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Conferences > OMP > 2021 > OTh2D > OTh2D.4

Combining PARPi-FL fluorescence and reflectance contrast for improved detection of basal cell carcinoma (BCC)

Aditi Sahu, Jose Cordero, Xiancheng Wu, Paula Demetrio Desouza Franca, Susanne Kossatz, Ucalene Harris, Nicholas Kurtansky, Niasia Everett, Steve Dusza, Jilliana Monnier, Piyush Kumar, Christi Fox, Christian Brand, Sheryl Roberts, Kivanc Kose, William Phillips, Erica Lee, Chih-Shan Jason Chen, Anthony Rossi, Kishwer Nehal, Melissa Pulitzer, Caterina Longo, Allan Halpern, Thomas Reiner, Milind Rajadhyaksha, and Manu Jain

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    A. Sahu, J. Cordero, X. Wu, P. D. D. Franca, S. Kossatz, U. Harris, N. Kurtansky, N. Everett, S. Dusza, J. Monnier, P. Kumar, C. Fox, C. Brand, S. Roberts, K. Kose, W. Phillips, E. Lee, C. J. Chen, A. Rossi, K. Nehal, M. Pulitzer, C. Longo, A. Halpern, T. Reiner, M. Rajadhyaksha, and M. Jain, "Combining PARPi-FL fluorescence and reflectance contrast for improved detection of basal cell carcinoma (BCC)," in Biophotonics Congress 2021, C. Boudoux, K. Maitland, C. Hendon, M. Wojtkowski, K. Quinn, M. Schanne-Klein, N. Durr, D. Elson, F. Cichos, L. Oddershede, V. Emiliani, O. Maragò, S. Nic Chormaic, N. Pégard, S. Gibbs, S. Vinogradov, M. Niedre, K. Samkoe, A. Devor, D. Peterka, P. Blinder, and E. Buckley, eds., OSA Technical Digest (Optica Publishing Group, 2021), paper OTh2D.4.
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Abstract

Towards improving non-invasive BCC diagnosis, we demonstrate successful PARPi-FL (PARP1-targeted nuclear contrast) labeling in tumors, permeability through stratum corneum, and high diagnostic accuracy with combined PARPi-FL and reflectance contrast.

© 2021 The Author(s)

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