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Optica Publishing Group
  • Quantum Electronics and Laser Science Conference
  • OSA Technical Digest (Optica Publishing Group, 1993),
  • paper QTuK45

Laser mass spectrometry for biopolymer analysis

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Abstract

During the past decade tremendous effort has been expended on applying mass spectrometry to biopolymer measurements for biological and medical applications. However, there are two major difficulties: developing a reliable method to deliver these nonvolatile biopolymers and achieving ion production without significant fragmentation in either desorption or ionization steps. Recently it was found that large biopolymers could be put into the gas phase and ionized by a laser in the presence of a large excess of small organic molecules serving as a matrix. This method is in general referred to as matrix-assisted laser desorption. Up to now, matrix-assisted laser desorption has been primarily applied to polypeptides and proteins, but little success has been obtained for oligomers. We applied matrix-assisted laser desorption to both protein and oligomers by choosing adequate matrix materials for different kinds of biopolymers.

© 1993 Optical Society of America

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