Compact imaging system with single-photon sensitivity and picosecond time resolution for fluorescence-guided surgery with lifetime imaging capability

F. Powolny; C. Bruschini; C. Bruschini; E. Dubikovskaya; E. Grigoriev; O. Michielin; K. Muehlethaler; J. O. Prior; D. Rimoldi; R. Sinisi; E. Charbon; E. Charbon

Clinical and Biomedical Spectroscopy and Imaging III
SPIE Proceedings (Optica Publishing Group, 2013),
paper 879806

Compact imaging system with single-photon sensitivity and picosecond time resolution for fluorescence-guided surgery with lifetime imaging capability

F. Powolny, C. Bruschini, E. Dubikovskaya, E. Grigoriev, O. Michielin, K. Muehlethaler, J. O. Prior, D. Rimoldi, R. Sinisi, and E. Charbon

European Conference on Biomedical Optics 2013

Munich Germany
12–16 May 2013
ISBN: 9780819496478

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Clinical and Preclinical Diagnostics III (CPDIII)

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F. Powolny, C. Bruschini, E. Dubikovskaya, E. Grigoriev, O. Michielin, K. Muehlethaler, J. O. Prior, D. Rimoldi, R. Sinisi, and E. Charbon, "Compact imaging system with single-photon sensitivity and picosecond time resolution for fluorescence-guided surgery with lifetime imaging capability," in Clinical and Biomedical Spectroscopy and Imaging III, V. Deckert and N. Ramanujam, eds., Vol. 8798 of SPIE Proceedings (Optica Publishing Group, 2013), paper 879806.

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Abstract

We present a single-photon camera for fluorescence imaging capable of providing both intensity and images, with an accuracy better than 100ps; the camera was fabricated in standard CMOS technology. As a first step towards the study of biologically relevant samples, it was used to characterize in-vitro cultured melanoma cells labeled with indocyanine green (ICG) and ICG conjugated with cyclic pentapeptide (RGDfK). The application field would be fluorescence-guided surgical oncology.

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