Abstract

Acquisition of molecular information is useful in various aspects of science, industry and medicine. Fluorescence imaging is the most widely used molecular imaging technique in biological fields, but is accompanied by chemical alteration of and photodamage to the sample due to the use of fluorescent labelling agents. Alternatively, label-free molecular-vibrational imaging methods, such as mid-infrared (MIR) absorption imaging and spontaneous/coherent Raman scattering (RS) imaging [1], suffer from low spatial resolution, low sensitivity (low imaging speed), high photodamage and/or the need of custom-made complicated optical systems.

© 2019 IEEE