Wavefront shaping empowered high-resolution optical focusing at depths in tissue and its application for single neuron optogenetics

Tianting ZHONG; Tianting ZHONG; Zhihai QIU; Zhihai QIU; Shengfu CHENG; Shengfu CHENG; Lei SUN; Lei SUN; Puxiang LAI; Puxiang LAI

doi:10.1364/OECC.2021.W3E.3

26th Optoelectronics and Communications Conference
OSA Technical Digest (Optica Publishing Group, 2021),
paper W3E.3
•https://doi.org/10.1364/OECC.2021.W3E.3

Wavefront shaping empowered high-resolution optical focusing at depths in tissue and its application for single neuron optogenetics

Tianting ZHONG, Zhihai QIU, Shengfu CHENG, Lei SUN, and Puxiang LAI

Optoelectronics and Communications Conference 2021

Hong Kong China
3–7 July 2021
ISBN: 978-1-943580-92-7

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Biophotonics and Tomography (W3E)

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T. ZHONG, Z. QIU, S. CHENG, L. SUN, and P. LAI, "Wavefront shaping empowered high-resolution optical focusing at depths in tissue and its application for single neuron optogenetics," in 26th Optoelectronics and Communications Conference, P. Alexander Wai, H. Tam, and C. Yu, eds., OSA Technical Digest (Optica Publishing Group, 2021), paper W3E.3.

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Abstract

Wide field single neuron activation on primary neurons was achieved by wavefront shaping-enabled multimode fiber-based optogenetics. The capability through intact skull layer opens a new horizon for noninvasive single neuron optogenetics at depths.

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