Abstract

We use femtosecond-laser ablation to lesion cortical microvessels in transgenic mouse models of Alzheimer’s Disease. Aβ plaques and blood flow were imaged in vivo with 2-photon microscopy. Aβ accumulated after lesions which stalled blood flow.

© 2008 Optical Society of America

PDF Article
More Like This
Two-Photon Imaging Reveals Capillary Occlusions are Responsible for Reduced Brain Blood Flow and Cognitive Decline in Alzheimer’s Disease Mouse Models

Jean C. Cruz Hernández, Oliver Bracko, Calvin Kersbergen, Victorine Muse, Mohammad Haft-Javaherian, Iryna Ivasyk, Laibaik Park, Lindsay Vinarcsik, Yiming Kang, Joan Zhou, Jeffrey D. Beverly, Elizabeth Slack, Gabriel Otte, Thom P. Santisakultarm, Costantino Iadecola, Nozomi Nishimura, and Chris B. Schaffer
BrW3B.3 Optics and the Brain (BRAIN) 2017

Volumetric fluorescence imaging combined with modifled optical clearing for Alzheimer’s disease pathology

Lina Liu, Ang Liu, Wen Xiao, Renjian Li, Xuejuan Hu, and Lingling Chen
M2H.3 Asia Communications and Photonics Conference (ACPC) 2018

Investigating Pathological Features of Alzheimer’s Disease in Human and Mouse Brain Tissue with Visible Light Optical Coherence Microscopy

Antonia Lichtenegger, Martina Muck, Pablo Eugui, Danielle J. Harper, Marco Augustin, Christoph K. Hitzenberger, Adelheid Woehrer, and Bernhard Baumann
BF4C.3 Optics and the Brain (BRAIN) 2018

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription