Abstract
Chiral molecules have different efficiencies in generating second-harmonic generation signal for left- and right-circular-polarized light. This effect is called second-harmonic generation circular dichroism (SHG-CD). It has been shown that SHG-CD exhibits much better chiral contrast than traditional chiroptical spectroscopies [1]. Furthermore, combined with a laser scanning microscope, SHG-CD provides optical sectioning capability that is suitable for examining thick tissue samples. We have shown that type I collagen gives rise to strong second-harmonic generation circular dichroism (SHG-CD) responses [2]. However, to resolve the molecular structures and chiral properties of biological tissues, it is not enough to study SHG-CD for only one specific wavelength.
© 2014 Japan Society of Applied Physics, Optical Society of America
PDF ArticleMore Like This
M.C. Schanne-Klein, T. Boulesteix, F. Hache, M. Alexandre, G. Lemercier, and C. Andraud
ThC2 Nonlinear Optics: Materials, Fundamentals and Applications (NLO) 2002
I. A. Kolmychek, E. A. Mamonov, N. V. Mitetelo, A. A. Ezhov, O. Y. Rogov, V. V. Artemov, M. V. Gorkunov, and T. V. Murzina
JTu4A.77 Frontiers in Optics (FiO) 2019
Rebecca M. Williams, Warren R. Zipfel, and Watt W. Webb
ThEE1 Frontiers in Optics (FiO) 2003