Abstract

Photomultiplier tubes are the standard for high sensitivity detection of fluorescence signals, but are costly, fragile, have limited QE and worse sensitivity at far-red wavelengths. Silicon photomultipliers (SIPMs) combine the higher shot-noise limited sensitivity of silicon sensors with the single photon sensitivity of PMTs and can provide higher SNR over a range of common confocal and multiphoton applications. We show how to design low cost electronics that enable extremely high sensitivity, dynamic range, and bandwidth and discuss how to customize high sensitivity detectors for high speed fluorescent imaging.

© 2020 The Author(s)

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