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Quantification of circulating cells using an in vivo flow cytometer

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Abstract

Flow cytometery has been used extensively for the characterization and quantification of circulating cells in animals and humans. The development of sophisticated fluorescent labels has allowed detection of cells with very specific attributes in a highly sensitive manner. In conventional flow cytometry, cell samples are extracted and analyzed outside the body. We have developed a flow cytometer for the detection of circulating fluorescently labeled cells in vivo, without the need to extract a blood sample from the study subject. The technique allows for continuous monitoring of the circulating cell population of interest and, thus, for detection of a very small number of cells, and it yields quantitative results without affecting the physiology of the subject. It could be used for the in vivo detection and quantitative monitoring of red and white blood cells during disease development and processes such as tissue and organ transplantation or of other circulating cells, such as cancer cells in the process of metastasis.

© 2003 Optical Society of America

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