One big breakthrough in laser processing was the invention of a Ti: sapphire femtosecond laser amplifier based on chirped pulse amplification. Its inventors, Gérard Mourou and Donna Strickland, were awarded the 2018 Nobel Prize in Physics for this and their other groundbreaking inventions in the field of laser physics. The prize recognized especially the wide applications that have been made to cell and tissue manipulations. Nowadays, the femtosecond laser amplifier is one of key tool in ophthalmology, biology, and basic medicine. We have developed several kinds of cell manipulation methodologies utilizing the femtosecond laser amplifier and optical microscope. Especially, we noticed mechanical phenomena occurring with the intense pulse irradiation. The intense pulse from the femtosecond laser amplifier generates a shockwave and stress waves efficiently. Furthermore, stress wave propagation that results in these generations induces an explosive evaporation of the aqueous medium, which is called cavitation bubble generation.
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