Abstract

Cancer is one of the leading causes for morbidity and mortality worldwide. Therefore, efforts are concentrated on cancer detection in an early stage to enhance survival rates for cancer patients. A certain intraoperative navigation in the tumor border zone is also an essential task to lower the mortality rate after surgical treatment. Molecular spectroscopy methods proved to be powerful tools to differentiate cancerous and healthy tissue. Within our project comparison of different vibration spectroscopy methods were tested to select the better one or to reach synergy from their combination.

One key aspect was in special fiber probe development for each technique. Using fiber optic probes in Raman, MIR and NIR spectroscopy is a very powerful method for non-invasive in vivo applications. Miniaturization of Raman probes was achieved by deposition of dielectric filters directly onto the silica fiber end surfaces. Raman, NIR and MIR spectroscopy were used to analyze samples from kidney tumors. The differentiation between cancer and healthy samples was successfully obtained by multivariate data analysis.

© 2015 SPIE

PDF Article
More Like This
Fiber spectroscopy for tumor margin detection – selection of the best methods

V. Artyushenko, U. Zabarylo, A. Bogomolov, O. Minet, H. Krause, T. Sakharova, I. Usenov, F. Schulte, and H.J. Eichler
JTu3A.11 Cancer Imaging and Therapy (Cancer) 2016

Tissue classification and diagnostics using a fiber probe for combined Raman and fluorescence spectroscopy

Riccardo Cicchi, Suresh Anand, Alfonso Crisci, Flavio Giordano, Susanna Rossari, Vincenzo De Giorgi, Vincenza Maio, Daniela Massi, Gabriella Nesi, Anna Maria Buccoliero, Renzo Guerrini, Nicola Pimpinelli, and Francesco Saverio Pavone
95370I European Conference on Biomedical Optics (ECBO) 2015

In Vivo Diagnostics of Malignant and Benign Tumors with Low-Cost Raman Spectrometer

Yulia A. Khristoforova, Ivan A. Bratchenko, Dmitry N. Artemyev, Oleg O. Myakinin, Alexandr A. Moryatov, Oleg I. Kaganov, Sergey V. Kozlov, and Valery P. Zakharov
FTu5C.4 Frontiers in Optics (FiO) 2017

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription