Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Spectral unmixing using component analysis in multispectral optoacoustic tomography

Not Accessible

Your library or personal account may give you access

Abstract

Multispectral optoacoustic (photoacoustic) tomography (MSOT) exploits high resolutions given by ultrasound detection technology combined with deeply penetrating laser illumination in the near infrared. Traces of molecules with different spectral absorption profiles, such as blood (oxy- and de-oxygenated) and biomarkers can be recovered using multiple wavelengths excitation and a set of methods described in this work. Three unmixing methods are examined for their performance in decomposing images into components in order to locate fluorescent contrast agents in deep tissue in mice. Following earlier works we find Independent Component Analysis (ICA), which relies on the strong criterion of statistical independence of components, as the most promising approach, being able to clearly identify concentrations that other approaches fail to see. The results are verified by cryosectioning and fluorescence imaging.

© 2011 OSA/SPIE

PDF Article
More Like This
Spectral unmixing using component analysis in multispectral optoacoustic tomography

Stefan Morscher, Jürgen Glatz, Nikolaos C. Deliolanis, Andreas Buehler, Athanasios Sarantopoulos, Daniel Razansky, and Vasilis Ntziachristos
80890 European Conference on Biomedical Optics (ECBO) 2011

Optical attenuation correction in multispectral optoacoustic tomography with logarithm unmixing

X Lúıs Deán-Ben, Andreas Buehler, Vasilis Ntziachristos, and Daniel Razansky
88000H European Conference on Biomedical Optics (ECBO) 2013

Light fluence estimation by imaging photoswitchable probes with temporally unmixed multispectral optoacoustic tomography

X. Luís Deán-Ben, André C. Stiel, Yuanyuan Jiang, Vasilis Ntziachristos, Gil G. Westmeyer, and Daniel Razansky
OTu2A.6 Optical Tomography and Spectroscopy (OT&S) 2016

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved