Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Mobile Phone-based Platelet Function Analysis by Speckle Size Measurement

Not Accessible

Your library or personal account may give you access

Abstract

Bleeding disorder related to platelet number and functionality is a key issue before conducting surgery and monitoring the patient’s condition; therefore, reduction in the platelet number or disorder in their function cause bleeding risk. In this study, we introduce an optical evaluation method of platelet aggregation within a channel in a microfluidic chip by measuring the laser speckle size, which is related to the retarded blood flow in the microfluidic channel. With a whole blood sample, the speckle size was 28.54 ± 0.72 µm, and this is due to the aggregation of platelets. On the other hand, after removing the platelets from the blood, we found that the speckle size was significantly reduced to 27.04 ± 1.23 um. Also, by adding agonist containing ADP that can activate the platelets, the difference in speckle size was further increased to 32.89 ± 1.69 um. These findings may provide a simple optical technique with microfluidics to test the function of platelets in the diagnosis of bleeding disorders and may help monitor anti-platelet therapies.

© 2020 The Author(s)

PDF Article
More Like This
Coherent optical scattering and interferometry microscopy for functional imaging of thrombus

Yujie Zheng, Yean Jin Lim, Samantha J. Montague, Elizabeth E. Gardiner, and Woei Ming Lee
MTh3A.3 Microscopy Histopathology and Analytics (Microscopy) 2020

Fine Analysis of Spread Platelets from Healthy and Pathological Human Blood Samples through Automatic Measurement in Digital Holographic Microscopy

Jérôme Dohet-Eraly, Karim Zouaoui Boudjeltia, Alexandre Rousseau, Jean-Marc Desmet, Catherine Yourassowsky, and Frank Dubois
M2A.3 Digital Holography and Three-Dimensional Imaging (DH) 2022

Quantitative Imaging of Platelet Aggregation in a Microchannel Using an Interfacial Collision Reactor

Taisuke Hirono, Shinpei Okawa, and Yukio Yamada
BTuF31 Biomedical Optics (BIOMED) 2008

Poster Presentation

Media 1: PDF (3409 KB)     
Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved