Ultrasound modulation of light offers potential for overcoming the effects of light scattering in heavily scattering media such as body tissue. With coherent light, a speckle pattern is produced at the detector plane which is modulated when ultrasound is applied. This can be used to extract light which has passed through the ultrasound column. Pulsed ultrasound can be used to allow time gated detection of the ultrasound modulated signal along the ultrasound column. The process of demodulating the speckle pattern using parallel speckle and digital holography is described. This demodulation is also applicable to detection of non-linear ultrasound modulated signal through a pulse inversion technique. Although more challenging in terms of signal detection, extending the ultrasound modulation approach to fluorescence and bioluminescence sensing is also discussed.

© 2013 Optical Society of America

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