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Analysis of Fe2+ and Fe3+ formation of hemoglobin closely related with sickle cell disease in fluorescent enhancement of optofluidic resonator

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Abstract

Analysis of Fe2+ and Fe3+formation of hemoglobin closely relate with sickle cell disease in fluorescent enhancement of optofluidic resonator hollow-core cladding-metal waveguide, due to the fluorescence own to high-sensitivity in detection bio-molecule. And the weakly fluorescence intensity can be enhanced more than 45 times in optofluidic resonator. Achieved the anoxia has been closed relationship with the form of heme iron ion. Heme is composed of Fe2+ and Protoporphyrin, and it can catch and carry O-atoms. So the Fe2+ compound can combination with normal hemoglobin. Heme is composed of Fe3+ and protoporphyrin and it lost catch and carry O-atoms functionality. So the study will vital for the treatment of SCD.

© 2017 Optical Society of America

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