Abstract

Photosensitizer fluorescence photobleaching and Singlet Oxygen (1O2) Luminescence Dosimetry (SOLD) are being studied as potential dosimetric tools for ALA-PDT of skin diseases. However, the correlation of both SOLD data and PpIX fluorescence to 1O2 distribution is difficult to interpret because of the temporal and spatial variations of the PDT parameters (light fluence rate, photosensitizer concentration and oxygen concentration). This work used our dynamic model to investigate both dosimetry approaches for varied PpIX concentration and distribution, and three commonly used treatment wavelengths. The results show that SOLD is much less dependent upon the treatment parameters, which implies it has better potential as a “gold standard” dosimetric tool for clinical PDT.

© 2011 OSA/SPIE

PDF Article
More Like This
Online-monitoring of light dosimetry and PpIX fluorescence during PDT with oral ALA in the normal rat esophagus

Hugo J. van Staveren, Jolanda van den Boogert, Ron W.F. de Bruin, Richard van Hillegersberg, and Peter D. Siersema
JMA7 Biomedical Topical Meeting (BIO) 1999

Photochemical model of Photodynamic Therapy applied to skin diseases by a topical photosensitizer

F. Fanjul-Vélez, I. Salas-García, L. A. Fernández-Fernández, M. López-Escobar, L. Buelta-Carrillo, N. Ortega-Quijano, and J. L. Arce-Diego
7373_0S European Conference on Biomedical Optics (ECBO) 2009

Fluorescence Dynamics of ALA-induced PpIX in Normal and Malignant Skin Cells

Caroline D Sudworth, Mark R Stringer, Janet E Cruse-Sawyer, and Stanley B Brown
5142_18 European Conference on Biomedical Optics (ECBO) 2003

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription