	0.0037	3.082	−1.309	0.018
T-cho.	m	176.17	−0.961	2.3249	0.150	−1.225	0.124
T-cho.	b	166.82	−1.281	0.5289	0.033	−1.335	0.023
Ict. Index	m	6.1667	−0.936	0.5045	5.060	−1.248	0.316
Ict. Index	b	5.0968	−1.264	−0.0256	−0.451	−1.241	−0.018

	malignant	benign

RBC	↑ (+1)	- - - -
Hb	↑↑↑↑↑ (+5)	↑↑↑↑ (+4)
WBC	↓ (−1)	↑ (−1)
plat.	↓ (−1)	↓↓ (−2)
MCV	↓↓ (−2)	↓↓ (−2)
MCH	- - - -	↓ (−1)

Fe	↑↑↑↑↑↑ (+6)	↓↓ (−2)
Na	↓↓↓↓↓ (−5)	↑ (+1)
K	↓↓↓ (−3)	↑↑ (+2)
Cl	↓↓ (−2)	↓ (−1)
T-prot.	↓↓↓ (−3)	↑↑↑ (+3)
A/G	↓↓↓ (−3)	↓↓ (−2)
Albumin	↓↓↓↓↓ (−5)	↓ (−1)
α₁-globulin	↑ (+1)	↑↑↑↑↑↑↑↑ (+8)
α₂-globulin	- - - -	↑↑↑↑ (+4)
β-globulin	↓↓↓↓↓↓ (−6)	- - - -
γ-globulin	↑↑↑↑↑ (+5)	- - - -
T-cho.	↑↑ (+2)	- - - -
Ict. Index	↑↑↑↑↑↑ (+6)	- - - -

		average		covariance	regression line		correl. coeff.

		index	R(%)		slope(10⁻²)	const.
RBC	m	1051.8	−0.740	3.8768	0.044	−1.198	0.070
RBC	b	1064.8	−1.179	2.2480	0.072	−1.949	0.027
Hb	m	32.533	−0.740	0.1321	17.64	−6.480	0.260
Hb	b	32.522	−1.005	0.1257	16.84	−6.482	0.211
WBC	m	17725	−0.757	−288.50	−0.001	−0.682	−0.070
WBC	b	18971	−1.179	476.48	0.001	−1.387	0.049
plat.	m	38.070	−0.740	−0.3949	−0.153	−0.682	−0.042
plat.	b	43.350	−1.179	−2.1534	−1.377	−0.582	−0.116
MCV	m	95.724	−0.740	−0.4964	−0.627	−0.140	−0.095
MCV	b	94.266	−1.005	−0.3943	−1.605	0.508	−0.116
MCH	m	31.155	−0.740	−0.0319	−0.341	−0.634	−0.017
MCH	b	30.681	−0.936	−0.0416	−1.125	−0.591	−0.038

Fe	m	92.357	−0.890	5.7388	0.274	−1.143	0.313
Fe	b	79.300	−1.278	−2.0497	−0.155	−1.155	−0.096
Na	m	135.48	−0.935	−0.3231	−4.147	4.683	−0.236
Na	b	136.61	−1.281	0.0540	0.724	−2.265	0.034
K	m	3.9667	−0.942	−0.0304	−19.58	−0.166	−0.155
K	b	4.0182	−1.281	0.0246	14.11	−1.848	0.102
Cl	m	99.724	−0.970	−0.1488	−1.642	0.668	−0.102
Cl	b	99.818	−1.281	−0.0883	−0.921	−0.362	−0.049
T-pro.	m	6.3727	−0.926	−0.0911	−4.211	−0.657	−0.130
T-pro.	b	6.8606	−1.281	0.0543	10.580	−2.007	0.131
A/G	m	1.2557	−0.927	−0.0217	−30.94	−0.539	−0.168
A/G	b	1.4683	−1.269	−0.0179	−21.58	−0.592	−0.112
Albumin	m	3.6153	−0.909	−0.0855	−20.65	−0.162	−0.278
Albumin	b	4.1070	−1.281	−0.0081	−3.919	−1.120	−0.031
α₁-globu.	m	0.4173	−0.909	0.0028	25.47	−1.015	0.055
α₁-globu.	b	0.4128	−1.278	0.0340	177.60	−2.011	0.418
α₂-globu.	m	0.6403	−0.909	−0.0007	−1.183	−0.901	−0.006
α₂-globu.	b	0.6933	−1.281	0.0232	49.52	−1.624	0.185
β-globu.	m	0.6963	−0.909	−0.0265	−83.04	−0.331	−0.310
β-globu.	b	0.6936	−1.281	−0.0014	−8.791	−1.220	−0.019
γ-globu.	m	1.0879	−0.925	0.0664	21.05	−1.154	0.248
γ-globu.	b	0.9261	−1.281	0.0037	3.082	−1.309	0.018
T-cho.	m	176.17	−0.961	2.3249	0.150	−1.225	0.124
T-cho.	b	166.82	−1.281	0.5289	0.033	−1.335	0.023
Ict. Index	m	6.1667	−0.936	0.5045	5.060	−1.248	0.316
Ict. Index	b	5.0968	−1.264	−0.0256	−0.451	−1.241	−0.018

	malignant	benign

RBC	↑ (+1)	- - - -
Hb	↑↑↑↑↑ (+5)	↑↑↑↑ (+4)
WBC	↓ (−1)	↑ (−1)
plat.	↓ (−1)	↓↓ (−2)
MCV	↓↓ (−2)	↓↓ (−2)
MCH	- - - -	↓ (−1)

Fe	↑↑↑↑↑↑ (+6)	↓↓ (−2)
Na	↓↓↓↓↓ (−5)	↑ (+1)
K	↓↓↓ (−3)	↑↑ (+2)
Cl	↓↓ (−2)	↓ (−1)
T-prot.	↓↓↓ (−3)	↑↑↑ (+3)
A/G	↓↓↓ (−3)	↓↓ (−2)
Albumin	↓↓↓↓↓ (−5)	↓ (−1)
α₁-globulin	↑ (+1)	↑↑↑↑↑↑↑↑ (+8)
α₂-globulin	- - - -	↑↑↑↑ (+4)
β-globulin	↓↓↓↓↓↓ (−6)	- - - -
γ-globulin	↑↑↑↑↑ (+5)	- - - -
T-cho.	↑↑ (+2)	- - - -
Ict. Index	↑↑↑↑↑↑ (+6)	- - - -

Abstract

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Tables (2)

Equations (36)

Applied Optics