Time-Domain Diffuse Correlation Spectroscopy (TD-DCS) is a novel approach that aims at merging Diffuse Correlation Spectroscopy (DCS) with time-domain near-infrared spectroscopy (TD-NIRS) in a single modality [1]. The idea is to excite the tissue with a long-coherence, pulsed laser and acquire the temporal point spread function (TPSF) through the measurement of the photons time-of-flight (ToF). The optical properties of the tissue are recovered by TD-NIRS analysis, while DCS processes the temporal speckle fluctuations due to the moving scatterers in tissue (blood cells) to measure an index of microvascular blood flow (BFi) [2]. Furthermore, the time-domain information allows us discriminate between short and long photon paths to perform NIRS and DCS processing only on photons that have travelled deep into the tissue, increasing the sensitivity to the brain. This discrimination allows us to shorten the source-detector separation, increasing the signal-to-noise ratio, and making the optical sensor more compact.

© 2018 The Author(s)

PDF Article
More Like This
Time-Domain Diffuse Correlation Spectroscopy: from theory to human subject studies

Maria Angela Franceschini, Davide Tamborini, Xiaojun Cheng, Oleg Shatrovoy, Bernhard Zimmermann, Andrew Siegel, Erik Duerr, Stefan Carp, David Boas, and Megan Blackwell
CW2B.1 Clinical and Translational Biophotonics (Translational) 2018

Laser pulse shaping to increase brain blood flow sensitivity of time-domain diffuse correlation spectroscopy

Stefan A. Carp, Adriano Peruch, Davide Tamborini, Dibbyan Mazumder, Melissa M. Wu, Suk-Tak Chan, Mitchell Robinson, Jason Z. Qu, Guillaume Delpont, Thomas Schoenau, Alain Bourdon, and Maria A. Franceschini
JTh2A.36 Clinical and Translational Biophotonics (Translational) 2020

In vivo Time-Domain Diffuse Correlation Spectroscopy with a Superconducting Nanowire Single-Photon Detector

L. Colombo, P. Lanka, A. Brodu, N. Noordzij, M. Pagliazzi, V. Parfentyeva, T. Durduran, and A. Pifferi
ES1B.1 European Conference on Biomedical Optics (ECBO) 2021


You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
Login to access Optica Member Subscription