Achieving an adequate signal to background ratio is of paramount importance for targeted diagnostics. Time- or spatially-modulated light would provide improved imaging of exogenous contrast agents through lifetime, depth resolved and quantum yield imaging, and would also permit measurement of endogenous contrast. However, the use of quantitative optical imaging methods is currently plagued by motion artifacts and surface height variations. We investigated surface height variation compensation, motion-gated acquisition, time- and spatially-modulated illumination in the context of large field-of-view image-guided surgery. Our results suggest that the combination of these techniques lay the foundation for translating quantitative optical imaging methods to human surgery.

© 2008 Optical Society of America

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