Abstract

Luminescence diffuse optical tomography has become a valuable tool in optical molecular imaging. As an actor of this recent field, the French company Quidd has developed a luminescence reflectance imaging system for small animal in vivo imaging. In previous studies, we have determined the potential and the limits of such approaches for the determination of the depth of fluorophores/bioluminescent substrates in tissues [1,2]. In the present work, we demonstrate the first reconstructions on test samples. For this study, we use a prototype of the Quidd Optical System (QOS) as well as calibrated phantom (cf. Fig. 1) and source. The optical detection set-up is composed of a cooled CCD camera with a telecentric lens. The camera can be translated along the z and x axes and rotated with an angular amplitude of 120°.

© 2011 IEEE