3D OCT characterization and quantification of refractive indices of bacteria and biofilms with antibiotic interventions

Farzana R. Zaki; Kavya Sudhir; Jungeun Won; Jungeun Won; Guillermo L. Monroy; Honggu Choi; Eric J. Chaney; Darold R. Spillman; Stephen A. Boppart; Stephen A. Boppart; Stephen A. Boppart; Stephen A. Boppart

doi:10.1364/OMP.2021.OTu3D.5

Biophotonics Congress 2021
OSA Technical Digest (Optica Publishing Group, 2021),
paper OTu3D.5
•https://doi.org/10.1364/OMP.2021.OTu3D.5

3D OCT characterization and quantification of refractive indices of bacteria and biofilms with antibiotic interventions

Farzana R. Zaki, Kavya Sudhir, Jungeun Won, Guillermo L. Monroy, Honggu Choi, Eric J. Chaney, Darold R. Spillman, and Stephen A. Boppart

Optical Molecular Probes, Imaging and Drug Delivery 2021

Washington, DC United States
12–16 April 2021
ISBN: 978-1-943580-85-9

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Theranostics and PDT (OTu3D)

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F. R. Zaki, K. Sudhir, J. Won, G. L. Monroy, H. Choi, E. J. Chaney, D. R. Spillman, and S. A. Boppart, "3D OCT characterization and quantification of refractive indices of bacteria and biofilms with antibiotic interventions," in Biophotonics Congress 2021, C. Boudoux, K. Maitland, C. Hendon, M. Wojtkowski, K. Quinn, M. Schanne-Klein, N. Durr, D. Elson, F. Cichos, L. Oddershede, V. Emiliani, O. Maragò, S. Nic Chormaic, N. Pégard, S. Gibbs, S. Vinogradov, M. Niedre, K. Samkoe, A. Devor, D. Peterka, P. Blinder, and E. Buckley, eds., OSA Technical Digest (Optica Publishing Group, 2021), paper OTu3D.5.

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Abstract

Using 3D OCT, we have quantified the refractive indices of ear-infection causing bacteria and biofilms with antibiotics interventions. This approach reveals changing optical properties of bacteria in biofilms following the delivery of antibiotics.

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