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Interfacial imaging between cell and substrate by localized surface plasmon microscopy toward live observation of cell adhesion sites

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Abstract

Cell adhesion sites, which play essential roles in activating cellular functions, such as signal communication, embryonic morphogenesis, and cell proliferation [1] have been intensively studied through microscopic observations. Although fluorescence microscopy is useful for these imaging, fluorescent labeling potentially affects behaviors of cells. Therefore, development of a method to image the adhesion sites without labeling is important.

© 2013 Japan Society of Applied Physics, Optical Society of America

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